Anti-microbial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase [0.03%]
阳离子抗菌剂CPC通过抑制Syk酪氨酸磷酸化抑制肥大细胞功能
Bright Obeng,Lucas J Bennett,Bailey E West et al.
Bright Obeng et al.
Cetylpyridinium chloride (CPC) is a quaternary ammonium antimicrobial used in numerous personal care products, human food, cosmetic products, and cleaning solutions. Yet, there is minimal published data on CPC effects on eukaryotes, immune ...
Novel strategies to assess cytokine release mediated by chimeric antigen receptor T cells based on the adverse outcome pathway concept [0.03%]
基于不良结局途径概念评估嵌合抗原受体T细胞介导的细胞因子释放的新策略
Miriam Alb,Kristin Reiche,Michael Rade et al.
Miriam Alb et al.
The success of cellular immunotherapies such as chimeric antigen receptor (CAR) T cell therapy has led to their implementation as a revolutionary treatment option for cancer patients. However, the safe translation of such novel immunotherap...
Using irAOP for non-clinical safety evaluation of biotechnology-derived pharmaceuticals and ATMPs: a paradigm shift into a systematic and holistic framework [0.03%]
用于生物技术药物和先进治疗产品的非临床安全评价的IR-AOP：系统化及整体化框架下的范式转变
Armin Braun,Susann Dehmel
Armin Braun
The chances and opportunities in modern biology inspired devising new therapeutics are mind blowing. The promises reach from successfully treating so-far incurable diseases like cancer and certain infections, to modulating and fine tuning t...
Revival of recombinant IL-2 therapy - approaches from the past until today [0.03%]
重组IL-2疗法的复兴——从过去到现在的方法
Luise A Roser,Charline Sommer,Samira Ortega Iannazzo et al.
Luise A Roser et al.
Interleukin-2 (IL-2) was one of the first cytokines discovered and its central role in T cell function soon led to the notion that the cytokine could specifically activate immune cells to combat cancer cells. Recombinant human IL-2 (recIL-2...
Type 2 responses determine skin rash during recombinant interleukin-2 therapy [0.03%]
第二型反应决定重组白介素-2治疗中的皮肤症状
Charline Sommer,Vanessa Neuhaus,Patricia Gogesch et al.
Charline Sommer et al.
The skin is the organ most often affected by adverse drug reactions. Although these cutaneous adverse drug reactions (CADRs) often are mild, they represent a major burden for patients. One of the drugs inducing CADRs is aldesleukin, a recom...
An overview of immune safety avatar: mimicking the effects of immunomodulatory therapies on the immune system [0.03%]
免疫安全卫士概览：模拟免疫调节疗法对免疫系统的影响
Vanessa Neuhaus,Laure-Alix Clerbaux,Katherina Sewald
Vanessa Neuhaus
Innovative therapeutics like biologicals that modulate the immune system are on the rise. However, their immune-modulating characteristics can also lead sometimes to the induction of adverse effects, by triggering unintended immune reaction...
Analyzing IL-2-induced vascular leakage with an irAOP as tool [0.03%]
用红外光声成像技术分析白细胞介素-2引起的血管通透性增加现象
Patricia Gogesch,Samira Ortega Iannazzo,Tamara Zimmermann et al.
Patricia Gogesch et al.
Immune-related adverse outcome pathways (irAOPs) are a toxicological tool for the structuring of complex immunological mechanisms. The EU-funded IMI-project imSAVAR analyses the applicability of irAOPs in pre-clinical safety assessment of i...
Identifying CD19-targeted CAR-T cell immune pathways in an in vitro human immune mimetic cytokine release assay [0.03%]
一种体外人免疫模拟细胞因子释放测定法可鉴定CD19靶向CAR-T细胞的免疫途径
Thuvan Dinh-Le,John Escobar,Louis Poisson et al.
Thuvan Dinh-Le et al.
CD19-targeted chimeric antigen receptor-modified T (CAR-T) cells have shown success in clinical studies, with several CD19 CAR-T cell products now having been approved for market use. However, this cell therapy can be associated with side e...
Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways [0.03%]
利用互动平台编码、管理和探索免疫相关不良结局途径
Alexander Mazein,Muhammad Shoaib,Miriam Alb et al.
Alexander Mazein et al.
This work focuses on the need for modeling and predicting adverse outcomes in immunotoxicology to improve nonclinical assessments of the safety of immunomodulatory therapies. The integrated approach includes, first, the adverse outcome path...
Assessment of dermal sensitization by nickel salts in a novel humanized TLR-4 mouse model [0.03%]
镍盐致皮肤过敏的TLR-4人源化小鼠模型评价研究
K A Roach,S E Anderson,C Waggy et al.
K A Roach et al.
The fundamental goal of this study was to determine the potential utility of a novel humanized Toll-like receptor-4 (hTLR-4) mouse model for future in vivo studies of nickel allergy. First, mice of both sexes and hTLR-4 expression profiles ...