Damien Laporte,Isabelle Sagot
Damien Laporte
Quiescence is operationally defined as a reversible proliferation arrest. This cellular state is central for both organism development and homeostasis, its dysregulation causing many pathologies. The quiescent state encompasses very diverse...
Physiology in Perspective [0.03%]
从历史角度看生理学
Nikki Forrester
Nikki Forrester
Philip G D Matthews
Philip G D Matthews
Multiple insect lineages have successfully reinvaded the aquatic environment, evolving to complete either part or all of their life cycle submerged in water. While these insects vary in their reliance on atmospheric oxygen, with many having...
Cristina Sobacchi,Ciro Menale,Laura Crisafulli et al.
Cristina Sobacchi et al.
RANKL and its cognate receptor RANK are crucial regulators of bone metabolism in physiological as well as in pathological conditions. Here we go through the works that unveiled the paramount role of this signaling pathway. We focus on the R...
Beyond ATP: Metabolite Networks as Regulators of Physiological and Pathological Erythroid Differentiation [0.03%]
超越ATP：作为生理和病理红细胞分化调节者的代谢物网络
Axel Joly,Arthur Schott,Ira Phadke et al.
Axel Joly et al.
Hematopoietic stem cells (HSCs) possess the capacity for self-renewal and the sustained production of all mature blood cell lineages. It has been well established that a metabolic rewiring controls the switch of HSCs from a self-renewal sta...
Harnessing Deep Learning Methods for Voltage-Gated Ion Channel Drug Discovery [0.03%]
利用深度学习方法进行电压门控离子通道药物研发
Diego Lopez-Mateos,Brandon John Harris,Adriana Hernández-González et al.
Diego Lopez-Mateos et al.
Voltage-gated ion channels (VGICs) are pivotal in regulating electrical activity in excitable cells and are critical pharmaceutical targets for treating many diseases including cardiac arrhythmia and neuropathic pain. Despite their signific...
Factors Contributing to Heat Tolerance in Humans and Experimental Models [0.03%]
人类及其实验模型耐热性的决定因素分析研究进展
Orlando Laitano,Kentaro Oki,Nisha Charkoudian
Orlando Laitano
Understanding physiological mechanisms of tolerance to heat exposure, and potential ways to improve such tolerance, is increasingly important in the context of ongoing climate change. We discuss the concept of heat tolerance in humans and e...
Charting the Molecular Terrain of Exercise: The Power of Multi-Omic Mapping [0.03%]
绘制运动的分子图谱：多组学映射的力量
Daniel H Katz,Malene E Lindholm,Euan A Ashley
Daniel H Katz
Physical activity plays a fundamental role in human health and disease. Exercise has been shown to improve a wide variety of disease states, and the scientific community is committed to understanding the precise molecular mechanisms that un...
Giulia Soggia,Yasmin ElMaghloob,Annie-Kermen Boromangnaeva et al.
Giulia Soggia et al.
Organism health relies on cell proliferation, migration, and differentiation. These universal processes depend on cytoplasmic reorganization driven notably by the cytoskeleton and its force-generating motors. Their activity generates forces...
Hanah M Georges,Errol R Norwitz,Vikki M Abrahams
Hanah M Georges
Preterm birth remains a worldwide health concern because of ongoing challenges in prediction and prevention. Current predictors are limited by poor performance, need for invasive sampling, and an inability to identify patients in a timely f...