Kathryn Twigg Arrildt,Sarah Beth Joseph,Ronald Swanstrom
Kathryn Twigg Arrildt
HIV-1 is completely dependent upon the Env protein to enter cells. The virus typically replicates in activated CD4+ T cells due to viral entry requirements for the CCR5 coreceptor and for high surface levels of the CD4 receptor. This is the...
New tools for quantifying HIV-1 reservoirs: plasma RNA single copy assays and beyond [0.03%]
量化HIV-1储存库的新工具：血浆RNA单拷贝测定及其他方法
Benedict B Hilldorfer,Anthony R Cillo,Guillaume J Besson et al.
Benedict B Hilldorfer et al.
Quantification of plasma HIV-1 RNA below the limit of FDA-approved assays by a single copy quantitative PCR assays (SCA) has provided significant insights into HIV-1 persistence despite potent antiretroviral therapy as well as a means to as...
Ann J Hessell,Nancy L Haigwood
Ann J Hessell
It is now evident that powerful antibodies directed to conserved regions of HIV-1 envelope protein develop during chronic infection in some individuals and that these antibodies can neutralize a broad array of diverse isolates in vitro, so ...
Filippos Porichis,Daniel E Kaufmann
Filippos Porichis
Major advances in Antiretroviral Therapy (ART) have resulted in a dramatic decline in HIV-related deaths. However, no current treatment regimen leads to viral eradication or restoration of HIV-specific immune responses capable of durable vi...
Deepak Saxena,Yihong Li,Liying Yang et al.
Deepak Saxena et al.
Understanding of the human microbiome continues to grow rapidly; however, reports on changes in the microbiome after HIV infection are still limited. This review surveys the progress made in methodology associated with microbiome studies an...
Zana Lukic,Edward M Campbell
Zana Lukic
The tripartite motif (TRIM)-containing proteins are involved in many cellular functions such as cell signaling, apoptosis, cell differentiation, and immune modulation. TRIM5 proteins, including TRIM5α and TRIM-Cyp, are known to possess ant...
High prevalence of vitamin D deficiency in HIV-infected adults: what are the future research questions? [0.03%]
成人HIV感染者维生素D缺乏的高流行率：未来的研究方向是什么？
Temitope Oyedele,Oluwatoyin M Adeyemi
Temitope Oyedele
Rajeev Mehla,Velpandi Ayyavoo
Rajeev Mehla
HIV-1-infected individuals exhibit remarkable variation in the onset of disease. Virus replication and disease progression depend on host cellular transcription and gene regulation in virus-specific target cells. Both viral and host factors...
HIV: inflammation and bone [0.03%]
HIV与骨质炎
Ighovwerha Ofotokun,Emily McIntosh,M Neale Weitzmann
Ighovwerha Ofotokun
HIV infection and antiretroviral therapy (ART) are now established independent risk factors for osteoporosis. With a spate of recent studies reporting significant elevations in fracture prevalence in HIV patients, and a rapidly aging demogr...
Promising prevention approaches: tenofovir gel and prophylactic use of antiretroviral medications [0.03%]
前景看好的预防方法：替诺福韦凝胶和抗逆转录病毒药物的预防性使用
Douglas Krakower,Kenneth H Mayer
Douglas Krakower
Thirty years into the global HIV epidemic, the need for effective prevention strategies remains critical. In July 2010, the CAPRISA-004 study demonstrated that topical administration of a gel containing the antiretroviral agent tenofovir de...