Toward a unified framework for determining conformational ensembles of disordered proteins [0.03%]
朝向确定无序蛋白质构象集合的统一框架
Hamidreza Ghafouri,Pavel Kadeřávek,Ana M Melo et al.
Hamidreza Ghafouri et al.
Disordered proteins play essential roles in myriad cellular processes, yet their structural characterization remains a major challenge due to their dynamic and heterogeneous nature. Here we present a community-driven initiative to address t...
Scaffolds with optimized quaternary symmetry for de novo cryoEM structure determination of small RNAs [0.03%]
用于从头 cryoEM 结构测定的小 RNA 的优化四级对称支架
Christopher P Jones,Adrian R Ferré-D&#x;Amaré
Christopher P Jones
Structured RNAs play many roles in cells and emerging biotechnology. While large RNAs and ribonucleoprotein complexes often benefit from high-resolution structural analysis through cryogenic-sample electron microscopy (cryoEM), single-domai...
Julian Katzke,Francisco Hita Garcia,Philipp D Lösel et al.
Julian Katzke et al.
The big data era in biology is underway, but the study of organismal form has been slow to capitalize on advances in imaging and computation. Imaging approaches can digitize whole organisms, but low throughput has limited the effort to docu...
Vivien Marx
Vivien Marx
DECODE: deep learning-based common deconvolution framework for various omics data [0.03%]
基于深度学习的多种组学数据共同去卷积框架(DECODE)
Tianyi Zhao,Renjie Liu,Yuzhi Sun et al.
Tianyi Zhao et al.
Deconvolution algorithms estimate cell-type abundances from tissue-level data, enabling systematic cellular analysis of large cohorts. However, most deconvolution algorithms are specifically designed for single-omics data, thereby limiting ...
Xiaoyu Wang,Fuyi Li,Robin B Gasser et al.
Xiaoyu Wang et al.
Next-generation multicolor indicators for in vivo imaging of norepinephrine [0.03%]
用于体内显影去甲肾上腺素的下一代多色示踪剂
Valentin Lu Rohner,Sebastiano Curreli,Paul J Lamothe-Molina et al.
Valentin Lu Rohner et al.
Norepinephrine (NE) is a critical neuromodulator that dynamically shapes brain states and behavior. Genetically encoded fluorescent NE indicators have enabled in vivo visualization of NE release, yet their limited sensitivity and spectral f...
Author Correction: Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance [0.03%]
作者更正：单细胞多组学检测DNA甲基化和组蛋白修饰可重构表观基因组维持的动态变化
Christoph Geisenberger,Jeroen van den Berg,Vincent van Batenburg et al.
Christoph Geisenberger et al.
Published Erratum
Nature methods. 2026 Feb 21. DOI:10.1038/s41592-026-03031-y 2026
Vivien Marx
Vivien Marx