Di-(2-ethylhexyl)-phthalate interferes with T-follicular helper cell differentiation and cytokine secretion through signaling lymphocytic activation molecule family member-1 [0.03%]
邻苯二甲酸二丁酯通过淋巴细胞活化分子信号家族成员-1干扰滤泡辅助T细胞的分化和细胞因子分泌
Yu Han,Xiaoying Wang,Xiaoxiao Pang et al.
Yu Han et al.
Exposure to the widely-used phthalate plasticizer di-(2-ethylhexyl)-phthalate (DEHP) has been shown to be closely related to an increased prevalence of allergic diseases in infants and juveniles. Earlier work in our laboratory found that DE...
Improvement and optimization of a T-cell-dependent antibody response (TDAR) method for BALB/c mice using keyhole limpet hemocyanin (KLH) as specific antigen [0.03%]
利用铜螺杆菌作为特异性抗原改善和优化BALB/C小鼠T细胞依赖性抗体反应(TDAR)的方法
Penghuan Chang,Ling Huang,Mianqing Huang et al.
Penghuan Chang et al.
Although T-cell-dependent antibody response (TDAR) assays with keyhole limpet hemocyanin (KLH) as specific antigen have many advantages, most experiments produce qualitative results based on antibody titers. It was hypothesized that if expe...
Effects of quercetin on Aroclor 1254-induced expression of CYP450 and cytokines in pregnant rats [0.03%]
芦丁对Aroclor 1254诱导的大鼠孕鼠CYP450和细胞因子表达的影响
Lina Xu,Xiaojun Guo,Nan Li et al.
Lina Xu et al.
The present study aimed to investigate the protective effect of quercetin on polychlorinated biphenyls (PCB)-induced liver and embryo damage in pregnant Sprague-Dawley rats. Pregnant rats were divided into five groups, and then were orally ...
Silver nanoparticle immunomodulatory potential in absence of direct cytotoxicity in RAW 264.7 macrophages and MPRO 2.1 neutrophils [0.03%]
银纳米颗粒在RAW 264.7巨噬细胞和MPRO 2.1中性粒细胞中无直接细胞毒性的免疫调节潜能
Nasser B Alsaleh,Valerie C Minarchick,Ryan P Mendoza et al.
Nasser B Alsaleh et al.
Engineered nanomaterials (ENM) are being used in a wide range of consumer products and pharmaceuticals; hence, there is an increasing risk for human exposure and potential adverse outcomes. The immune system, vital in host defense and prote...
An ELISA for detection of complement-bound circulating immune complexes in mice [0.03%]
一种检测小鼠结合补体的循环免疫复合物的ELISA方法
Lykke Boysen,Brian Lauritzen,Birgitte Martine Viuff et al.
Lykke Boysen et al.
Measurements of complement-bound circulating immune complexes (cCICs) in pre-clinical studies may provide important information about the etiology of certain pathology findings suggestive of being immune complex mediated. This article descr...
Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease [0.03%]
金属纳米材料：物理化学性质对致敏、激发和加重过敏性疾病的影响及其免疫效应
Katherine A Roach,Aleksandr B Stefaniak,Jenny R Roberts
Katherine A Roach
The recent surge in incorporation of metallic and metal oxide nanomaterials into consumer products and their corresponding use in occupational settings have raised concerns over the potential for metals to induce size-specific adverse toxic...
In vitro human helper T-cell assay to screen antibody drug candidates for immunogenicity [0.03%]
体外人体辅助T细胞测定用于筛选抗体药物候选者的免疫原性
Shunsuke Ito,Tatsuya Ikuno,Masayuki Mishima et al.
Shunsuke Ito et al.
Monoclonal antibody (mAb) drugs offer a number of valuable treatments. Many newly developed mAb drugs include artificial modification of amino acid sequences from human origin, which may cause higher immunogenicity to induce anti-drug antib...
Topical minocycline foam 4%: Results of four phase 1 studies evaluating the potential for phototoxicity, photoallergy, sensitization, and cumulative irritation [0.03%]
4％米诺环素泡沫制剂：四项一期研究评估其潜在光毒性、光过敏性、致敏性和累积刺激性的结果
Jonathan Dosik,Herman Ellman,Iain Stuart
Jonathan Dosik
FMX101 4% contains 4% micronized minocycline (as an HCl) formulated in a lipophilic foam vehicle for topical administration. FMX101 4% has been shown to be an effective and well-tolerated treatment for moderate-to-severe acne in three Phase...
Detection and quantification of VEGFR-1 in the nuclei of tumor cells by a new flow cytometry-based method [0.03%]
一种新的基于流式细胞术的方法检测并量化肿瘤细胞核内的VEGFR-1蛋白
Ekaterina Tyrsina,Sergey Nikulitskiy,Andrey Inshakov et al.
Ekaterina Tyrsina et al.
Flow cytometry using fluorescent antibodies (FC) is the method of choice for the quantitation of proteins expressed at the surface or inside the cell, but, however, does not allow to selectively measure nuclear expression. We therefore soug...
Toxicity of silver nanoparticles in mouse bone marrow-derived dendritic cells: Implications for phenotype [0.03%]
银纳米颗粒对小鼠骨髓来源的树突状细胞毒性的影响及其意义
Sandra Castro-Gamboa,Maritza Roxana Garcia-Garcia,Gabriela Piñon-Zarate et al.
Sandra Castro-Gamboa et al.
Silver nanoparticles (AgNP) are one of the most studied nanoparticles due to their anti-bacterial, -fungal, -viral, -parasitic, and -inflammatory properties. This raises the need to evaluate the toxicity and biological effects of AgNP in th...