Advances in complement research: from pathophysiology to precision medicine [0.03%]
补体研究进展：从发病机制到精准医学
Joshua M Thurman
Joshua M Thurman
The complement cascade is an evolutionarily ancient system of soluble and cell bound proteins. Activation of the system triggers sequential proteolytic steps that rapidly generate downstream protein fragments, several of which have biologic...
Fetal Hemoglobin Research and Clinical Relevance in Sickle Cell Disease [0.03%]
胎儿血红蛋白的研究及其在镰状细胞病中的临床意义
Bjorg Gudmundsdottir,John F Tisdale
Bjorg Gudmundsdottir
Sickle cell disease (SCD) is the most common monogenic disorder, globally affecting close to eight million individuals. SCD is a devastating disease where patients suffer from extreme pain due to vaso-occlusive episodes (VOEs), end-organ da...
Dan Tong
Dan Tong
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity, mortality and health care expenditures. Increasing evidence has demonstrated that AF is a rather late-stage clinical manifestatio...
Sinibaldo Romero Arocha
Sinibaldo Romero Arocha
Compartmentalized nutrient and hormone sensing in β-cells: the role of cilia [0.03%]
β细胞中的营养物质和激素的区室化感应：纤毛的作用
Jing W Hughes,Matthew J Merrins
Jing W Hughes
Pancreatic β-cells couple nutrient and hormone sensing to insulin release. Prevailing models depict the β-cell as a homogeneous metabolic unit, overlooking specialized subcellular compartments like the primary cilium. Primary cilia are se...
David Tawiah
David Tawiah
Bong Ihn Koh,Ralf Adams
Bong Ihn Koh
Recent studies have uncovered that the calvarial bone marrow (BM), located within the skull, functions as a specialized hematopoietic niche distinct from BM in long bones. This compartment supports a unique repertoire of immune cells, parti...
Abida Islam Pranty,Sara Cuevas Ocaña,Jennifer A Dickens
Abida Islam Pranty
Pulmonary surfactant is a lipoproteinaceous material secreted exclusively by alveolar type 2 cells into the alveolar space. It is primarily responsible for reducing the work of breathing by reducing surface tension at the air-liquid interfa...
Dong Jiang,Li Yu
Dong Jiang
Migrasomes are specialized organelle that form during cell migration and play a critical role in intercellular communication and disease progression. First discovered in 2012 and reported in 2015, these organelles are characterized by their...
Tension to Translation: External to Internal Processes in Muscle Hypertrophy [0.03%]
从张力到翻译：肌肉肥大过程中外部刺激与内部反应的关系
Dominique Greyvenstein,James P Newbold,Stuart M Phillips
Dominique Greyvenstein
Skeletal muscle is a highly adaptable tissue that plays a central role in overall health. The dynamic balance between muscle protein synthesis and breakdown governs skeletal muscle mass maintenance. Increased loading and hyperaminoacidemia ...