Nikki Forrester
Nikki Forrester
Structures and Molecular Mechanisms of Insect Odorant and Gustatory Receptors [0.03%]
昆虫嗅觉和味觉受体的结构与分子机制
Xiangnan Zhang,Demin Ma,Jiangqin Wang et al.
Xiangnan Zhang et al.
Insects rely on chemoreceptors in sensory neurons to detect and discriminate various chemicals in constantly changing environments. Among the chemoreceptors, odorant receptors (ORs) and gustatory receptors (GRs) play essential roles in sens...
Growth hormone and IGF-1 actions in the brain and neuropsychiatric diseases [0.03%]
生长激素和IGF-1在大脑及神经精神疾病中的作用
Manuel H Aguiar-Oliveira,Margaret C S Boguszewski,Diego Luiz Rovaris et al.
Manuel H Aguiar-Oliveira et al.
Growth hormone (GH) is secreted by the anterior pituitary gland under the control of hypothalamic neuroendocrine neurons that express somatostatin or growth hormone-releasing hormone (GHRH). Ghrelin, originating primarily in the stomach, is...
Daniel Gagnon,Zachary J Schlader,Ollie Jay
Daniel Gagnon
A direct consequence of climate change is the intensification of hot weather and extreme heat events that are epidemiologically associated with a greater risk of heat-related illnesses and other adverse health outcomes, often resulting in s...
From cells to selves and back: human neurodiversity at single cell resolution [0.03%]
从细胞到自我再到细胞：单细胞分辨率下的人类神经多样性
Manuel Lessi,Nicolò Caporale,Giuseppe Testa
Manuel Lessi
Human brain development is characterized by a complex cellular and molecular landscape, which vary both within and between individuals. Here we explore the transformative impact of single-cell omics technologies on our understanding of huma...
Nikki Forrester
Nikki Forrester
The immunopathophysiology of organ fibrosis: From mechanisms to immunotherapies [0.03%]
器官纤维化的免疫病理生理学：从机制到免疫疗法
Jingyi He,Irina Ferapontova,Jing Chen et al.
Jingyi He et al.
Fibrosis is the ultimate outcome of various chronic diseases that affect multiple organs, including the liver, lungs, heart, and kidneys. This pathological process is characterized by the excessive accumulation of extracellular matrix produ...
Molecular and Inflammatory Etiologies of ß Cell Dysfunction in Type 1 Diabetes [0.03%]
1型糖尿病的β细胞功能障碍的分子和炎症病因学
Cameron R Rostron,Carmella Evans-Molina
Cameron R Rostron
Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune-mediated destruction of pancreatic β cells; however, recent findings indicate that intrinsic stress pathways within β cells may contribute to the initiation or perpetua...
The nose knows: Olfaction as a metabolic gatekeeper in health and disease [0.03%]
识鼻为知：嗅觉在健康和疾病中的代谢守门人作用
Diogo Manoel,Eman Abou Moussa,Asma Al-Naama et al.
Diogo Manoel et al.
Long regarded as an accessory sense, olfaction is now emerging as a metabolic architect-an active agent in energy homeostasis, appetite regulation, and systemic physiology. This review explores the converging lines of evidence positioning t...
Rich Gang Li,Fansen Meng,James F Martin
Rich Gang Li
Ischemic heart disease, which affects more than 200 million people worldwide, is caused by reduced blood flow to the heart and leads to widespread cardiomyocyte death. Due to the limited regenerative potential of cardiomyocytes, the lost ti...