Augusto C Montezano,Raquel D Sarafian,Francisco J Rios et al.
Augusto C Montezano et al.
High blood pressure (hypertension) is a complex, multifactorial and multisystem disorder and a leading cause of morbidity and premature death worldwide. It is the major modifiable risk factor for heart disease, stroke and kidney disease. Th...
Benjamin Kelly,Tobias Wang,Vibeke E Hjortdal et al.
Benjamin Kelly et al.
The lymphatic system plays a fundamental role in cardiovascular physiology by maintaining whole-body fluid balance, facilitating immune trafficking, and enabling lipid transport. Through these functions, lymphatic performance is tightly cou...
David C Andrade,Camila Salazar-Ardiles,Bayron García-Ordenes et al.
David C Andrade et al.
Human acclimatization to both high-altitude and microgravity is crucial for terrestrial and space exploration. Although these extreme environments elicit several similar physiological responses, including autonomic imbalance, metabolic stre...
Manami Katoh,Seitaro Nomura,Toshiyuki Ko et al.
Manami Katoh et al.
Heart failure (HF) remains a leading cause of morbidity and mortality worldwide despite major advances in pharmacological and device-based therapies. A central limitation of current treatments is their predominant focus on neurohumoral modu...
Optimized Cardiac Health by Exercise: Cardiomyocytes and Immune Microenvironment [0.03%]
运动优化心脏健康：心肌细胞与免疫微环境
Shuqin Liu,Meiyu Hu,Xinpeng Li et al.
Shuqin Liu et al.
Exercise is a highly cost-effective and non-pharmacological intervention for maintaining cardiovascular health and treating heart diseases. Exercise can protect the heart through multiple effects, including regulations of cardiomyocytes and...
Mackenzie K Kui,Jessica J Zhang,Jennifer L Pluznick
Mackenzie K Kui
GPCRs serve to coordinate renal collecting duct function, orchestrating fine-tuned regulation of water, electrolyte, and acid-base homeostasis. Classical GPCRs such as the vasopressin V2 receptor (V2R) have well-established roles: the V2R s...
Regulatory and Physiological Roles of lncRNAs in Tumor Immunotherapy Response [0.03%]
长链非编码RNA在肿瘤免疫治疗反应中的调控和生理作用
Miriam G Jasiulionis,Eduardo M Reis
Miriam G Jasiulionis
Immunotherapy harnesses the patient's immune system to recognize and eliminate malignant cells and constitutes the forefront of cancer therapies. Notwithstanding, intrinsic and acquired immunotherapy resistance mechanisms operating within t...
Ana D Alcocer,Elizabeth H Rush,Timothy J Mead
Ana D Alcocer
The ADAMTS family are extracellular matrix (ECM) proteins and enzymes involved in regulating tissue structure and function. The ECM is a network of proteins and polysaccharides surrounding the cells that provide support and maintain cellula...
The impact of antigen presentation on BBB disruption and neuroinflammation [0.03%]
抗原呈现在血脑屏障破坏和神经炎症中的作用
Mark A Maynes,Aaron J Johnson
Mark A Maynes
Blood brain barrier (BBB) disruption is a potentially deadly complication of numerous neurological diseases as diverse as cerebral malaria, dengue hemorrhagic fever, tauopathies, multiple sclerosis, schizophrenia, Parkinson's disease, narco...