Immunostimulatory effects on THP-1 cells by peptide or protein pharmaceuticals associated with injection site reactions [0.03%]
与注射部位反应相关肽或蛋白质药物对THP-1细胞的免疫刺激作用
Eri Hamamura-Yasuno,Tetsuo Aida,Yoshimi Tsuchiya et al.
Eri Hamamura-Yasuno et al.
Injection site reaction (ISR) is a common side-effect associated with the use of peptide or protein pharmaceuticals. These types of pharmaceuticals-induced activation of antigen-presenting cells is assumed to be a key step in the pathogenes...
KMRC011, an agonist of toll-like receptor 5, mitigates irradiation-induced tissue damage and mortality in cynomolgus monkeys [0.03%]
TLR5激动剂KMRC001通过改善肠道菌群减少电离辐射损伤及提高食蟹猴存活率
Hong-Soo Lee,Doo-Wan Cho,Ji-Seok Han et al.
Hong-Soo Lee et al.
In the study here, the potential applicability of KMRC011 - an agonist of toll-like receptor-5 - as a countermeasure for radiation toxicities was evaluated. Following a single 5.5 Gy total body irradiation (TBI, surface absorbed dose = 7 Gy...
Activation of aryl hydrocarbon receptor (AhR) in mesenchymal stem cells modulates macrophage polarization in asthma [0.03%]
成纤维细胞活化蛋白在哮喘气道炎症中的作用及机制研究
Zhuang Cui,Yuan Feng,Danqing Li et al.
Zhuang Cui et al.
Macrophage polarization has been demonstrated to exert a vital role on asthma pathogenesis. Mesenchymal stem cells (MSC) have the capacity to modulate macrophage differentiation from a pro-inflammatory M1 phenotype toward an anti-inflammato...
Mucosal-associated invariant T-Cell (MAIT) activation is altered by chlorpyrifos- and glyphosate-treated commensal gut bacteria [0.03%]
肠道共生菌被氯 pyrifos 和 glyphosate 处理后改变粘膜相关不变t细胞（mait）的活化状态
Anne Mendler,Florian Geier,Sven-Bastiaan Haange et al.
Anne Mendler et al.
Mucosal-associated invariant T-cells (MAIT) can react to metabolites of the vitamins riboflavin and folate which are produced by the human gut microbiota. Since several studies showed that the pesticide chlorpyrifos (CPF) and glyphosate (GL...
Observational Study
Journal of immunotoxicology. 2020 Dec;17(1):10-20. DOI:10.1080/1547691X.2019.1706672 2020
Altered levels of complement components associated with non-immediate drug hypersensitivity reactions [0.03%]
与非即刻型药物过敏反应相关的补体成分水平变化
Feng Wang,Liping Huang,Junfeng Yu et al.
Feng Wang et al.
Nonimmediate drug hypersensitivity reactions (niDHRs) range from mild-type maculopapular exanthema (MPE) to severe type Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with unentirely clarified pathogenesis. This study s...
Exposure to low-dose arsenic in early life alters innate immune function in children [0.03%]
生命早期暴露于低剂量砷可改变儿童先天性免疫功能
Faruque Parvez,Evana Akhtar,Lamia Khan et al.
Faruque Parvez et al.
Early-life exposure to arsenic (As) increases risks of respiratory diseases/infections in children. However, data on the ability of the innate immune system to combat bacterial infections in the respiratory tracts of As-exposed children are...
Formation and glomerular deposition of immune complexes in mice administered bovine serum albumin: Evaluation of dose, frequency, and biomarkers [0.03%]
剂量、频率和生物标志物评价对注射牛血清白蛋白小鼠免疫复合物的形成及肾小球沉积的影响
Lykke Boysen,Birgitte M Viuff,Lone H Landsy et al.
Lykke Boysen et al.
In preclinical toxicity studies, species-foreign proteins administered to animals frequently leads to formation of anti-drug antibodies (ADA). Such antibodies may form circulating immune complexes (CIC) with the administered protein. These ...
Anastasiya Kalinina,Mariya Zamkova,Elena Antoshina et al.
Anastasiya Kalinina et al.
Cyclophilin A (CypA), an 18 kDa multi-functional protein with cis-trans isomerase activity, is both a ligand for cyclosporine A and a proinflammatory factor. CypA is also a chemoattractant for hemopoietic stem cells and progenitors of diffe...
Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells [0.03%]
低剂量毒杀芬通过选择性影响细胞毒性淋巴细胞诱导人类淋巴细胞增殖抑制、衰老和促炎症细胞因子产生
Martha Cecilia Téllez-Bañuelos,Salvador González-Ochoa,Pablo Cesar Ortiz-Lazareno et al.
Martha Cecilia Téllez-Bañuelos et al.
Endosulfan is a DDT-era organochlorine pesticide. Due to past and current environmental contamination, investigation of endosulfan exposure is of current importance. Acute high dose exposure precipitates neural/endocrine system damage, but ...
Utilization of lipopolysaccharide challenge in cynomolgus macaques to assess IL-10 receptor antagonism [0.03%]
应用脂多糖刺激食蟹猴以评估IL-10受体拮抗作用的效应
Cris Kamperschroer,Richard Goldstein,Patricia A Schneider et al.
Cris Kamperschroer et al.
The current era of drug discovery has been marked by a significant increase in the development of immune modulating agents to address a range of diseases such as cancer, chronic inflammation, and other conditions of dysregulated immunity. N...