Vivien Marx
Vivien Marx
SNP calling, haplotype phasing and allele-specific analysis with long RNA-seq reads [0.03%]
基于长RNA测序读段进行SNP识别、基因型判定及等位基因特异性分析
Neng Huang,Heng Li;Human Pangenome Reference Consortium
Neng Huang
Long-read RNA sequencing is a powerful technology to link transcript structures to genetic variants, but this type of analysis is not often performed owing to the lack of end-user tools. Here we introduce longcallR for joint single-nucleoti...
Soufian Lasli,Claire Vinel,Ayushi Agrawal et al.
Soufian Lasli et al.
Oligodendrocytes enable rapid central nervous system signaling by myelinating axons. Here, to model key biomechanical cues regulating myelination, we developed a tunable hydrogel-based micropillar array system that mimics the three-dimensio...
Feng Mei,Jonah R Chan
Feng Mei
Compressing the collective knowledge of ESM into a single protein language model [0.03%]
压缩ESM的集体知识以构建单个蛋白质语言模型
Tuan Dinh,Seon-Kyeong Jang,Noah Zaitlen et al.
Tuan Dinh et al.
Protein language models (PLMs) have recently emerged as a promising approach for next-generation variant-effect prediction (VEP). Most high-performing VEP methods currently utilize PLMs combined with additional information, such as homology...
Differentiation of sphingomyelin and cholesterol by hyperspectral mid-infrared detection of single-bond vibrational modes in the fingerprint region [0.03%]
通过指纹区域单键振动模式的高光谱中红外检测区分卵磷脂和胆固醇
Francesca Gasparin,Alexander Prebeck,Alice Soldà et al.
Francesca Gasparin et al.
Lipids play a central role in a multitude of biological functions associated with cancer, obesity, diabetes, cardiovascular and neurological pathologies. However, sensing and mapping of lipid classes in living cells remains challenging. Her...
Vivien Marx
Vivien Marx
3d-OT: a deep geometry-aware framework for heterogeneous slices alignment of spatial multi-omics [0.03%]
3D-OT：一种深度几何感知框架用于空间多组学异质切片对齐问题
Bingjie Dai,Litai Yi,Peizhuo Wang et al.
Bingjie Dai et al.
The rapid advancement of spatial multi-omics technologies has unveiled opportunities for deciphering the intricate spatial heterogeneity; however, current computational approaches struggle to comprehensively integrate diverse molecular and ...