mRNA translation and proteasomal degradation in health and neurological disease [0.03%]
健康状态与神经性疾病下的信使核糖核酸翻译与蛋白酶体降解
Alinny R Isaac,Danielle Cozachenco,Beatriz de A Wagner et al.
Alinny R Isaac et al.
The homeostasis of cellular proteins, i.e., proteostasis, is critical for neuronal function and brain processes. Proteostasis comprises a set of cellular mechanisms that control protein synthesis, folding, post-translational modification an...
Physiology in Perspective [0.03%]
从宏观角度谈生理学
Amanda Heidt
Amanda Heidt
Robert L Hester,Timothy Musch,Sue C Bodine
Robert L Hester
The Quiet Storm: Unlocking the Hidden Rhythms of Sleep to Treat Insomnia [0.03%]
静谧之雨：解锁隐秘的睡眠节奏以治疗失眠症
Ananya Dwivedi
Ananya Dwivedi
Metabolic programming of β-cell fate, state and function through time and space [0.03%]
时空中的β细胞命运、状态和功能的代谢编程
Tara MacDonald,Susan Bonner-Weir
Tara MacDonald
β-cells maintain glucose homeostasis by adjusting insulin secretion to meet the demands of (patho)physiological triggers; yet, they also undergo energy-dependent transitions between proliferation, differentiation and maturation that underl...
Organelle dysfunction and TNT-mediated aggregate spreading in neurodegeneration [0.03%]
神经退行性疾病中细胞器功能障碍与TNT介导的聚集物扩散
Valentine Thomas,Chiara Zurzolo
Valentine Thomas
Organelle dysfunction is a central hallmark of neurodegenerative diseases (NDs), which are characterized by the pathological accumulation of misfolded proteins capable of inducing aggregation in healthy cells. This process generates a self-...
Advances in complement research: from pathophysiology to precision medicine [0.03%]
补体研究进展：从发病机制到精准医学
Joshua M Thurman
Joshua M Thurman
The complement cascade is an evolutionarily ancient system of soluble and cell bound proteins. Activation of the system triggers sequential proteolytic steps that rapidly generate downstream protein fragments, several of which have biologic...
Fetal Hemoglobin Research and Clinical Relevance in Sickle Cell Disease [0.03%]
胎儿血红蛋白的研究及其在镰状细胞病中的临床意义
Bjorg Gudmundsdottir,John F Tisdale
Bjorg Gudmundsdottir
Sickle cell disease (SCD) is the most common monogenic disorder, globally affecting close to eight million individuals. SCD is a devastating disease where patients suffer from extreme pain due to vaso-occlusive episodes (VOEs), end-organ da...
Dan Tong
Dan Tong
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity, mortality and health care expenditures. Increasing evidence has demonstrated that AF is a rather late-stage clinical manifestatio...
Sinibaldo Romero Arocha
Sinibaldo Romero Arocha