Galangin ameliorates experimental autoimmune encephalomyelitis in mice via modulation of cellular immunity [0.03%]
染料木素通过调节细胞免疫缓解小鼠自身免疫性脑脊髓炎
Kok-Tong Tan,Shiming Li,Lauren Panny et al.
Kok-Tong Tan et al.
Multiple sclerosis (MS) causes neurologic disabilities that effect musculature, sensory systems, and vision. This is largely due to demyelination of nerve fibers caused by chronic inflammation. Corticosteroid treatments ameliorate symptoms ...
Immune activation by microbiome shapes the colon mucosa: Comparison between healthy rat mucosa under conventional and germ-free conditions [0.03%]
肠道菌群激活免疫影响结肠粘膜结构和功能：健康大鼠常规饲养与无菌条件下的比较研究
Fabián Čaja,Dmitry Stakheev,Oleksander Chernyavskiy et al.
Fabián Čaja et al.
Germ-free animals (GF) are those without a microbiome since birth. This particular biological model has become one of special interest with the growing evidence of importance of the microbiome in the life, development, adaptation, and immun...
Effect of inhaled anesthetic gases on immune status alterations in health care workers [0.03%]
吸入麻醉气体对医护人员免疫状态改变的影响
Ashraf Mahmoud Emara,Khaled Ali Alrasheedi,Salha Dihim Alrashidi et al.
Ashraf Mahmoud Emara et al.
The objective of this research was to evaluate consequences to the immune system of long-term exposure to waste anesthetic gases (WAG) by medical theater personnel. Two groups were recruited: (i) 60 healthy male controls; (ii) 120 medical p...
In vitro prediction of in vivo pseudo-allergenic response via MRGPRX2 [0.03%]
基于MRGPRX2的伪过敏体外评价模型构建及其应用研究
Linu M John,Charlotte M Dalsgaard,Claus B Jeppesen et al.
Linu M John et al.
In development of peptide therapeutics, rodents are commonly-used preclinical models when screening compounds for efficacy endpoints in the early stages of discovery projects. During the screening process, some peptides administered subcuta...
Local inflammatory marker production in Lithuanian patients with chronic rhinosinusitis with nasal polyps [0.03%]
慢性鼻窦炎伴鼻息肉立陶宛患者的局部炎症标志物产生
Justinas Vaitkus,Astra Vitkauskiene,Vilte Matuseviciute et al.
Justinas Vaitkus et al.
There are two clinical subtypes of chronic rhinosinusitis (CRS): chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP). The aim of the study here was to determine the levels of invasive i...
Immunotoxicity studies of trans-resveratrol in male B6C3F1/N mice [0.03%]
trans-白藜芦醇的免疫毒理学研究及其在雄性B6C3F1/N小鼠中的作用
Madelyn C Huang,Kimber L White Jr,Susan A Elmore et al.
Madelyn C Huang et al.
Resveratrol is a naturally occurring polyphenol that is being investigated to treat and prevent various diseases, both experimentally and in the clinic. Despite increased use and interest in resveratrol due to its immunomodulatory propertie...
A T-cell-dependent antibody response study using a murine surrogate anti-PD-1 monoclonal antibody as an alternative to a non-human primate model [0.03%]
使用鼠源抗PD-1单克隆抗体替代非人灵长类动物模型进行T细胞依赖性抗体反应研究
Lisa M Plitnick,Beth Hutchins,Sheri Dubey et al.
Lisa M Plitnick et al.
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint which may be engaged by cells in a tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®) is a potent and highly selec...
Cadmium induces CCL2 production in glioblastoma cells via activation of MAPK, PI3K, and PKC pathways [0.03%]
镉通过激活MAPK，PI3K和PKC途径诱导胶质母细胞瘤中的CCL2产生
Thitima Kasemsuk,Suttinee Phuagkhaopong,Ruedeemars Yubolphan et al.
Thitima Kasemsuk et al.
Cadmium (Cd) is accumulated in human astrocytes and induces the production of interleukin (IL)-6 and IL-8. Astrocytes are one of the major sources of chemokine C-C motif ligand 2 (CCL2; known as monocyte chemoattractant protein-1 [MCP-1]), ...
The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity [0.03%]
草甘膦及其除草剂对健康和免疫力的影响及毒性
Cindy Peillex,Martin Pelletier
Cindy Peillex
Glyphosate, or N-phosphomethyl(glycine), is an organophosphorus compound and a competitive inhibitor of the shikimate pathway that allows aromatic amino acid biosynthesis in plants and microorganisms. Its utilization in broad-spectrum herbi...
Organic dust-induced lung injury and repair: Bi-directional regulation by TNFα and IL-10 [0.03%]
有机尘埃所致肺损伤与修复：TNFα和IL-10的双向调节作用
T A Wyatt,M Nemecek,D Chandra et al.
T A Wyatt et al.
Exposure to organic dust increases chronic airway inflammatory disorders. Effective treatment strategies are lacking. It has been reported that hog barn dust extracts (HDE) induce TNFα through protein kinase C (PKC) activation and that lun...