Logic of the Temporal Compartmentalization of the Hepatic Metabolic Cycle [0.03%]
肝脏代谢周期时间隔室化的逻辑分析模型研究
Bokai Zhu
Bokai Zhu
The mammalian liver must cope with various metabolic and physiological changes that normally recur every day and result primarily from rest-activity and fasting-feeding cycles. In this article, I present evidence supporting a temporal compa...
James F Staples,Katherine E Mathers,Brynne M Duffy
James F Staples
Hibernators rapidly and reversibly suppress mitochondrial respiration and whole animal metabolism. Posttranslational modifications likely regulate these mitochondrial changes, which may help conserve energy in winter. These modifications ar...
Cold Exposure and the Metabolism of Mice, Men, and Other Wonderful Creatures [0.03%]
冷暴露与小鼠、人类及其他生物的代谢
Alicia J Kowaltowski
Alicia J Kowaltowski
Laboratory rodents and cold-adapted animals in the wild use a significant amount of the energy derived from food intake for heat generation. Thermogenesis involving mitochondrial uncoupling in the brown adipose tissue differs quantitatively...
P A Fletcher,I Marinelli,R Bertram et al.
P A Fletcher et al.
In fasted and fed states, blood insulin levels are oscillatory. While this phenomenon is well studied at high glucose levels, comparatively little is known about its origin under basal conditions. We propose a possible mechanism for basal i...
Physiology in Perspective [0.03%]
从宏观角度出发看生理学
Nikki Forrester
Nikki Forrester
Ruth Röck,Ludovica Rizzo,Soeren S Lienkamp
Ruth Röck
The kidney is a complex organ, and how it forms is a fascinating process. New technologies, such as single-cell transcriptomics, and enhanced imaging modalities are offering new approaches to understand the complex and intertwined processes...
Physiology in Perspective [0.03%]
从宏观角度解读生理学
Christopher England
Christopher England
Getting Fit to Counteract Cognitive Aging: Evidence and Future Directions [0.03%]
延缓认知衰老的体能训练：现状与未来方向
Michelle W Voss,Shivangi Jain
Michelle W Voss
Physical activity has shown tremendous promise for counteracting cognitive aging, but also tremendous variability in cognitive benefits. We describe evidence for how exercise affects cognitive and brain aging, and whether cardiorespiratory ...
Jessica L Bradshaw,Spencer C Cushen,Nicole R Phillips et al.
Jessica L Bradshaw et al.
Circulating cell-free mitochondrial DNA (ccf-mtDNA) released upon cell injury or death stimulates diverse pattern recognition receptors to activate innate immune responses and initiate systemic inflammation. In this review, we discuss the t...
High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses [0.03%]
高原红细胞增多症：适应性与非适应性反应机制
Francisco C Villafuerte,Tatum S Simonson,Daniela Bermudez et al.
Francisco C Villafuerte et al.
Erythrocytosis, or increased production of red blood cells, is one of the most well-documented physiological traits that varies within and among in high-altitude populations. Although a modest increase in blood O2-carrying capacity may be b...