Expression and clinical significance of the m6A reader YTHDF2 in peripheral blood mononuclear cells from rheumatoid arthritis patients [0.03%]
YTHDF2在类风湿关节炎患者外周血单个核细胞中的表达及临床意义
Fangyi Yao,Chuxin Xu,Yujie Gao et al.
Fangyi Yao et al.
As an important m6A reader, the YT521-B homology domain family 2 (YTHDF2) has been shown to regulate mRNA degradation and translation, and to be involved in inflammation. However, little is known about the role of YTHDF2 in the autoimmune-b...
Linda Allais,Alicia Perbet,Fabienne Condevaux et al.
Linda Allais et al.
Although an extrapolation from the clinical experience in adults can often be considered to support the pediatric use for most pharmaceutical compounds, differences in safety profiles between adult and pediatric patients can be observed. Th...
A T-cell-dependent antibody response (TDAR) method in BALB/c mice based on a cytometric bead array [0.03%]
基于流式细胞术微球阵列技术的BALB/c小鼠T细胞依赖性体液免疫响应检测方法
Wenhua Zhong,Penghuan Chang,Lianfang Gan et al.
Wenhua Zhong et al.
Most current methods to assess T-cell-dependent antibody responses (TDAR) are semi-quantitative and based on measures of antibody titer generated against a standard antigen like keyhole limpet hemocyanin (KLH). The precision, sensitivity, a...
Proteolytic activity accelerates the TH17/TH22 recall response to an epicutaneous protein allergen-induced TH2 response [0.03%]
蛋白酶活性加速表皮蛋白质变应原诱导的TH2反应后的TH17/TH22回忆反应
Akira Ogasawara,Takuo Yuki,Asuka Katagiri et al.
Akira Ogasawara et al.
Epicutaneous exposure to protein allergens, such as papain, house dust mite (HDM), and ovalbumin (OVA), represents an important mode of sensitization for skin diseases including protein contact dermatitis, immunologic contact urticaria, and...
Gallic acid attenuates cerebral ischemia/re-perfusion-induced blood-brain barrier injury by modifying polarization of microglia [0.03%]
没食子酸通过调节小胶质细胞极化减轻脑缺血再灌注引起的血脑屏障损伤
Yang Qu,Lin Wang,Yanfang Mao
Yang Qu
Microglia, the main immune effector cells in the central nervous system, play a dual role in the function/structure of the blood-brain barrier (BBB) and brain health. During and soon after a cerebral ischemic injury, microglia produce neuro...
Surgical stress quickly affects the numbers of circulating B-cells and neutrophils in murine septic and aseptic models through a β2 adrenergic receptor [0.03%]
外科手术压力通过β2肾上腺素受体快速影响败血症和无菌模型小鼠循环B细胞和中性粒细胞数量
Ryutaro Nishioka,Yusuke Nishi,Mohammed E Choudhury et al.
Ryutaro Nishioka et al.
Sepsis is a pathology accompanied by increases in myeloid cells and decreases in lymphoid cells in circulation. In a murine sepsis model induced by cecum ligation and puncture (CLP), increasing numbers of neutrophils and decreasing levels o...
Adaptation of an ELISA assay for detection of IgG2a responses against therapeutic monoclonal antibodies in a mouse immunization model [0.03%]
一种用于检测小鼠免疫模型中针对治疗性单克隆抗体的IgG2a应答的ELISA测定方法的改良
Shraddha S Rane,Rebecca J Dearman,Ian Kimber et al.
Shraddha S Rane et al.
Biotherapeutic monoclonal antibodies (mAb) play important roles in clinical medicine but their potential to elicit immune responses in patients remains a major issue. In a study designed to investigate the effect of aggregation on immunogen...
Renal tubular cell necroptosis: A novel mechanism of kidney damage in trichloroethylene hypersensitivity syndrome mice [0.03%]
三氯乙烯超敏感综合征肾损伤的新机制：肾小管细胞坏死
Yican Wang,Meng Huang,Xin Du et al.
Yican Wang et al.
Trichloroethylene (TCE) hypersensitivity syndrome (THS), called occupational medicamentosa-like dermatitis due to TCE (OMDT) in China, is a fatal occupational disorder caused by TCE exposure. Visceral damage, including kidney injury, is one...
Impact of injection buffer volume to perform bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion [0.03%]
注射缓冲液体积对支气管肺泡灌洗液采集的影响，以分离肺泡巨噬细胞来研究细颗粒物诱导的IL-1α分泌
Eita Sasaki,Haruka Momose,Keiko Furuhata et al.
Eita Sasaki et al.
The importance of alveolar macrophages has been reported in many toxicology/immunology studies. Alveolar macrophages release interleukin (IL)-1α as a damage-associated molecular pattern (DAMP) when stimulated by fine particles. However, it...
Application of a newly-developed cynomolgus macaque BiTE-mediated cytotoxic T-lymphocyte activity assay to various immunomodulatory agents in vitro [0.03%]
新开发的恒河猴BiTE介导的细胞毒性T淋巴细胞活性测定法在体外对各种免疫调节剂的应用
Brendon Frank,Hao Guo,Hervé Lebrec et al.
Brendon Frank et al.
The immunotoxic potential of drug candidates is assessed through the examination of results from a variety of in vitro and in vivo immunophenotyping and functional study endpoints in pre-clinical studies. CD8+ cytotoxic T-lymphocyte (CTL) a...