Natalie Cao,Yifan Lu,Xiaojie Qiu
Natalie Cao
Clustering the protein universe of life using DIAMOND DeepClust [0.03%]
使用DIAMOND DeepClust对生命蛋白质进行聚类
Benjamin J Buchfink,Émile Barbé,Haim Ashkenazy et al.
Benjamin J Buchfink et al.
Relating billions of proteins across the tree of life remains a challenging task for comparative biosphere genomics and artificial intelligence-driven structure prediction. Here we present DIAMOND DeepClust, a cascaded, ultra-fast clusterin...
Integration of alternative fragmentation techniques into standard LC-MS workflows using a single deep learning model enhances proteome coverage [0.03%]
利用单一深度学习模型将替代裂解技术集成到标准LC-MS工作流程中可增强蛋白质组覆盖率
Nikita Levin,Cemil Can Saylan,Joel Lapin et al.
Nikita Levin et al.
Bottom-up proteomics relies predominantly on collision-induced dissociation (CID) for peptide sequencing, which has achieved remarkable sensitivity and efficiency now enabling single-cell analysis. However, CID shows limitations in characte...
Oliver C Grant,Daniel Wentworth,Samuel G Holmes et al.
Oliver C Grant et al.
We present online three-dimensional (3D) structure-prediction tools at GLYCAM-Web ( www.glycam.org ) that can be used for generating experimentally consistent 3D structures of oligosaccharides for data interpretation, hypothesis generation,...
Yimin Zheng,Ernesto Abila,Eva Chrenková et al.
Yimin Zheng et al.
Histopathological data are foundational in both biological research and clinical diagnostics but remain siloed from modern multimodal and single-cell frameworks. Here we introduce LazySlide, an open-source Python package built on the scvers...
Open and sustainable AI: challenges, opportunities and the road ahead in the life sciences [0.03%]
开放且可持续的AI：生命科学领域面临的挑战、机遇及未来之路
Gavin Farrell,Eleni Adamidi,Rafael Andrade Buono et al.
Gavin Farrell et al.
Artificial intelligence (AI) has seen transformative breakthroughs in the life sciences, expanding possibilities to interpret biological information at an unprecedented capacity. To maximize return on growing investments and accelerate prog...
CellVoyager: AI CompBio agent generates new insights by autonomously analyzing biological data [0.03%]
细胞导航者：AI计算生物学代理通过自主分析生物数据产生新的见解
Samuel Alber,Bowen Chen,Eric Sun et al.
Samuel Alber et al.
Modern biology increasingly relies on complex, high-dimensional datasets such as single-cell RNA sequencing (scRNA-seq), which present a vast space of potential hypotheses. Systematically exploring this space is often impractical, as scRNA-...
Juexiao Zhou,Xiaonan He,Kai Kang et al.
Juexiao Zhou et al.
Pengyu Zhang,Tun Xu,Songbo Wang et al.
Pengyu Zhang et al.
Accurate gene annotation is essential for deciphering the mapping from genomic sequences to their functional roles. However, current methods struggle to model complex gene transmission patterns, such as vertical inheritance and horizontal g...