A four-week study on the toxicity of repeated intramuscular administration of plant-based BA-CoV2-0301 vaccine against SARS-CoV-2 in Sprague-Dawley rats [0.03%]
四种基于植物的BA-CoV2-0301新冠疫苗反复肌肉注射给Sprague Dawley大鼠后的四周期毒试验研究报告
Sang-Jin Park,Seonghyeon Kim,Eun-Young Gu et al.
Sang-Jin Park et al.
In December 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China, leading to the global Coronavirus Disease pandemic. The rapid spread of SARS-CoV-2 highlighted the urgent need for effe...
No relationship between non-IgE-mediated mechanisms (complement activation or direct activation of mast cells and basophils) during diclofenac etalhyaluronate (SI-613/ONO-5704)-induced anaphylaxis [0.03%]
非IgE介导的机制(补体激活或直接活化肥大细胞和嗜碱性粒细胞)与双氯芬酸乙基玻璃酸钠(SI-613 / ONO-5704)所致过敏性休克无关
Shuhei Takada,Dai Muramatsu,Yasuaki Isoda et al.
Shuhei Takada et al.
It was previously reported that half of the anaphylaxis cases occurring after intra-articular administration of diclofenac etalhyaluronate (DEH) - developed as SI-613/ONO-5704 and marketed as JOYCLU® - were induced by IgE-mediated mechanis...
Inflammatory markers in prostate cancer: potential roles in risk stratification and immune profiling [0.03%]
前列腺癌的炎症标志物：在风险分层和免疫谱分析中的潜在作用
Edgaras Burzinskis,Ieva Janulaityte,Mindaugas Jievaltas et al.
Edgaras Burzinskis et al.
Inflammation plays a critical role in prostate cancer (PCa) pathophysiology, yet the diagnostic value of specific inflammatory markers remains unclear. This study evaluates the association between circulating and tissue inflammatory markers...
Correction [0.03%]
改正错误
Published Erratum
Journal of immunotoxicology. 2025 Dec;22(1):2483130. DOI:10.1080/1547691X.2025.2483130 2025
Immunotoxicological disruption of pregnancy as a new research area in immunotoxicology [0.03%]
免疫毒理学新研究领域中妊娠的免疫毒理扰乱
Kazuichi Nakamura
Kazuichi Nakamura
Immune mechanisms associated with normal pregnancy have only been being substantively investigated since the early 1990s. In parallel with the progress in that area of research, in the past few years it has become increasingly clear that se...
Immunophenotypical characterization of immune checkpoint receptor expression in cynomolgus monkeys and human healthy volunteers in resting and in T-cell stimulatory conditions in vitro [0.03%]
体外静息和T细胞刺激条件下食蟹猴和健康人体内免疫检查点受体的免疫表型特征分析
Danielle Craig-Meyer,Joseph A Hollenbaugh,Sara Morgado et al.
Danielle Craig-Meyer et al.
Immunotherapeutics targeting immune checkpoint receptors or their ligands (i.e., immune checkpoint inhibitors), have been groundbreaking in the field of oncology, radically changing the approach to treatment and improving the clinical outco...
Effects of efgartigimod treatment on humoral and cellular immune responses: analysis of T-cell-dependent antibody response in cynomolgus monkeys [0.03%]
Efgartigimod治疗对体液和细胞免疫反应的影响：食蟹猴T细胞依赖性抗体应答分析
Ornella Binazon,Mario Cocco,Daniel Thwaites et al.
Ornella Binazon et al.
Efgartigimod is a human IgG1 antibody Fc fragment that reduces IgG levels through neonatal Fc receptor blockade. This study evaluated whether efgartigimod affects the generation of T-cell-dependent antibodies and cellular immune responses t...
Generation of cynomolgus monkey capsid-specific positive control cells for IFNγ ELISpot assays for adeno-associated gene therapy applications [0.03%]
一种用于腺相关基因治疗应用的IFNγ ELISpot检测的食蟹猴样本阳性对照细胞系的建立
Sandra Casinghino,Karrie Tartaro,Jessica Anderson et al.
Sandra Casinghino et al.
Cell-mediated immune (CMI) responses to adeno-associated virus (AAV) can lead to tissue damage and loss of therapeutic transgene expression. Identifying robust biomarkers and mechanisms of CMI can aid clinical practice and advancement of AA...
Anti-inflammatory effect of Plantago asiatica crude extract in rat gout arthritis model [0.03%]
萹蓄粗提液抗痛风镇痛作用的实验研究
Bingjun Qian,Jun Hu,Li Dai et al.
Bingjun Qian et al.
Plantago asiatica L., a perennial herb in the family Plantaginaceae, has been shown to impart several pharmacologic activities, including anti-oxidative, anti-inflammatory, and diuretic effects. In the study here, the anti-gout(y) arthritis...
Consideration of the EXiLE test for predicting anaphylaxis after diclofenac etalhyaluronate administration [0.03%]
EXiLE试验在预测玻璃酸钠(diclofenac eticalcium hydrate)注射后过敏反应中的应用考虑
Haruyo Akiyama,Chisato Kurisaka,Dai Muramatsu et al.
Haruyo Akiyama et al.
Diclofenac etalhyaluronate, an active pharmaceutical ingredient in JOYCLU® (JCL), serves as a joint function improvement agent in knee and hip osteoarthritis patients. However, frequent cases of anaphylaxis induced by JCL administration ha...