Caroline Seydel
Caroline Seydel
Vivien Marx
Vivien Marx
PASTA: versatile tyramide-oligonucleotide amplification for multimodal spatial biology [0.03%]
PASTA：用于多模式空间生物学的酪胺-寡核苷酸放大技术
Hendrik A Michel,Paige McCallum,Wenrui Wu et al.
Hendrik A Michel et al.
Spatial proteomics is limited by detection sensitivity, multiplexing and multimodal integration, leaving a gap between discovery and clinical assays. Here we present protein and nucleic acid serial tyramide amplification (PASTA), using hors...
Disruption of the research software landscape through AI software generation [0.03%]
人工智能软件生成对研究软件格局的破坏效应
Nelson D Medina,Joergen M R Kornfeld
Nelson D Medina
Aligning protein-generative models to experimental fitness with ProteinDPO [0.03%]
利用ProteinDPO模型将蛋白质生成模型与实验适应度对齐
Talal Widatalla,Ashir A Borah,Samuel H King et al.
Talal Widatalla et al.
Biological generative models can predict biological functions without task-specific training data but often under-perform specialized models. This is due to a fundamental 'alignment gap', where the rules learned during unsupervised training...
Luca Deininger,Paolo Caldarelli,Magdalena Zernicka-Goetz et al.
Luca Deininger et al.
Artificial intelligence (AI) is rapidly transforming stem cell and developmental biology, offering new strategies to analyze, interpret and optimize complex, dynamic systems such as organoids and stem cell-derived embryo models. In this Per...
Lessons learned from a Kaggle challenge for particle picking in cryo-electron tomography [0.03%]
从基于冷冻电子断层扫描的粒子挑选的Kaggle挑战中获得的经验教训
Ariana Peck,Joshua Hutchings,Jonathan Schwartz et al.
Ariana Peck et al.
The difficulty of particle picking in cryo-electron tomography remains a barrier to routine in situ structure determination. Machine learning is well suited to overcome this bottleneck with efficient algorithms that generalize across molecu...
Voltage imaging of neurons distributed across entire brains of larval zebrafish [0.03%]
整个斑马鱼幼体大脑中分散神经元的电压成像
Zeguan Wang,Jie Zhang,Panagiotis Symvoulidis et al.
Zeguan Wang et al.
Neurons interact in networks distributed throughout the brain. While much effort has focused on whole-brain calcium imaging, advances in genetically encoded voltage indicators raise the question of whether it might be possible to image neur...