In-dwelling microfluidic device for precise and reliable intranasal drug delivery during freely moving behavior [0.03%]
用于自由活动期间精确可靠鼻内给药的内置微流体装置
Maria F Ramirez,Abhishek Gour,Sarah E Sniffen et al.
Maria F Ramirez et al.
Many substances and drugs are administered intranasally. These include opioid overdose reversal drugs, anti-epileptic medications, migraine medications, hormone treatments and medicines to treat/prevent allergies, colds and flus, including ...
Twist1 overexpression models an aggressive subtype of pancreatic ductal adenocarcinoma in vivo [0.03%]
TWIST1过表达在胰腺导管腺癌小鼠模型中促进肿瘤的侵袭性生长
Muhammad Ajmal Khan,Jinhee Chang,Yang Song et al.
Muhammad Ajmal Khan et al.
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with poor survival outcomes. Genomic analyses have identified distinct molecular subtypes in human PDAC with the quasimesenchymal/squamous/basal-like (QSB) subtype having the worst ...
Evaluating perfusion and metabolic responses of microvascular free flaps to ischemia, reperfusion and fluid resuscitation during septic shock in a large animal model [0.03%]
大型动物模型中评估脓毒性休克期间微血管游离皮瓣对缺血、再灌注和液体复苏的灌注及代谢反应
Daniel Stephan,Alexander Ziebart,Robert Ruemmler et al.
Daniel Stephan et al.
Microvascular free flap transfer is an essential procedure in head and neck reconstructive surgery, with total flap loss representing the primary complication. Sepsis has been identified as a critical risk factor contributing to flap failur...
Publisher Correction: Multiomics characterization of an alcohol-induced hepatocellular carcinoma mouse model [0.03%]
出版更正：酒精诱导的肝细胞癌小鼠模型的多组学特征分析
Seol Hee Park,Seo Bhin Park,Jisoo Kang et al.
Seol Hee Park et al.
Published Erratum
Lab animal. 2026 May 13. DOI:10.1038/s41684-026-01749-y 2026
What's in a NAM? [0.03%]
NAM是什么样的模型？
Arti Ahluwalia,Babette Fletemeyer,Giuseppe Chirico et al.
Arti Ahluwalia et al.
The transition away from animal experimentation is gaining momentum across scientific disciplines, driven by technological advancements, ethical imperatives and policy support. At the forefront of this movement is the development of New App...
Sex-specific systemic and brain metabolic responses to a standardized ketogenic diet in mice [0.03%]
小鼠性别特异性全身和大脑代谢组对标准生酮饮食的反应
Charlotte Lorin,Giacomo Diaceri,Miguel Garcia et al.
Charlotte Lorin et al.
Ketogenic diets (KDs) are widely used in preclinical research to investigate metabolism and neurological function, yet many studies lack methodological consistency and frequently exclude female animals. Here we investigated sex-specific sys...
Alternative antibiotic regimens improve palatability and welfare in mice for gut bacterial depletion [0.03%]
替代性抗生素 regimen可改善小鼠的适口性和福利以实现肠道细菌耗竭
Kaoutar Abaakil,Yang Bi,Laetitia Firmenich et al.
Kaoutar Abaakil et al.
Here we evaluated vancomycin-neomycin or enrofloxacin-ampicillin treatments as alternatives to the poorly tolerated ampicillin-metronidazole-vancomycin-neomycin cocktail for gut bacterial depletion in mice. Both regimens were well tolerated...
Moving beyond oral gavage: micropipette-guided drug administration (MDA) as a 3R refinement for voluntary oral drug delivery in rodents [0.03%]
超越口服灌胃：作为自愿口服给药的3R精简版微吸管引导药物输送（MDA）小鼠模型中的应用研究
Frida A M Nilsson,Olga Krzyzaniak,Macsmeila Dietrich et al.
Frida A M Nilsson et al.
Alexandra Le Bras
Alexandra Le Bras
Jorge Ferreira
Jorge Ferreira