Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy [0.03%]
镍掺杂磁铁矿纳米颗粒的免疫原性质及其对癌症免疫治疗的意义
Lenka Rajsiglova,Michal Babic,Katerina Krausova et al.
Lenka Rajsiglova et al.
Nanoparticles are commonly used in diagnostics and therapy. They are also increasingly being implemented in cancer immunotherapy because of their ability to deliver drugs and modulate the immune system. However, the effect of nanoparticles ...
Codon optimized influenza H1 HA sequence but not CTLA-4 targeting of HA antigen to enhance the efficacy of DNA vaccines in an animal model [0.03%]
优化的流感H1HA密码子序列而不是CTLA-4将HA抗原靶向于增强动物模型中DNA疫苗的效力
Dito Anurogo,Chia-Yuan Chen,Chu-Chi Lin et al.
Dito Anurogo et al.
Infections caused by the influenza virus lead to both epidemic and pandemic outbreaks in humans and animals. Owing to their rapid production, safety, and stability, DNA vaccines represent a promising avenue for eliciting immunity and thwart...
Alar Aints,Marina Šunina,Raivo Uibo
Alar Aints
Molecular mimicry has been proposed to be a possible mechanism of induction of autoimmunity. In some cases, it is believed that such events could lead to a disease such as Type 1 diabetes (T1D). One of the primary MHC-I epitopes in the non-...
Systemic and immunotoxicity induced by topical application of perfluoroheptane sulfonic acid (PFHpS) or perfluorooctane sulfonic acid (PFOS) in a murine model [0.03%]
全氟庚烷磺酸和全氟辛烷磺酸对小鼠的毒理学作用研究
Lisa M Weatherly,Hillary L Shane,Laurel G Jackson et al.
Lisa M Weatherly et al.
Per- and polyfluoroalkyl substances (PFAS) are a large group of synthetic surfactants of over 12,000 compounds that are incorporated into numerous products for their chemical and physical properties. Studies have associated PFAS with advers...
Binary and quaternary mixtures of perfluoroalkyl substances (PFAS) differentially affect the immune response to influenza A virus infection [0.03%]
全氟烷基物质(PFAS)的二元和四元混合物对流感A病毒感染免疫反应的影响不同
Christina M Post,Carrie McDonough,B Paige Lawrence
Christina M Post
Per- and polyfluoroalkyl substances (PFAS) are anthropogenic organofluorine compounds that persist indefinitely in the environment and bioaccumulate throughout all trophic levels. Biomonitoring efforts have detected multiple PFAS in the ser...
Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps [0.03%]
全氟和多氟烷基物质改变先天性免疫功能：证据与数据空白
Drake W Phelps,Ashley M Connors,Giuliano Ferrero et al.
Drake W Phelps et al.
Per- and polyfluoroalkyl substances (PFASs) are a large class of compounds used in a variety of processes and consumer products. Their unique chemical properties make them ubiquitous and persistent environmental contaminants while also maki...
Pro-inflammatory interactions of streptolysin O toxin with human neutrophils in vitro [0.03%]
链球菌溶血素O毒素与人体中性粒细胞的促炎相互作用体外实验
D Joseph,A J Theron,C Feldman et al.
D Joseph et al.
The recent global resurgence of severe infections caused by the Group A streptococcus (GAS) pathogen, Streptococcus pyogenes, has focused attention on this microbial pathogen, which produces an array of virulence factors, such as the pore-f...
Correction [0.03%]
改正通知书
Published Erratum
Journal of immunotoxicology. 2024 Dec;21(1):2342736. DOI:10.1080/1547691X.2024.2342736 2024
IL-2-mediated hepatotoxicity: knowledge gap identification based on the irAOP concept [0.03%]
基于irAOP概念的对IL-2介导肝毒性的认知差距分析
Luise A Roser,Christina Sakellariou,Malin Lindstedt et al.
Luise A Roser et al.
Drug-induced hepatotoxicity constitutes a major reason for non-approval and post-marketing withdrawal of pharmaceuticals. In many cases, preclinical models lack predictive capacity for hepatic damage in humans. A vital concern is the integr...
Lung-delivered IL-10 therapy elicits beneficial effects via immune modulation in organic dust exposure-induced lung inflammation [0.03%]
经肺递送的IL-10免疫调节治疗可减轻有机粉尘暴露诱导的小鼠急性肺部炎症反应
Aaron D Schwab,Todd A Wyatt,Amy J Nelson et al.
Aaron D Schwab et al.
Efficacious therapeutic options capable of resolving inflammatory lung disease associated with environmental and occupational exposures are lacking. This study sought to determine the preclinical therapeutic potential of lung-delivered reco...