Fine tuning of the innate and adaptive immune responses by Interleukin-2 [0.03%]
白细胞介素-2对先天性和适应性免疫反应的精细调节
Christina Sakellariou,Luise A Roser,Susanne Schiffmann et al.
Christina Sakellariou et al.
Novel immunotherapies for cancer and other diseases aim to trigger the immune system to produce durable responses, while overcoming the immunosuppression that may contribute to disease severity, and in parallel considering immunosafety aspe...
Identification and semi-quantification of protein allergens in complex mixtures using proteomic and AllerCatPro 2.0 bioinformatic analyses: a proof-of-concept investigation [0.03%]
利用蛋白质组学和AllerCatPro 2.0生物信息学分析识别和半定量复杂混合物中的蛋白变应原：概念验证研究
Nora L Krutz,Ian Kimber,Jason Winget et al.
Nora L Krutz et al.
The demand for botanicals and natural substances in consumer products has increased in recent years. These substances usually contain proteins and these, in turn, can pose a risk for immunoglobulin E (IgE)-mediated sensitization and allergy...
Investigation into changes in inflammatory and immune cell markers in pre-diabetic patients from Durban, South Africa [0.03%]
南非德班地区糖尿病前期患者炎症和免疫细胞标志物变化调查研究
Nomusa Christina Mzimela,Aubrey Mbulelo Sosibo,Phikelelani Siphosethu Ngubane et al.
Nomusa Christina Mzimela et al.
The prevalence of pre-diabetes is increasing in rapidly urbanizing cities, especially in individuals aged 25 - 45 years old. Studies also indicate that this condition is associated with aberrant immune responses that are also influenced by ...
Vitamin D/Vitamin D receptor mitigates cisplatin-induced acute kidney injury by down-regulating C5aR [0.03%]
维生素D/维生素D受体通过下调C5a受体缓解顺铂所致急性肾损伤
Zhouyu Wen,Can Sun,Yan Lou et al.
Zhouyu Wen et al.
Cisplatin (DDP) is a potent chemotherapeutic; however, it can also cause acute kidney injury (AKI). Because of the complexity of the toxicity it induces, few effective methods exist for ameliorating any form of DDP-induced AKI. Recent resea...
Yin Yang 1 impacts upon preeclampsia by regulating Treg/TH17 cells and PI3K/AKT pathway [0.03%]
阴阳1通过调节Treg/TH17细胞和PI3K/AKT通路影响子痫前期的作用机制研究
Haowen Li,Ling Yu,Yiling Ding et al.
Haowen Li et al.
Preeclampsia (PE) is a common obstetric syndrome with an unclear etiology and pathogenesis. The study here aimed to investigate the role of Yin Yang 1 (YY1) in PE, and to reveal any YY1-regulated mechanisms in PE. Peripheral blood, placenta...
Endoplasmic reticulum stress mediates environmental particle-induced inflammatory response in bronchial epithelium [0.03%]
肺泡上皮细胞内环境应激介导的炎症反应
Li Pu,Fen Yi,Wen-Jing Yu et al.
Li Pu et al.
While the detailed mechanisms for how particulate matter (PM) causes adverse health effects in the lungs remain largely unknown, endoplasmic reticulum (ER) stress has been implicated in PM-induced lung injury. The present study was undertak...
Hsa_circ_0044235 and hsa_circ_0001947 as novel biomarkers in plasma of patients with new-onset systemic lupus erythematosus [0.03%]
新型自身免疫性标志物环状RNA在系统性红斑狼疮患者血浆中的表达研究
Qing Luo,Yutao Ye,Lu Zhang et al.
Qing Luo et al.
Circular RNA (circRNA) are novel types of non-coding RNA that may be used as non-invasive noninvasive biomarkers in clinical plasma samples. However, the role of circRNA in plasma samples from patients with new-onset systemic lupus erythema...
Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst [0.03%]
legacy and emerging per-和polyfluoroalkyl substances抑制 neutrophil respiratory burst
Drake W Phelps,Anika I Palekar,Haleigh E Conley et al.
Drake W Phelps et al.
Per- and polyfluoroalkyl substances (PFASs) are used in a multitude of processes and products, including nonstick coatings, food wrappers, and fire-fighting foams. These chemicals are environmentally-persistent, ubiquitous, and can be detec...
Current approaches to evaluate the function of cytotoxic T-cells in non-human primates [0.03%]
评估细胞毒性T细胞在非人灵长类动物功能的当前方法
Cris Kamperschroer,Brendon Frank,Caroline Genell et al.
Cris Kamperschroer et al.
Cytotoxic T-lymphocytes (CTL) are a subset of T-cells that play a critical role in protecting against intracellular infections and cancer, and have the ability to identify and kill infected or transformed cells expressing non-self peptides ...
Maritza Roxana Garcia Garcia,Noelia Casares,Luz Andrea Martinez Perez et al.
Maritza Roxana Garcia Garcia et al.
Immunogenic cell death (ICD) is a form of cell death characterized by the release of danger signals required to trigger an adaptive immune response against tumor-associated antigens. Silver nanoparticles (AgNP) display anti-proliferative an...