Erin R Gardner,Gregory S Kopf,Jochen Buck et al.
Erin R Gardner et al.
Soluble adenylyl cyclase (sAC; ADCY10) is an evolutionarily ancient, intracellular source of cAMP that is molecularly and mechanistically distinct from the more widely studied, hormone-responsive, G protein regulated transmembrane adenylyl ...
Denis P Blondin
Denis P Blondin
Human brown adipose tissue (BAT) has emerged as a metabolically dynamic organ with the potential to influence thermoregulation, substrate utilization, and cardiometabolic health. This review synthesizes current knowledge on the biomolecular...
Misheelt Bayarsaikhan,Michael James Boyle,Phoebe V Demers et al.
Misheelt Bayarsaikhan et al.
Ancient DNA (aDNA) enables the reconstruction of chronologically sampled genomes from ancient humans, animals, plants, pathogens, and microorganisms, as well as environmental DNA, providing a record of biological changes through time. Impro...
Qianqian Bi,Guo Cheng,Ningting Chen et al.
Qianqian Bi et al.
Microglia are the major resident immune cells in the central nervous system (CNS). They emerge at very early stages of brain development and subsequently expand and persist through self-renewal within the CNS. As a result, microglial behavi...
mRNA translation and proteasomal degradation in health and neurological disease [0.03%]
健康状态与神经性疾病下的信使核糖核酸翻译与蛋白酶体降解
Alinny R Isaac,Danielle Cozachenco,Beatriz de A Wagner et al.
Alinny R Isaac et al.
The homeostasis of cellular proteins, i.e., proteostasis, is critical for neuronal function and brain processes. Proteostasis comprises a set of cellular mechanisms that control protein synthesis, folding, post-translational modification an...
Physiology in Perspective [0.03%]
从宏观角度谈生理学
Amanda Heidt
Amanda Heidt
Robert L Hester,Timothy Musch,Sue C Bodine
Robert L Hester
The Quiet Storm: Unlocking the Hidden Rhythms of Sleep to Treat Insomnia [0.03%]
静谧之雨：解锁隐秘的睡眠节奏以治疗失眠症
Ananya Dwivedi
Ananya Dwivedi
Metabolic programming of β-cell fate, state and function through time and space [0.03%]
时空中的β细胞命运、状态和功能的代谢编程
Tara MacDonald,Susan Bonner-Weir
Tara MacDonald
β-cells maintain glucose homeostasis by adjusting insulin secretion to meet the demands of (patho)physiological triggers; yet, they also undergo energy-dependent transitions between proliferation, differentiation and maturation that underl...
Organelle dysfunction and TNT-mediated aggregate spreading in neurodegeneration [0.03%]
神经退行性疾病中细胞器功能障碍与TNT介导的聚集物扩散
Valentine Thomas,Chiara Zurzolo
Valentine Thomas
Organelle dysfunction is a central hallmark of neurodegenerative diseases (NDs), which are characterized by the pathological accumulation of misfolded proteins capable of inducing aggregation in healthy cells. This process generates a self-...