Hillary L Shane,Carrie M Long,Stacey E Anderson
Hillary L Shane
Chemical allergy can manifest into allergic contact dermatitis and asthma and the importance of skin sensitization in both of these diseases is increasingly being recognized. Given the unique characteristics of chemical allergy, coupled wit...
Transcriptome analysis of low-dose ionizing radiation-impacted genes in CD4+ T-cells undergoing activation and regulation of their expression of select cytokines [0.03%]
低剂量电离辐射影响活化CD4⁺T细胞转录组及调控特定细胞因子表达的分析
Seong-Jun Cho,Hana Kang,Eun-Hee Hong et al.
Seong-Jun Cho et al.
Immune cells are known as the most sensitive tissue for ionizing radiation. Numerous reports relating with the effect of low-dose ionizing radiation (LDIR) on immune activities showed that LDIR can induce immune-potentiation via modulating ...
Involvement of CCL2/CCR2 macrophage recruitment in amodiaquine-induced liver injury [0.03%]
抗疟药氨酚喹诱发肝损伤中的CCL2/C CR2巨噬细胞募集作用
Alastair Mak,Jack Uetrecht
Alastair Mak
Evidence suggests that macrophages may play a role in the development of idiosyncratic drug-induced liver injury (IDILI). However, there has yet to be a clear link between macrophage activation and the inflammatory infiltrate that is charac...
Oligoclonal selection of nanobodies targeting vascular endothelial growth factor [0.03%]
寡克隆选择针对血管内皮生长因子的纳米体
Mehrdad Ahadi,Haniyeh Ghasemian,Mahdi Behdani et al.
Mehrdad Ahadi et al.
While monoclonal antibodies are efficient therapeutics for cancer treatment, nanobodies or variable heavy domain - due to their small size, high stability, and solubility - have many advantages in comparison. Oligoclonal nanobodies are a mi...
Bradykinin receptor in immune-mediated renal tubular injury in trichloroethylene-sensitized mice: Impact on NF-κB signaling pathway [0.03%]
三氯乙烯致敏小鼠肾小管免疫损伤中缓激肽受体的作用及对NF-κB信号转导通路的影响
Ling Yang,Jiaxiang Zhang,Na Li et al.
Ling Yang et al.
Trichloroethylene (TCE) is known to induce skin disorders and multi-system dysfunction, but the mechanism of this multi-organ injury is not entirely clear. It was shown in a previous study that levels of pivotal end-products of the kallikre...
Assessment of the potential allergenicity of genetically-engineered food crops [0.03%]
转基因粮食作物潜在致敏性评估
Gregory S Ladics
Gregory S Ladics
An extensive safety assessment process exists for genetically-engineered (GE) crops. The assessment includes an evaluation of the introduced protein as well as the crop containing the protein with the goal of demonstrating the GE crop is "a...
The skin as a metabolic and immune-competent organ: Implications for drug-induced skin rash [0.03%]
具有代谢和免疫功能的皮肤：对药物诱发皮疹的影响
Amy Sharma,Yoshiro Saito,Shuen-Iu Hung et al.
Amy Sharma et al.
Current advances in the study of cutaneous adverse drug reactions can be attributed to the recent understanding that the skin is both a metabolically and immunologically competent organ. The ability of the skin to serve as a protective barr...
Development of a BiTE®-mediated CD8+ cytotoxic T-lymphocyte activity assay to assess immunomodulatory potential of drug candidates in Cynomolgus macaque [0.03%]
开发用于评估药物候选物在食蟹猴中免疫调节潜能的BiTE介导的CD8+细胞毒性T淋巴细胞活性测定法
Brendon Frank,Yu-Ling Wei,Kyung-Hoon Kim et al.
Brendon Frank et al.
The immunotoxic potential of drug candidates is assessed through the examination of results from a variety of studies and endpoints. While the functional assessment of CD8+ cytotoxic T-lymphocytes (CTL) is well-characterized in the clinic, ...
Methoxychlor metabolite HPTE alters viability and differentiation of embryonic thymocytes from C57BL/6 mice [0.03%]
除草剂methoxychlor代谢物HPTE改变C57BL/6小鼠胚胎胸腺细胞的存活率和分化情况
Lucie Leung-Gurung,Priscilla Escalante Cobb,Faraj Mourad et al.
Lucie Leung-Gurung et al.
Endocrine-disrupting chemicals (EDC) are widespread in the built and natural environments. Heightened public awareness of their potential danger has led to concern about whether EDC and their metabolites have significant negative biological...
Modulation of cytokine/chemokine production in human macrophages by bisphenol A: A comparison to analogues and interactions with genistein [0.03%]
双酚A对人类巨噬细胞中细胞因子/趋化因子产生的调节作用及其与类似物和大豆异黄酮的相互作用
Yingjia Chen,Hannah Shibo Xu,Tai L Guo
Yingjia Chen
The immunotoxicant bisphenol A (BPA) may produce toxic effects on organs and systems, in part, by altering the secretion of cytokines and chemokines. However, systematic studies of the effects of BPA, let alone of its analogs and in cases w...
Comparative Study
Journal of immunotoxicology. 2018 Dec;15(1):96-103. DOI:10.1080/1547691X.2018.1476629 2018