Seasonal variation in cytokine profiles in atopic dermatitis patients treated with dupilumab [0.03%]
dupilumab治疗特应性皮炎患者细胞因子谱的季节性变化
Jarmila Čelakovská,Eva Čermáková,Petra Boudkova et al.
Jarmila Čelakovská et al.
Atopic dermatitis (AD) is primarily a TH2-driven pathology, yet seasonal factors may activate additional immune pathways. This study examined seasonal variation in plasma cytokines in adults with AD treated with dupilumab (N = 20), AD patie...
Species differences influencing the safety assessment of CD3 T-cell engagers [0.03%]
影响CD3 T细胞衔接剂安全评估的物种差异
Taylor L Hickman,David A Gallegos,Shihui Zhong et al.
Taylor L Hickman et al.
Bispecific CD3 T-cell engagers (TCE) redirect endogenous T-cells to tumor cells and have demonstrated substantial clinical activity, but their mechanism of action also drives immune-mediated toxicities that are often underpredicted in nonhu...
Molecular sensitization patterns in atopic dermatitis: linking food and airborne allergens using ISAC [0.03%]
特应性皮炎的分子敏化模式：使用ISAC连接食物和吸入过敏原
Čelakovská J,Bukač J,Krejsek J et al.
Čelakovská J et al.
Objective: The aim of our study is to evaluate the laboratory results of sensitization to molecular components in atopic dermatitis patients and to show if there is the significant relation between the sensitization to mo...
Predicting cross reactivity between the fire ant venom allergen Sol i 3 and the antigen 5 from vespid venoms based on molecular modeling computing [0.03%]
基于分子建模计算预测火蚁毒液过敏原Sol i 3与黄蜂毒液中的抗原5之间的交叉反应性
Amilcar Perez-Riverol,Luis Gustavo Romani Fernandes,José Roberto Aparecido Dos Santos-Pinto et al.
Amilcar Perez-Riverol et al.
The fire ant Solenopsis invicta is an aggressive invasive species whose venom frequently triggers hypersensitivity reactions, including severe anaphylaxis. In endemic regions, its stings represent a significant cause of Hymenoptera-related ...
Imazalil at high plasma concentrations: implications for neutrophil immunophenotype [0.03%]
高血浆浓度的 Imazalil 对中性粒细胞免疫表型的影响
Wioletta Ratajczak-Wrona,Malgorzata Rusak,Olga Diana Drezek et al.
Wioletta Ratajczak-Wrona et al.
Neutrophil functions are tightly regulated by numerous membrane receptors, the activation of which determines the appropriate response to various endogenous and exogenous factors. Accumulating evidence indicates that environmental endocrine...
Micro- and nanoplastics-mediated immunometabolic reprogramming: a systemic nexus for chronic inflammation and multi-organ disease risk [0.03%]
微纳米塑料介导的免疫代谢重编程：慢性炎症和多器官疾病风险的系统纽带
Jingxuan Dai,Kun Yuan,Keming Huang et al.
Jingxuan Dai et al.
Micro- and nanoplastics (MNP) are ubiquitous environmental stressors increasingly detected in human tissues and directly linked to clinical cardiovascular events. This review proposes immunometabolic reprogramming as the central nexus throu...
Lung microbiota dysbiosis mediates PM2.5-induced pulmonary inflammation through antibiotic-reversible mechanisms [0.03%]
抗生素可逆机制介导的PM2.5引起的肺微生物群紊乱与肺部炎症反应关系的研究
Yongfei Zheng,Lin Zhang,Jiaqi Tian et al.
Yongfei Zheng et al.
Fine particulate matter (PM2.5) exposure contributes to over 4 million premature deaths annually, yet the mechanistic role of lung microbiota in PM2.5-induced pulmonary inflammation remains poorly understood. In collaboration of 16S rRNA an...
Evaluating miRNAs as predictive biomarkers for drug-induced autoimmune toxicity in D-penicillamine induced autoimmune diseases animal model [0.03%]
miRNA作为药物诱导自身免疫毒性预测性生物标志物的评估-D-青霉胺诱导自身免疫病动物模型研究
Ren Yuke,Qu Zhe,Zhang Di et al.
Ren Yuke et al.
Drug-induced autoimmune (DIA) toxicity represents a significant challenge in drug safety evaluation, and traditional autoantibody biomarker antinuclear antibodies (ANA) exhibits limitations in DIA assessment, highlighting the urgent need fo...
Associations between patient risk factors, disease severity, and inflammatory markers in community-acquired pneumonia [0.03%]
社区获得性肺炎患者危险因素、病情严重程度与炎症标志物之间的关联分析
Ruta Nutautiene,Irmantas Aleksa,Ieva Janulaityte et al.
Ruta Nutautiene et al.
Community-acquired pneumonia (CAP) remains a major cause of morbidity and mortality, particularly in older adults and patients with chronic co-morbidities. Cytokine patterns and simple hematological indices may improve risk stratification b...
Robert V House,Marc J Pallardy
Robert V House