DeepMVP: deep learning models trained on high-quality data accurately predict PTM sites and variant-induced alterations [0.03%]
DeepMVP：在高质量数据上训练的深度学习模型可准确预测PTM位点和变异引起的改变
Bo Wen,Chenwei Wang,Kai Li et al.
Bo Wen et al.
Post-translational modifications (PTMs) are critical regulators of protein function, and their disruption is a key mechanism by which missense variants contribute to disease. Accurate PTM site prediction using deep learning can help identif...
Reconstruction of a connectome of single neurons in mouse brains by cross-validating multi-scale multi-modality data [0.03%]
通过交叉验证多尺度多模态数据重建小鼠大脑单神经元连接组学图谱
Feng Xiong,Lijuan Liu,Hanchuan Peng
Feng Xiong
Brain networks, or connectomes, have inspired research at macro-, meso- and micro-scales. However, the rise of single-cell technologies necessitates inferring connectomes consisting of individual neurons projecting throughout the brain. Her...
A realistic phantom dataset for benchmarking cryo-ET data annotation [0.03%]
用于基准测试cryo-ET数据注释的现实phantom数据集
Ariana Peck,Yue Yu,Jonathan Schwartz et al.
Ariana Peck et al.
Cryo-electron tomography (cryo-ET) is a powerful technique for imaging molecular complexes in their native cellular environments. However, identifying the vast majority of molecular species in cellular tomograms remains prohibitively diffic...
Jordão Bragantini,Ilan Theodoro,Xiang Zhao et al.
Jordão Bragantini et al.
Tracking live cells across two-dimensional, three-dimensional (3D) and multichannel time-lapse recordings is crucial for understanding tissue-scale biological processes. Despite advancements in imaging technology, accurately tracking cells ...
inTRACKtive: a web-based tool for interactive cell tracking visualization [0.03%]
inTRACKtive：一种基于网页的交互式细胞追踪可视化工具
Teun A P M Huijben,Ashley G Anderson rd,Andrew Sweet et al.
Teun A P M Huijben et al.
A versatile miniature two-photon microscope enabling multicolor deep-brain imaging [0.03%]
一种多功能微型双光子显微镜，可实现多色深层脑成像
Runlong Wu,Chunzhu Zhao,Shan Qiu et al.
Runlong Wu et al.
Here we present FHIRM-TPM 3.0, a 2.6 g miniature two-photon microscope capable of multicolor deep-brain imaging in freely behaving mice. The system was integrated with a broadband anti-resonant hollow-core fiber featuring low transmission l...
Dina Zielinski,Assaf Gordon,Benjamin L Zaks et al.
Dina Zielinski et al.
Published Erratum
Nature methods. 2025 Aug 20. DOI:10.1038/s41592-025-02804-1 2025
Author Correction: Nanoscale optomechanical actuators for controlling mechanotransduction in living cells [0.03%]
作者更正：活细胞机械转导的纳米级光机执行器
Zheng Liu,Yang Liu,Yuan Chang et al.
Zheng Liu et al.
Published Erratum
Nature methods. 2025 Aug 19. DOI:10.1038/s41592-025-02803-2 2025
Vivien Marx
Vivien Marx