Copper in Human Health and Disease: Insights from Inherited Disorders [0.03%]
铜在人类健康和疾病中的作用：来自遗传疾病的启示
Raffaella Petruzzelli,Elena Polishchuk,Roman Polishchuk
Raffaella Petruzzelli
In recent years, our understanding of copper metabolism in humans has advanced considerably, driven in large part by insights from genetic disorders. Studies of Menkes disease, Wilson disease, MEDNIK and KIDAR syndromes, and most recently C...
Yang Zhang,Xinyue Chi,Qiulian Zhou et al.
Yang Zhang et al.
As populations age worldwide, understanding the biology of aging and its contribution to disease becomes increasingly important. Cellular senescence, a hallmark of aging, plays a pivotal role in shaping inter-organ communication and systemi...
Arjuman Ghazi,Hannah Henry
Arjuman Ghazi
Female reproductive aging is the earliest manifestation of aging in humans, with fertility declining due to reduced oocyte quality well before menopause. Menopause marks the definitive end of reproductive potential and the onset of increase...
Benjamin Wetherall,Suzanne Madgwick
Benjamin Wetherall
Oocyte meiosis, the process of egg cell formation, requires a highly regulated cell cycle with many unique features compared to somatic cell division. On the journey to create a healthy embryo, this special cell carries a heavy responsibili...
A William Sheel,Sarah A Angus
A William Sheel
Under conditions of exercise the heart and lungs are linked in important ways. First, both the heart and lungs are linked in series as pumps for O2 and CO2 transport. Second they are mechanically linked owing to their location within the th...
Zinc Transporters in diseases, including diabetes and related conditions [0.03%]
锌转运蛋白与疾病（包括糖尿病及其相关状况）的关系
Wenjun Xu,Xuan Wang,Yukun Gao et al.
Wenjun Xu et al.
Zinc is an essential trace element that participates in a wide range of physiological processes. Cellular zinc homeostasis is tightly controlled by two families of transporters: the Zrt/Irt-like protein (ZIP/SLC39) family, which mediates zi...
Cocaine-Induced Cardiovascular and Immune Dysfunction: Emerging Mechanisms [0.03%]
可卡因诱导的心血管和免疫功能障碍：新兴机制
Kyce Darouiche,Shelby Devin,Silvana Valdebenito et al.
Kyce Darouiche et al.
Substance use and its associated comorbidities are a global public health crisis affecting millions of people, involving both legal and illicit substances, including cocaine, opioids, methamphetamine, fentanyl, alcohol, and marijuana. Curre...
Shagufta Haque,Partha Dutta
Shagufta Haque
The heart-brain axis forms an important physiological network, which is increasingly gaining recognition due to its involvement in cardiac function under steady-state conditions and pathological modifications of the heart in cardiovascular ...
Autonomic mechanisms of blood pressure control in females across the lifespan [0.03%]
女性一生中心血管自主神经机制与血压调节
Qi Fu
Qi Fu
This review summarizes current knowledge on autonomic cardiovascular function, with a focus on sympathetic neural control, in human females across the lifespan in health and disease. Specifically, sympathetic activity at rest and during str...
The Molecular Foundations of High Heart Rates: Sarcomeric Protein Adaptations [0.03%]
高心率的分子基础：肌丝蛋白适应性变化
William Joyce
William Joyce
From shrews to whales, mammals exhibit a range of heart rates that varies more than 100-fold. Whilst the fundamental processes of cardiac contraction are conserved, the repertoire of contractile proteins of the sarcomere must be optimized t...