Effect of lead exposure and nutritional iron-deficiency on immune response: A vaccine challenge study in rats [0.03%]
铅暴露和营养性缺铁对免疫反应的影响：大鼠疫苗攻毒研究
Srinivasa Reddy Yathapu,Narendra Babu Kondapalli,Sarath Babu Srivalliputturu et al.
Srinivasa Reddy Yathapu et al.
The prevalence of iron (Fe) deficiency and subclinical lead (Pb) toxicity is high in developing countries like India, and information on their potential additive effects on immune responses is scant. The current study assessed immune parame...
Prenatal arsenic exposure interferes in postnatal immunocompetence despite an absence of ongoing arsenic exposure [0.03%]
孕期砷暴露会干扰后代免疫 competence尽管在断奶后没有持续的砷暴露
Mainak Chakraborty,Moumita Bhaumik
Mainak Chakraborty
Arsenic (As) readily crosses the placenta and exposure of the fetus may cause adverse consequences later in life, including immunomodulation. In the current study, the question was asked how the immune repertoire might respond in postnatal ...
MRGPRX2 activation as a rapid, high-throughput mechanistic-based approach for detecting peptide-mediated human mast cell degranulation liabilities [0.03%]
一种快速的基于机制的高通量筛选方法用于检测肽介导的人肥大细胞脱颗粒作用缺陷
Marc A Lafleur,Jonathan Werner,Madeline Fort et al.
Marc A Lafleur et al.
Mast cells play key roles in allergy, anaphylaxis/anaphylactoid reactions, and defense against pathogens/toxins. These cells contain cytoplasmic granules with a wide spectrum of pleotropic mediators that are released upon activation. While ...
Potential classification of chemical immunologic response based on gene expression profiles [0.03%]
基于基因表达谱的化学免疫反应潜在分类方法研究
Stacey E Anderson,Rachel Baur,Michael Kashon et al.
Stacey E Anderson et al.
Occupational immune diseases are a serious public health burden and are often a result of exposure to low molecular weight (LMW) chemicals. The complete immunological mechanisms driving these responses are not fully understood which has mad...
In vivo assessment of respiratory burst inhibition by xenobiotic exposure using larval zebrafish [0.03%]
利用斑马鱼幼体检测外来物质暴露对呼吸爆发的抑制作用
Drake W Phelps,Ashley A Fletcher,Ivan Rodriguez-Nunez et al.
Drake W Phelps et al.
Currently, assessment of the potential immunotoxicity of a given agent involves a tiered approach for hazard identification and mechanistic studies, including observational studies, evaluation of immune function, and measurement of suscepti...
Circulating inflammatory markers in cervical cancer patients and healthy controls [0.03%]
宫颈癌患者和健康对照者循环炎症标志物的分析
Agne Vitkauskaite,Daiva Urboniene,Joana Celiesiute et al.
Agne Vitkauskaite et al.
There is increasing evidence that host inflammatory responses play an important role in the development and progression of cancers. There are some data that cancer is associated not only with inflammation at the site of the lesion, but also...
Observational Study
Journal of immunotoxicology. 2020 Dec;17(1):105-109. DOI:10.1080/1547691X.2020.1755397 2020
Environmental pollutants modulate RNA and DNA virus-activated miRNA-155 expression and innate immune system responses: Insights into new immunomodulative mechanisms [0.03%]
环境污染物调节RNA和DNA病毒激活的miRNA-155表达及固有免疫反应：关于新的免疫调控机制的新见解
Alexander Badry,Veerle L B Jaspers,Courtney A Waugh
Alexander Badry
Many persistent organic pollutants, such as polychlorinated biphenyls (PCBs), have high immunomodulating potentials. Exposure to them, in combination with virus infections, has been shown to aggravate outcomes of the infection, leading to i...
Mark Collinge,Patricia Schneider,Dingzhou Li et al.
Mark Collinge et al.
Nonclinical immunotoxicity evaluation is an important component of safety assessment for pharmaceuticals. One in vitro assay that can be applied in a weight of evidence assessment is the human lymphocyte activation (HuLA) assay, an antigen ...
Colostrum fails to prevent bovine/camelid neonatal neutrophil damage from AFB1 [0.03%]
初乳不能预防黄曲霉毒素对牛和骆驼科动物新生儿中性粒细胞的损伤
Sajad Najafi,Gholamreza Mohammadi,Mehrdad Mohri et al.
Sajad Najafi et al.
Exposure to environmental toxicants that affect the immune system and overall health of many mammals is mostly unavoidable. One of the more common substances is the mycotoxins, especially carcinogenic aflatoxin (AF)B1 which also causes immu...
Summary of a workshop on preclinical and translational safety assessment of CD3 bispecifics [0.03%]
关于CD3双特异性药物临床前及转化安全性评估研讨会摘要
Cris Kamperschroer,Jacintha Shenton,Hervé Lebrec et al.
Cris Kamperschroer et al.
Currently, there is a multitude of CD3 bispecifics with different molecular designs and binding properties in preclinical and clinical development for the treatment of liquid or solid tumors. The key safety concerns with CD3 bispecifics are...