Accelerating Low-Barrier Use of Long-Acting Antiretroviral Therapy to Maximize Impact in People with HIV and Viremia or Adherence Challenges [0.03%]
加速使用低门槛长效抗逆转录病毒药物以最大限度地提高HIV病毒血症或依从性挑战患者的治疗效果
Lauren F Collins,Casey Chmura,Morgan M Philbin et al.
Lauren F Collins et al.
Purpose of review: Long-acting (LA) antiretroviral therapy (ART) is rapidly revolutionizing the landscape of HIV treatment. Clinical trials for injectable cabotegravir/rilpivirine (CAB/RPV) only included certain populatio...
HSV, HIV, and Pregnancy: Epidemiology, Viral Interactions, Management, and Prevention [0.03%]
hsv、hiv和怀孕：流行病学、病毒相互作用、管理和预防
Sheliza Halani,Mark H Yudin,Darrell H S Tan
Sheliza Halani
Purpose of review: We summarize the epidemiology, biology, management and prevention of HSV-2 and HIV in pregnancy. Recent findings: Th...
Systemic Inflammation as a Modulator of FcRn-dependent IgG Pharmacokinetics: Implications for Broadly Neutralising Antibody Efficacy in HIV Prevention [0.03%]
FcRn依赖的IgG药物代谢动力学的系统性炎症调节：对HIV预防广谱中和抗体疗效的影响
Andile Khumalo,Sanjali Pillay,Jivanka Mohan et al.
Andile Khumalo et al.
Purpose of review: Broadly neutralising antibodies (bNAbs) represent a promising long-acting modality for HIV prevention. However, substantial interindividual pharmacokinetic variability poses a threat to real-world effic...
A Leap Forward in Vaccination - the Epigenetic Silencing of HIV by cVacc [0.03%]
疫苗研发的一次飞跃——通过cVacc表观遗传学沉默HIV病毒感染
Jielin Zhang,Philip Askenase,Clyde Crumpacker
Jielin Zhang
Purpose: More than four decades of HIV/AIDS studies reveal that generation of effective vaccines against HIV infection requires understanding of a host immunity that protects our DNA against the HIV infection. An effectiv...
IAS 2025: Why Can't I Breastfeed My Baby When Evidence and Lived Experience Say I Can? A Call for Policy Equity for Mothers Living with HIV [0.03%]
IAS 2025：为什么证据和亲身经历都说我可以母乳喂养，政策却说不可以？感染 HIV 的母亲呼吁政策平等
Ifeanyi Ngwoke,Boluwatife Owoyemi,Fisayo Alao-Amiola
Ifeanyi Ngwoke
Cytomegalovirus and HIV Co-Infections During Pregnancy and Early Childhood [0.03%]
孕期和幼儿期巨细胞病毒和HIV共感染
Swetha Pinninti,Nitin Arora,Suresh Boppana
Swetha Pinninti
Purpose of review: This review summarizes the epidemiology of Cytomegalovirus infections in children exposed to or infected with HIV and the impact of CMV infection on overall health outcomes in this population. ...
HIV Reservoirs in Brain parenchyma and Cerebrospinal Fluid During Suppressive ART: Same-Same or Very Different? [0.03%]
高效抗逆转录病毒治疗期间脑实质和脑脊液中的人免疫缺陷病毒库：同质还是异质？
Thomas A Angelovich,Janna Jamal Eddine,Emily K Chalmers et al.
Thomas A Angelovich et al.
Purpose of review: The central nervous system (CNS) remains a relatively understudied reservoir of HIV that may have significant implications for HIV cure and the pathogenesis of cognitive disorders that persist despite v...
HIV-1 Tat-driven Glutamate Dysregulation: Implications for Cognitive Impairment in HAND [0.03%]
人类免疫缺陷病毒Tat蛋白驱动的谷氨酸失调对HAND认知障碍的影响
Brenna C Duffy,Michael R Nonnemacher,Sandhya Kortagere
Brenna C Duffy
Purpose of review: HIV-1-associated neurocognitive disorders (HAND) manifest in 15% to 50% of people with HIV, impairing learning and memory and executive function. The chronic generation of HIV-1 Transactivator of transc...
Central Nervous System HIV Persistence and Clinical Consequences During Suppressive ART [0.03%]
抗病毒治疗期间中枢神经系统中的人免疫缺陷病毒感染及临床后果
Kathryn B Holroyd,Serena Spudich,Alan Winston et al.
Kathryn B Holroyd et al.
Purpose of review: This review discusses recent advances in understanding the mechanisms of CNS HIV invasion and persistence and examines how these processes relate to the neurologic complications of HIV. ...
Angela Tembo,Tarryn Collings,Tsitsi Nyamuzihwa et al.
Angela Tembo et al.