A T-dependent antibody response evaluation in CD-1 mice after an acute whole-body inhalation exposure to nickel (II) chloride hexahydrate [0.03%]
急性全身吸入氯化镍(II)六水合物后CD-1小鼠T依赖性抗体反应评价
Samuel Buxton,Michael D Taylor,Jeffrey T Weinberg et al.
Samuel Buxton et al.
Nickel (Ni) in ambient air may vary regionally with contributions from both natural processes and anthropogenic activities. Exposure to Ni compounds in ambient air above a certain level is associated with acute adverse effects, such as uppe...
Highly sensitive in vitro cytokine release assay incorporating high-density preculture [0.03%]
包含高密度预培养的高灵敏度体外细胞因子释放试验
Shiho Ito,Kyoko Miwa,Chiharu Hattori et al.
Shiho Ito et al.
Immunostimulatory effects of monoclonal antibodies (mAb) through binding to Fcγ receptors (FcγR) on immune cells are a likely cause of cytokine release syndrome. However, it is difficult to detect the potential risk of FcγR-dependent cyt...
Safety and efficacy of using heat-killed Lactobacillus plantarum L-137: High-dose and long-term use effects on immune-related safety and intestinal bacterial flora [0.03%]
使用热灭活的Lactobacillus plantarum L-137的安全性和有效性：高剂量和长期使用对免疫相关安全性和肠道细菌菌群的影响
Hiroko Nakai,Shinji Murosaki,Yoshihiro Yamamoto et al.
Hiroko Nakai et al.
Heat-killed Lactobacillus plantarum L-137 (HK L-137) promotes immune function in animals. In healthy people, T-cell proliferation was shown to be enhanced by taking 10 mg HK L-137 daily for 12 weeks. However, the safety and efficacy of high...
Epicutaneous challenge with protease allergen requires its protease activity to recall TH2 and TH17/TH22 responses in mice pre-sensitized via distant skin [0.03%]
外源性蛋白酶过敏原致敏小鼠的激发反应依赖于其蛋白酶活性以再次募集TH2和TH17 / TH22免疫应答
Akira Ogasawara,Takuo Yuki,Toshiro Takai et al.
Akira Ogasawara et al.
Epicutaneous exposure to allergenic proteins is an important sensitization route for skin diseases like protein contact dermatitis, immunologic contact urticaria, and atopic dermatitis. Environmental allergen sources such as house dust mite...
Exposure to a mixture of 23 chemicals associated with unconventional oil and gas operations alters immune response to challenge in adult mice [0.03%]
23种非常规油气作业相关化学物质的混合物暴露会改变小鼠的免疫应答
Colleen T O&#x;Dell,Lisbeth A Boule,Jacques Robert et al.
Colleen T O&#x;Dell et al.
The prevalence of unconventional oil and gas (UOG) operations raises concerns regarding the potential for adverse health outcomes following exposure to water tainted by mixtures of UOG associated chemicals. The potential effects that exposu...
Dietary advanced glycation end-products elicit toxicological effects by disrupting gut microbiome and immune homeostasis [0.03%]
膳食晚期糖基化终产物通过扰乱肠道微生物组和免疫稳态而产生毒性效应
Yingjia Chen,Tai L Guo
Yingjia Chen
The aging immune system is characterized by a low-grade chronic systemic inflammatory state ("inflammaging") marked by elevated serum levels of inflammatory molecules such as interleukin (IL)-6 and C-reactive protein (CRP). These inflammato...
Immunotoxicity studies of sulfolane following developmental exposure in Hsd:Sprague Dawley SD rats and adult exposure in B6C3F1/N mice [0.03%]
硫基四氢呋喃的免疫毒性研究——以SD大鼠和B6C3F1/N小鼠为模型
AtLee T D Watson,Victor J Johnson,Michael I Luster et al.
AtLee T D Watson et al.
Sulfolane is a solvent used in the petrochemical industry and a groundwater contaminant in areas near refineries. The current studies were conducted to assess the impact of oral exposure to sulfolane on the immune system using two models: (...
Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands [0.03%]
远端岛国成人接触含氟化合物与体内疫苗浓度的关系：一项基于出生队列的研究
Yu-Hsuan Shih,Annelise J Blomberg,Marie-Abèle Bind et al.
Yu-Hsuan Shih et al.
Per- and polyfluoroalkyl substances (PFASs) are highly persistent in the environment and may cause depressed immune function. Previous studies have linked PFAS exposure to lower vaccine responses in children, but research in adults is limit...
Impact of mono-culture vs. Co-culture of keratinocytes and monocytes on cytokine responses induced by important skin sensitizers [0.03%]
单一培养和混合培养的角质形成细胞与单核细胞诱导皮肤致敏物细胞因子反应的影响分析
Venkatanaidu Karri,Carola Lidén,Nanna Fyhrquist et al.
Venkatanaidu Karri et al.
Sensitization to a contact allergen brings with it a lifelong risk to develop allergic contact dermatitis. Inflammation is an important part of the skin sensitizing mechanism, and understanding how different haptens stimulate the immune sys...
Adverse immunological responses against non-viral nanoparticle (NP) delivery systems in the lung [0.03%]
肺部针对非病毒纳米颗粒(NP)递送系统的不良免疫反应
Leonor de Braganca,G John Ferguson,Jose Luis Santos et al.
Leonor de Braganca et al.
There is a large, unmet medical need to treat chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis and other respiratory diseases. New modalities are being developed, including gene therapy which treats the disease a...