Carmen Hinojosa-Laborde,Ian L Hudson,Evan Ross et al.
Carmen Hinojosa-Laborde et al.
Saving lives of wounded military warfighters often depends on the ability to resolve or mitigate the pathophysiology of hemorrhage, specifically diminished oxygen delivery to vital organs that leads to multiorgan failure and death. However,...
Elizabeth A Stewart,Romana A Nowak
Elizabeth A Stewart
Uterine fibroids (leiomyomas) are present in >75% of women and can cause serious morbidity. They are by far the leading cause of hysterectomy. Fibroids are a complex mixture of cells that include fibroblasts and smooth muscle cells. Rich in...
From "Hunger Hormone" to "It's Complicated": Ghrelin Beyond Feeding Control [0.03%]
从"饥饿激素"到"说来复杂": 胃生长抑素在进食控制之外的作用
Sara L Deschaine,Lorenzo Leggio
Sara L Deschaine
Discovered as a peptide involved in releasing growth hormone, ghrelin was initially characterized as the "hunger hormone." However, emerging research indicates that ghrelin appears to play an important part in relaying information regarding...
Carotid Body Inflammation: Role in Hypoxia and in the Anti-inflammatory Reflex [0.03%]
颈动脉体炎症：在低氧和抗炎反射中的作用
Rodrigo Iturriaga,Rodrigo Del Rio,Julio Alcayaga
Rodrigo Iturriaga
Emergent evidence indicates that the carotid body (CB) chemoreceptor may sense systemic inflammatory molecules and is an afferent arm of the anti-inflammatory reflex. Moreover, a proinflammatory milieu within the CB is involved in the enhan...
The Opto-Respiratory Compromise: Balancing Oxygen Supply and Light Transmittance in the Retina [0.03%]
光电呼吸折衷：视网膜中氧气供应和光线透射的平衡
Christian Damsgaard,Michael W Country
Christian Damsgaard
The light-absorbing retina has an exceptionally high oxygen demand, which imposes two conflicting needs: high rates of blood perfusion and an unobstructed light path devoid of blood vessels. This review discusses mechanisms and physiologica...
Jennifer S Pollock,Linda Samuelson,Dee Silverthorn
Jennifer S Pollock
Physiology in Perspective [0.03%]
生理学的展望
Nikki Forrester
Nikki Forrester
Insulin, Muscle Glucose Uptake, and Hexokinase: Revisiting the Road Not Taken [0.03%]
胰岛素、肌肉葡萄糖摄取和己糖激酶：重新审视未选择的研究路径
David H Wasserman
David H Wasserman
Research conducted over the last 50 yr has provided insight into the mechanisms by which insulin stimulates glucose transport across the skeletal muscle cell membrane Transport alone, however, does not result in net glucose uptake as free g...
Gary L Pierce,Thais A Coutinho,Lyndsey E DuBose et al.
Gary L Pierce et al.
Aortic stiffness increases with advancing age, more than doubling during the human life span, and is a robust predictor of cardiovascular disease (CVD) clinical events independent of traditional risk factors. The aorta increases in diameter...
Paul A Janmey,Boris Hinz,Christopher A McCulloch
Paul A Janmey
Cells spread on surfaces and within three-dimensional (3-D) matrixes as they grow, divide, and move. Both chemical and physical signals orchestrate spreading during normal development, wound healing, and pathological states such as fibrosis...