Mitochondrial Calcium Regulation of Cardiac Metabolism in Health and Disease [0.03%]
健康与疾病状态下线粒体钙调控心脏代谢功能
Enrique Balderas,Sandra H J Lee,Neeraj K Rai et al.
Enrique Balderas et al.
Oxidative phosphorylation is regulated by mitochondrial calcium (Ca2+) in health and disease. In physiological states, Ca2+ enters via the mitochondrial Ca2+ uniporter and rapidly enhances NADH and ATP production. However, maintaining Ca2+ ...
Nrf2-Keap1 in Cardiovascular Disease: Which Is the Cart and Which the Horse? [0.03%]
心血管疾病中的Nrf2-Keap1：哪个是马拉车，哪个是车带马？
Neha Dhyani,Changhai Tian,Lie Gao et al.
Neha Dhyani et al.
High levels of oxidant stress in the form of reactive oxidant species are prevalent in the circulation and tissues in various types of cardiovascular disease including heart failure, hypertension, peripheral arterial disease, and stroke. He...
Neural processing without O2 and glucose delivery: from the pond to the clinic [0.03%]
无氧糖供应下的神经处理：从实验室到临床
Lara do Amaral Silva,Joseph M Santin
Lara do Amaral Silva
Neuronal activity requires a large amount of ATP, leading to a rapid collapse of brain function when aerobic respiration fails. Here, we summarize how rhythmic motor circuits in the brainstem of adult frogs, which normally have high metabol...
A New Phase for WNK Kinase Signaling Complexes as Biomolecular Condensates [0.03%]
WNK激酶信号复合物作为生物分子凝聚体的新阶段
Cary R Boyd-Shiwarski,Daniel J Shiwarski,Arohan R Subramanya
Cary R Boyd-Shiwarski
The purpose of this review is to highlight transformative advances that have been made in the field of biomolecular condensates, with special emphasis on condensate material properties, physiology, and kinases, using the With-No-Lysine (WNK...
Unraveling the Enigma of Organismal Death: Insights, Implications, and Unexplored Frontiers [0.03%]
破解有机体死亡之谜：见解、影响与未探索的前沿领域
Peter A Noble,Alexander Pozhitkov,Kanhaiya Singh et al.
Peter A Noble et al.
Significant knowledge gaps exist regarding the responses of cells, tissues, and organs to organismal death. Examining the survival mechanisms influenced by metabolism and environment, this research has the potential to transform regenerativ...
Physiology in Perspective [0.03%]
从宏观角度理解生理学
Nikki Forrester
Nikki Forrester
Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation? [0.03%]
热点聚焦：我们的大脑如何处理与 thermoception相关的正负线索？
Jose G Grajales-Reyes,Bandy Chen,David Meseguer et al.
Jose G Grajales-Reyes et al.
Whether it is the dramatic suffocating sensation from a heat wave in the summer or the positive reinforcement arising from a hot drink on a cold day; we can certainly agree that our thermal environment underlies our daily rhythms of sensati...
Synergism Between Hypothalamic Astrocytes and Neurons in Metabolic Control [0.03%]
下丘脑星形胶质细胞和神经元在代谢控制中的协同作用
Laura M Frago,Alfonso Gómez-Romero,Roberto Collado-Pérez et al.
Laura M Frago et al.
Astrocytes are no longer considered as passive support cells. In the hypothalamus, these glial cells actively participate in the control of appetite, energy expenditure, and the processes leading to obesity and its secondary complications. ...
Jean-Pierre Amoakon,Goutham Mylavarapu,Raouf S Amin et al.
Jean-Pierre Amoakon et al.
Cystic fibrosis (CF) is an inherited disorder caused by a deleterious mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Given that the CFTR protein is a chloride channel expressed on a variety of cells through...
Qi Yan,Carolina Gomis Perez,Erdem Karatekin
Qi Yan
Cell membrane tension affects and is affected by many fundamental cellular processes, yet it is poorly understood. Recent experiments show that membrane tension can propagate at vastly different speeds in different cell types, reflecting ph...