Effect of epithelial-specific MyD88 signaling pathway on airway inflammatory response to organic dust exposure [0.03%]
上皮细胞特异性MyD88信号通路对有机尘暴露所致气道炎症反应的影响
Amber N Johnson,John Dickinson,Amy Nelson et al.
Amber N Johnson et al.
The Toll-like receptor (TLR) adaptor protein MyD88 is integral to airway inflammatory response to microbial-enriched organic dust extract (ODE) exposures. ODE-induced airway neutrophil influx and release of pro-inflammatory cytokines was es...
Exposure to the anti-microbial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis [0.03%]
抗菌化学物质三氯生的暴露扰乱了人类表皮重建模型中的角质细胞功能和皮肤完整性
Rachel Baur,Michael Kashon,Ewa Lukomska et al.
Rachel Baur et al.
Triclosan is an anti-microbial chemical incorporated into products that are applied to the skin of healthcare workers. Exposure to triclosan has previously been shown to be associated with allergic disease in humans and impact the immune re...
Environmentally weathered polystyrene particles induce phenotypical and functional maturation of human monocyte-derived dendritic cells [0.03%]
环境风化的聚苯乙烯颗粒会引起人单核来源树突细胞的表型和功能成熟
Annemijne E T van den Berg,Maud Plantinga,Dick Vethaak et al.
Annemijne E T van den Berg et al.
Micro- and nanoplastics (MNP) are ubiquitously present in the environment due to their high persistence and bioaccumulative properties. Humans get exposed to MNP via various routes and consequently, they will encounter dendritic cells (DC) ...
Dolutegravir potentiates platelet activation by a calcium-dependent, ionophore-like mechanism [0.03%]
多拉替格拉夫通过钙依赖的促离子通道样机制增强血小板活化能力
Morris Madzime,Annette J Theron,Ronald Anderson et al.
Morris Madzime et al.
Dolutegravir is a highly potent HIV integrase strand transfer inhibitor that is recommended for first-line anti-retroviral treatment in all major treatment guidelines. A recent study has shown that people taking this class of anti-retrovira...
Strategies to evaluate potential effector function of glycan variants: a case study of ordesekimab (AMG 714 or PRV-015) [0.03%]
评估糖类变体潜在效应功能的策略：奥德司奇玛珠单抗（安进714或PRV-015）案例研究
Yu-Ling Wei,Teresa Wegesser,Scott Kuhns et al.
Yu-Ling Wei et al.
The potential for effector functions of therapeutic antibodies, including antibody-dependent cell-mediated cytotoxicity (ADCC), is a biological activity of interest for characterization, regardless of if ADCC is an intended primary pharmaco...
Ian Kimber,Nicole Woeffen,Kevin Sondenheimer
Ian Kimber
There is a continuing interest in whether Bisphenol A (BPA) is able to cause adverse health effects through interaction with elements of the immune system. That interest has been fuelled further by the recent publication of a draft opinion ...
ROS-mediated inflammatory response in liver damage via regulating the Nrf2/HO-1/NLRP3 pathway in mice with trichloroethylene hypersensitivity syndrome [0.03%]
ROS介导的Nrf2/HO-1/NLRP3信号通路调节的三氯乙烯超敏小鼠肝炎性反应
Feng Wang,Yiting Hong,Wei Jiang et al.
Feng Wang et al.
Trichloroethylene hypersensitivity syndrome (THS), mainly caused by occupational exposure to trichloroethylene (TCE), can give rise to serious and fatal hepatic damage. To date, the precise mechanisms of hepatic damage in THS remain unclear...
Mitochondrial disruption in isolated human monocytes: an underlying mechanism for cadmium-induced immunotoxicity [0.03%]
镉致免疫毒性的线粒体机制研究——人单核细胞的分离及培养检测方法研究报告
Ulfat M Omar,Ekramy M Elmorsy,Ayat B Al-Ghafari
Ulfat M Omar
Cadmium (Cd) is an immunotoxic metal frequently found in the environment. The in vitro study undertaken here evaluated the immunotoxic effects of Cd in isolated human peripheral blood monocytes (hPBM). The results of the studies of exposure...
Long non-coding RNA PMS2L2 is down-regulated in osteoarthritis and inhibits chondrocyte proliferation by up-regulating miR-34a [0.03%]
长链非编码RNA PMS2L2在骨关节炎中下调并通过上调miR-34a抑制软骨细胞增殖
Fei Yang,Min Zhao,Qinghua Sang et al.
Fei Yang et al.
Long non-coding RNA (lncRNA) PMS2L2 has been reported to participate in endotoxin-induced inflammatory responses. As these types of responses can promote osteoarthritis (OA), it was of interest to ascertain if PMS2L2 may be involved in OA. ...
Examining the role of nickel and NiTi nanoparticles promoting inflammation and angiogenesis [0.03%]
镍和NiTi纳米颗粒在促进炎症和血管生成中的作用研究
Anup K Srivastava,Dustin M Snapper,Jiwen Zheng et al.
Anup K Srivastava et al.
Nickel titanium (NiTi, or Nitinol) alloy is used in several biomedical applications, including cardiac, peripheral vascular, and fallopian tube stents. There are significant biocompatibility issues of metallic implants to nickel ions and na...