Talc and human cancer: a systematic review of the experimental animal and mechanistic evidence [0.03%]
滑石粉与人类癌症：实验动物及机制证据的系统回顾
Robyn L Prueitt,Nicholas L Drury,Ross A Shore et al.
Robyn L Prueitt et al.
The potential carcinogenicity of talc has been evaluated in many studies in humans and experimental animals published in the scientific literature over the last several decades, with a number of these studies reporting no associations betwe...
Data derived extrapolation factors (DDEFs) for rat to human interspecies extrapolation for the HPPD inhibitor mesotrione [0.03%]
用于人种外推的基于数据导出的外推因子（DDEF），以代谢物磺草酮处置大鼠为例
Alison M Pecquet,Katy Bridgwood,David Cowie et al.
Alison M Pecquet et al.
In the risk assessment of agrochemicals, there has been a historical paucity of using data to refine the default adjustment factors, even though large datasets are available to support this. The current state of the science for addressing u...
Denali Boon,Julie E Goodman,Kyle J Colonna et al.
Denali Boon et al.
Over the past several decades, there have been many epidemiology studies on talc and cancer published in the scientific literature, and several reviews and meta-analyses of talc and respiratory, female reproductive, and stomach cancers, spe...
Comprehensive analysis of gastrointestinal side effects in COVID-19 patients undergoing combined pharmacological treatment with azithromycin and hydroxychloroquine: a systematic review and network meta-analysis [0.03%]
羟氯喹和阿奇霉素联合治疗的新型冠状病毒肺炎患者的胃肠副作用综合分析：系统评价与网络meta分析
Gabriella Pacheco,André Luis Fernandes Lopes,Ana Patrícia de Oliveira et al.
Gabriella Pacheco et al.
During the COVID-19 pandemic, several drugs were repositioned and combined to quickly find a way to mitigate the effects of the infection. However, the adverse effects of these combinations on the gastrointestinal tract are unknown. We aime...
Zebrafish and nematodes as whole organism models to measure developmental neurotoxicity [0.03%]
斑马鱼和线虫的发育神经毒性整体动物模型评价方法及其应用研究进展
Samantha Hughes,Ellen V S Hessel
Samantha Hughes
Despite the growing epidemiological evidence of an association between toxin exposure and developmental neurotoxicity (DNT), systematic testing of DNT is not mandatory in international regulations for admission of pharmaceuticals or industr...
Sandra I Sulsky,Tracy Greene,P Robinan Gentry
Sandra I Sulsky
To accurately characterize human health hazards, human, animal, and mechanistic data must be integrated and the relevance to the research question of all three lines of evidence must be considered. Mechanistic data are often critical to the...
Interventional probability of causation (IPoC) with epidemiological and partial mechanistic evidence: benzene vs. formaldehyde and acute myeloid leukemia (AML) [0.03%]
基于流行病学和部分机制证据的介入因果概率（IPoC）：苯与甲醛所致急性髓系白血病（AML）的风险评估
Louis A Cox Jr,William J Thompson,Kenneth A Mundt
Louis A Cox Jr
Introduction: Causal epidemiology for regulatory risk analysis seeks to evaluate how removing or reducing exposures would change disease occurrence rates. We define interventional probability of causation (IPoC) as the ch...
A prioritization strategy for functional alternatives to bisphenol A in food contact materials [0.03%]
食品接触材料中双酚A功能性替代物的优先策略研究进展
Annick D van den Brand,Ellen V S Hessel,Rinus Rijk et al.
Annick D van den Brand et al.
The use of bisphenol A (BPA), a substance of very high concern, is proposed to be banned in food contact materials (FCMs) in the European Union. To prevent regrettable substitution of BPA by alternatives with similar or unknown hazardous pr...
Gastrointestinal decontamination using oil-based solutions in patients with acute aluminum phosphide poisoning: a systematic review and meta-analysis [0.03%]
急性铝磷中毒患者使用基于油剂的溶液进行胃肠去污染的系统评价和meta分析
Amal S A F Hafez,Fatma M Elgazzar,Zahraa K Sobh et al.
Amal S A F Hafez et al.
Some studies suggested that gastrointestinal (GIT) decontamination with oil may improve the prognosis of patients who ingested aluminum phosphide (AlP). The aim of this study is to compare the efficacy and safety of gastric lavage with oil-...
A screening-level human health risk assessment of dietary intake of pesticide residues in produce as compared to consumer guide recommendations [0.03%]
基于消费者指南的农药膳食摄入暴露风险评估
Neva Jacobs,Daniel G Kougias,Fian Louie et al.
Neva Jacobs et al.
Consumers are confronted with conflicting information regarding the safety of specific foods. For example, the Environmental Working Group (EWG) publishes an annual consumer guide in which they rank the pesticide contamination of 46 popular...