Physiology in Perspective [0.03%]
生理学教程
Nikki Forrester
Nikki Forrester
Daniel Daou,Thomas G Gillette,Joseph A Hill
Daniel Daou
Heart failure with preserved ejection fraction (HFpEF) is now the most common form of heart failure and a significant public health concern for which limited effective therapies exist. Inflammation triggered by comorbidity burden is a criti...
Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on Men's Health [0.03%]
白细胞中Y染色体丢失的镶嵌模式及其对男性健康的影响
Soichi Sano,Mark C Thel,Kenneth Walsh
Soichi Sano
We present a brief introduction of loss of Y chromosome (LOY) in blood and describe the known risk factors for this condition. We then overview the associations between LOY and age-related disease traits. Finally, we discuss murine models a...
Hiroshi Maekawa,Margaret Elizabeth Fain,Koichiro Wasano
Hiroshi Maekawa
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) inflammatory pathway is a component of the innate immune system that recognizes cytosolic nucleic acids. The pathway has been implicated in several processes includin...
Staying Hydrated in Seawater [0.03%]
海水中的补水技巧
Martin Grosell,Amanda M Oehlert
Martin Grosell
Reduction of intestinal lumen osmotic pressure by the formation of Ca(Mg)CO3, "ichthyocarbonate," is essential for osmoregulation by the only vertebrate group, ray-finned fishes, widely capable of hydrating by ingesting seawater. Ichthyocar...
Roberto Bravo-Sagua,Camila Lopez-Crisosto,Alfredo Criollo et al.
Roberto Bravo-Sagua et al.
Organelles are membrane-lined structures that compartmentalize subcellular biochemical functions. Therefore, interorganelle communication is crucial for cellular responses that require the coordination of such functions. Multiple principles...
Rasmus Ern,Anna H Andreassen,Fredrik Jutfelt
Rasmus Ern
This review is focused on the questions of why fish exhibit heat failure at thermal extremes and which physiological mechanisms determine the acute upper thermal tolerance. We propose that rapid direct thermal impacts on fish act through th...
Physiology in Perspective [0.03%]
生理学的视角
Nikki Forrester
Nikki Forrester
Jae Yeon Hwang,Jean-Ju Chung
Jae Yeon Hwang
The flagellar-specific Ca2+ channel CatSper is the predominant Ca2+ entry site in mammalian sperm. CatSper-mediated Ca2+ signaling affects nearly every event that regulates sperm to acquire fertilizing capability. In this review, we summari...
Masahiro Onji,Josef M Penninger
Masahiro Onji
Receptor activator of nuclear factor-κB (RANK) and its ligand (RANKL) are key regulators of mammalian physiology such as bone metabolism, immune tolerance and antitumor immunity, and mammary gland biology. Here, we explore the multiple fun...