Federico Alessandro Ruffinatti,Giorgia Scarpellino,Giorgia Chinigò et al.
Federico Alessandro Ruffinatti et al.
The array of ion channels and transporters expressed in cell membranes, collectively referred to as the transportome, is a complex and multifunctional molecular machinery; in particular, at the plasma membrane level it finely tunes the exch...
Physiology in Perspective [0.03%]
从宏观角度理解生理学
Nikki Forrester
Nikki Forrester
Mei Li,Hongmin Wang,Xiao-Jing Zhang et al.
Mei Li et al.
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide that poses a significant threat to human health. Cardiovascular disease (CVD) is the leading cause of mortality in NAFLD patients. NAFLD and CVD ...
Surviving in an Acidifying Ocean: Acid-Base Physiology and Energetics of the Sea Urchin Larva [0.03%]
在酸化海洋中生存下来：海胆幼虫的酸碱生理和能量代谢
Marian Y Hu,Meike Stumpp
Marian Y Hu
The sea urchin larva has been used by biologists for more than a century to study the development and evolution of animals. Surprisingly, very little information has been generated regarding the physiology of this small planktonic organism....
Physiology in Perspective [0.03%]
从宏观角度谈生理学
Christopher England
Christopher England
This issue of Physiology features four excellent review articles that highlight current research and discuss untapped areas for future work across a range of topics in physiology. First, we explore the impact that the loss of the Y chromoso...
Nicolas C Hoch
Nicolas C Hoch
DNA is a remarkable biochemical macromolecule tasked with storing the genetic information that instructs life on planet Earth. However, its inherent chemical instability within the cellular milieu is incompatible with the accurate transmiss...
Systemic Reprogramming of Endothelial Cell Signaling in Metastasis and Cachexia [0.03%]
转移和恶病质条件下内皮细胞信号转导的系统性再编程
Stephanie F Preuss,Denise Grieshober,Hellmut G Augustin
Stephanie F Preuss
Proliferating cancer cells secrete a multitude of factors impacting metabolism, interorgan communication, and tumor progression. The distribution of tumor-derived factors to distant organs occurs via the circulation, which provides an exten...
Sae Aratani,Makoto Nakanishi
Sae Aratani
Cellular senescence plays a central role in aging and geriatric diseases. Senolysis is a promising new strategy that selectively kills and eliminates senescent cells to control aging. To date, various senolytic drugs have been discovered an...