Targeting Parasympathetic Activity to Improve Autonomic Tone and Clinical Outcomes [0.03%]
针对副交感神经活性以改善自主神经张力和临床预后
Matthew W Kay,Vivek Jain,Gurusher Panjrath et al.
Matthew W Kay et al.
In this review we will briefly summarize the evidence that autonomic imbalance, more specifically reduced parasympathetic activity to the heart, generates and/or maintains many cardiorespiratory diseases and will discuss mechanisms and site...
Therapeutic Targeting of Hypoxia-A2-Adenosinergic Pathway in COVID-19 Patients [0.03%]
针对COVID-19患者的缺氧A2腺苷受体通路的治疗靶点研究
Katarina Halpin-Veszeleiova,Stephen M Hatfield
Katarina Halpin-Veszeleiova
The hypoxia-hypoxia-inducible factor (HIF)-1α-A2-adenosinergic pathway protects tissues from inflammatory damage during antipathogen immune responses. The elimination of this physiological tissue-protecting mechanism by supplemental oxygen...
What Evolutionary Evidence Implies About the Identity of the Mechanoelectrical Couplers in Vascular Smooth Muscle Cells [0.03%]
进化证据对血管平滑肌细胞力学生化耦合因子身份的启示
Heather A Drummond
Heather A Drummond
Loss of pressure-induced vasoconstriction increases susceptibility to renal and cerebral vascular injury. Favored paradigms underlying initiation of the response include transient receptor potential channels coupled to G protein-coupled rec...
Physiology in Perspective [0.03%]
从宏观角度谈生理学
Christopher G England
Christopher G England
Karan H Muchhala,Joanna C Jacob,Minho Kang et al.
Karan H Muchhala et al.
Bidirectional interactions of the gut epithelium with commensal bacteria are critical for maintaining homeostasis within the gut. Chronic opioid exposure perturbs gut homeostasis through a multitude of neuro-immune-epithelial mechanisms, re...
Scott M Smith,Sara R Zwart
Scott M Smith
History books are rife with examples of the role of nutrition in determining either the success or the failure of human exploration on Earth. With planetary exploration in our future, it is imperative that we understand the role of nutritio...
More than Breathing Air: Evolutionary Drivers and Physiological Implications of an Amphibious Lifestyle in Fishes [0.03%]
除了呼吸空气：鱼类两栖生活方式的进化驱动力及生理意义
Andy J Turko,Giulia S Rossi,Patricia A Wright
Andy J Turko
Amphibious and aquatic air-breathing fishes both exchange respiratory gasses with the atmosphere, but these fishes differ in physiology, ecology, and possibly evolutionary origins. We introduce a scoring system to characterize interspecific...
Halogen-Induced Chemical Injury to the Mammalian Cardiopulmonary Systems [0.03%]
卤族元素引起的哺乳动物心肺系统化学损伤
Dylan R Addis,Saurabh Aggarwal,Ahmed Lazrak et al.
Dylan R Addis et al.
The halogens chlorine (Cl2) and bromine (Br2) are highly reactive oxidizing elements with widespread industrial applications and a history of development and use as chemical weapons. When inhaled, depending on the dose and duration of expos...
Michael J Caplan
Michael J Caplan
Kimberley C W Wang,Alan L James,Peter B Noble
Kimberley C W Wang
Trajectories of airway remodeling and functional impairment in asthma are consistent with the notion that airway pathology precedes or coincides with the onset of asthma symptoms and may be present at birth. An association between intrauter...