Kv1.3 K+ Channel Physiology Assessed by Genetic and Pharmacological Modulation [0.03%]
基因和药理学调控下的Kv1.3钾通道生理学评估
Tatiana Varanita,Beatrice Angi,Valentina Scattolini et al.
Tatiana Varanita et al.
Potassium channels are widespread over all kingdoms and play an important role in the maintenance of cellular ionic homeostasis. Kv1.3 is a voltage-gated potassium channel of the Shaker family with a wide tissue expression and a well-define...
Physiology in Perspective [0.03%]
从宏观角度理解生理学
Nikki Forrester
Nikki Forrester
Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease [0.03%]
自由脂肪酸受体4的信号传导可减轻心血管代谢疾病
Timothy D O&#x;Connell,Katherine A Murphy,Naixin Zhang et al.
Timothy D O&#x;Connell et al.
A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-polyuns...
Ottavia M Delmonte,Riccardo Castagnoli,Luigi D Notarangelo
Ottavia M Delmonte
Inborn errors of immunity (IEI) are a heterogeneous group of disorders affecting immune host defense and immunoregulation. Considering the predisposition to develop severe and chronic infections, it is crucial to understand the clinical evo...
Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain [0.03%]
脑间质液交换在脑内溶质输送及清除废物中的生理作用
Lucy Zhao,Allen Tannenbaum,Erik N T P Bakker et al.
Lucy Zhao et al.
This review focuses on the physiology of glymphatic solute transport and waste clearance, using evidence from experimental animal models as well as from human studies. Specific topics addressed include the biophysical characteristics of flu...
Promoting Nerve Regeneration: Electrical Stimulation, Gene Therapy, and Beyond [0.03%]
促进神经再生：电刺激、基因治疗及其他方法
Andrew L O&#x;Brien,Julie M West,Tiam M Saffari et al.
Andrew L O&#x;Brien et al.
Peripheral nerve injuries often result in life-altering functional deficits even with optimal management. Unlike the central nervous system, peripheral nerves have the ability to regenerate lost axons after injury; however, axonal regenerat...
Katlyn C Richardson,Karen Jung,Julian Pardo et al.
Katlyn C Richardson et al.
Granzymes are serine proteases previously believed to play exclusive and somewhat redundant roles in lymphocyte-mediated target cell death. However, recent studies have challenged this paradigm. Distinct substrate profiles and functions hav...
Geoffrey W Abbott
Geoffrey W Abbott
Voltage-gated potassium (Kv) channels each comprise four pore-forming α-subunits that orchestrate essential duties such as voltage sensing and K+ selectivity and conductance. In vivo, however, Kv channels also incorporate regulatory subuni...
Physiology in Perspective [0.03%]
从宏观角度谈生理学
Nikki Forrester
Nikki Forrester
What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology? [0.03%]
器官芯片在人肺生理病理学研究中的应用及其局限性
Haiqing Bai,Donald E Ingber
Haiqing Bai
The intertwined relationship between structure and function has been key to understanding human organ physiology and disease pathogenesis. An organ-on-a-chip (organ chip) is a bioengineered microfluidic cell culture device lined by living c...