Learning genes deeply [0.03%]
深度学习基因功能预测模型
Michael Hiller
Michael Hiller
Connectome-seq: high-throughput mapping of neuronal connectivity at single-synapse resolution via barcode sequencing [0.03%]
连接组测序技术：通过条形码测序在单个突触水平上高通量绘制神经元连接图谱的新方法
Danping Chen,Alina Isakova,Zhou Wan et al.
Danping Chen et al.
Understanding neuronal connectivity at single-cell resolution remains a fundamental challenge in neuroscience, with current methods particularly limited in mapping long-distance circuits and preserving cell type information. Here we present...
Isotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo [0.03%]
用于活细胞离体和在体成像的等渗及微创型光学透明介质
Shigenori Inagaki,Nao Nakagawa-Tamagawa,Nathan Zechen Huynh et al.
Shigenori Inagaki et al.
Tissue clearing has been widely used for fluorescence imaging of fixed tissues, but its application to live tissues has been limited by toxicity. Here we develop minimally invasive optical clearing media for fluorescence imaging of live mam...
Michelle Korda
Michelle Korda
Qiangwei Peng,Peijie Zhou,Tiejun Li
Qiangwei Peng
Time-series spatial transcriptomics with single-cell resolution provides an opportunity to study cell differentiation, proliferation and migration in physical space over time. However, because sequencing is destructive, reconstructing spati...
Engineering gut biosensors [0.03%]
工程肠道生物传感器
Aparna Anantharaman
Aparna Anantharaman
Fariha Rahman
Fariha Rahman
AF2BIND: predicting small-molecule binding sites using the pair representation of AlphaFold2 [0.03%]
基于AlphaFold2成对表示的小分子结合位点预测算法AF2BIND
Artem Gazizov,Anna Lian,Casper Goverde et al.
Artem Gazizov et al.
Identification of small-molecule binding sites in proteins is an important task for drug discovery. Despite previous homology- and machine-learning-based approaches to this problem, true de novo binding-site prediction remains a challenge. ...