Multiple Facets and Roles of Na+-K+-Cl- Cotransport: Mechanisms and Therapeutic Implications [0.03%]
Na+-K+-Cl-同向转运的多重特性和角色：机制及其治疗意义
A P Garneau,S Slimani,M J Fiola et al.
A P Garneau et al.
The Na+-K+-Cl- cotransporters play key physiological and pathophysiological roles by regulating the membrane potential of many cell types and the movement of fluid across a variety of epithelial or endothelial structures. As such, they shou...
The Pathophysiology of Rett Syndrome With a Focus on Breathing Dysfunctions [0.03%]
瑞特综合征的病理生理学，特别关注呼吸功能障碍
Jan-Marino Ramirez,Marlusa Karlen-Amarante,Jia-Der Ju Wang et al.
Jan-Marino Ramirez et al.
Rett syndrome (RTT), an X-chromosome-linked neurological disorder, is characterized by serious pathophysiology, including breathing and feeding dysfunctions, and alteration of cardiorespiratory coupling, a consequence of multiple interrelat...
Phenotypic Frailty Assessment in Mice: Development, Discoveries, and Experimental Considerations [0.03%]
小鼠表型脆弱性的评估：发展、发现和实验因素的考量
Cory W Baumann,Dongmin Kwak,LaDora V Thompson
Cory W Baumann
The underlying mechanisms contributing to the onset of frailty, its progression, and its mortality risk remain unknown. Recently, the two most common human frailty assessments were reverse-translated to mice. Here, we highlight the developm...
Barbara Palkovic,Vitaliy Marchenko,Edward J Zuperku et al.
Barbara Palkovic et al.
Opioids depress minute ventilation primarily by reducing respiratory rate. This results from direct effects on the preBötzinger Complex as well as from depression of the Parabrachial/Kölliker-Fuse Complex, which provides excitatory drive ...
Exercise-Pharmacology Interactions: Metformin, Statins, and Healthspan [0.03%]
运动与药理学的相互作用：二甲双胍、他汀类药物与健康跨度
Benjamin F Miller,John P Thyfault
Benjamin F Miller
There is an increased focus on treatments to extend the healthspan. There is solid evidence that exercise extends the healthspan, but other treatments, such as metformin and statins, are also gaining traction. If metformin and statins will ...
Physiology in Perspective: A Key Role of Physiology in Understanding COVID-19 [0.03%]
生理学的视角：在理解COVID-19中生理学的关键作用
Gary C Sieck
Gary C Sieck
Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression [0.03%]
COVID-19的病理生理学：导致疾病严重性和进展的机制
Mary Kathryn Bohn,Alexandra Hall,Lusia Sepiashvili et al.
Mary Kathryn Bohn et al.
The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well chara...
Jaladanki N Rao,Lan Xiao,Jian-Ying Wang
Jaladanki N Rao
Polyamines regulate a variety of physiological functions and are involved in pathogenesis of diverse human diseases. The epithelium of the mammalian gut mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved ...
The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology [0.03%]
SLC25载体家族：线粒体生理和病理中的重要转运蛋白
Edmund R S Kunji,Martin S King,Jonathan J Ruprecht et al.
Edmund R S Kunji et al.
Members of the mitochondrial carrier family (SLC25) transport a variety of compounds across the inner membrane of mitochondria. These transport steps provide building blocks for the cell and link the pathways of the mitochondrial matrix and...
Advanced Modeling of Peripheral Neuro-Effector Communication and -Plasticity [0.03%]
外周神经效应器通讯及可塑性的高级建模
Pien A Goldsteen,Amalia M Dolga,Reinoud Gosens
Pien A Goldsteen
The peripheral nervous system (PNS) plays crucial roles in physiology and disease. Neuro-effector communication and neuroplasticity of the PNS are poorly studied, since suitable models are lacking. The emergence of human pluripotent stem ce...