Therapeutic options for low bone mineral density in HIV-infected subjects [0.03%]
人类免疫缺陷病毒感染者的低骨密度治疗方案
Aoife G Cotter,Patrick W G Mallon
Aoife G Cotter
With the advent of effective antiretroviral therapy (ART), the recognition and management of long-term complications of HIV infection and ART are increasingly important for HIV physicians. Low bone mineral density (BMD) is more common in th...
Mariam Aziz,Kimberly Y Smith
Mariam Aziz
While antiretroviral therapy (ART) has had a tremendous impact on the morbidity and mortality of patients with HIV, there is evidence that many HIV-infected women experience treatment challenges that are different from men and these challen...
Alain Lafeuillade
Alain Lafeuillade
In the past few years, major advances have been achieved in understanding the nature and the maintenance mechanisms of the HIV reservoir. Although antiretroviral therapy works well in a majority of patients, it faces problems of compliance,...
Kathryn Curran,Jared M Baeten,Thomas J Coates et al.
Kathryn Curran et al.
A substantial proportion of HIV-1 infected individuals in sub-Saharan Africa are in stable relationships with HIV-1 uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Co...
Meagan O&#x;Brien,Martin Markowitz
Meagan O&#x;Brien
Critical advances in the early diagnosis of HIV now allow for treatment opportunities during acute infection. It remains unclear whether treatment of acute HIV infection with antiretroviral therapy improves long-term clinical outcomes for t...
Lene Ryom,Amanda Mocroft,Jens Lundgren
Lene Ryom
Several observational studies have identified tenofovir as an independent risk factor for kidney impairment. Conversely, randomized trials have only demonstrated minor tenofovir-related changes in kidney function, but these studies included...
Miriam Estébanez,Jose R Arribas
Miriam Estébanez
Protease inhibitor monotherapy has been shown to be effective in maintaining long-term viral suppression in a majority of patients. Withdrawal of nucleoside analogues can prevent long-term toxicity related to these drugs. Clinical trials ha...
Ziba Jalali,Jürgen K Rockstroh
Ziba Jalali
With effective treatment of HIV-1, hepatitis C virus (HCV) has become increasingly recognized as a major cause of morbidity and mortality in this population. Rapid progression of liver disease and cirrhosis has been documented in HIV/HCV co...
Miranda Z Smith,Fiona Wightman,Sharon R Lewin
Miranda Z Smith
Combination antiretroviral therapy (cART) has led to a reduction in morbidity and mortality in HIV-infected patients but therapy is lifelong and there is no cure for HIV. The major barriers to cure include HIV latency, which has been identi...
Maria Teresa Maidana Giret,Esper Georges Kallas
Maria Teresa Maidana Giret
The GB virus C is a common non-pathogenic virus, member of the Flaviviridae family with worldwide distribution. Favorable clinical course and reduced mortality among HIV-infected patients was demonstrated by several studies with patients co...