Mark Shaaya,Jordan Fauser,Andrei V Karginov
Mark Shaaya
Dissection of cell signaling requires tools that can mimic spatiotemporal dynamics of individual pathways in living cells. Optogenetic methods enable manipulation of signaling processes with precise timing and local control. In this review,...
Lauren G Douma,Dominique Barral,Michelle L Gumz
Lauren G Douma
The peptide hormone endothelin-1 and its receptors are linked to several disease states. Pharmacological inhibition of this pathway has proven beneficial in pulmonary hypertension, yet its potential in other disease states remains to be rea...
Collin M Douglas,Stuart J Hesketh,Karyn A Esser
Collin M Douglas
For more than 20 years, physiologists have observed a morning-to-evening increase in human muscle strength. Recent data suggest that time-of-day differences are the result of intrinsic, nonneural, muscle factors. We evaluate circadian clock...
Nicholas D Buchanan,David M Aslaner,Jeremy Adelstein et al.
Nicholas D Buchanan et al.
Physiology in Perspective: The Rhythm of Life-Circadian Patterns in Physiology [0.03%]
生理学概论：生命节律-生理节律学
Gary C Sieck
Gary C Sieck
Nondipping Blood Pressure: Predictive or Reactive Failure of Renal Sodium Handling? [0.03%]
非勺型血压：肾钠处理的预测性或反应性失败？
Jessica R Ivy,Matthew A Bailey
Jessica R Ivy
Blood pressure follows a daily rhythm, dipping during nocturnal sleep in humans. Attenuation of this dip (nondipping) is associated with increased risk of cardiovascular disease. Renal control of sodium homeostasis is essential for long-ter...
Sandra Crnko,Hilde Schutte,Pieter A Doevendans et al.
Sandra Crnko et al.
Circadian rhythm exerts a critical role in mammalian health and disease. A malfunctioning circadian clock can be a consequence, as well as the cause of several pathophysiologies. Clinical therapies and research may also be influenced by the...
Linda C Samuelson,Meredith Hay,Jennifer Pollock
Linda C Samuelson
Gary C Sieck
Gary C Sieck
Thomas E Taylor-Clark
Thomas E Taylor-Clark
Air pollutants pose a serious worldwide health hazard, causing respiratory and cardiovascular morbidity and mortality. Pollutants perturb the autonomic nervous system, whose function is critical to cardiopulmonary homeostasis. Recent studie...