Screening for the ovarian toxicity of industrial chemicals - ovarian follicles and corpora lutea counts in rats, an inter- and intra-laboratory comparison [0.03%]
工业化学品卵巢毒性的筛选-大鼠卵巢卵泡和黄体计数的实验室间和实验室内的对比研究
Olena Kucheryavenko,Karine Angeli,Vincent Bonnomet et al.
Olena Kucheryavenko et al.
The aim of this study was to identify the methodologies currently used by contract research organizations (CROs) for counting ovarian follicles and corpora lutea (CL) in the OECD Test Guideline (TG) 443 (Extended One-Generation Reproductive...
Evaluation of the modes of action for key noncancer effects of 1,3-Butadiene: input from an independent expert panel to support derivation of data-derived extrapolation factors [0.03%]
1,3-丁二烯关键非致癌效应作用模式的评估：为制定基于数据的推算因子提供独立专家小组的意见
Christopher R Kirman,John C Lipscomb,John Rogers et al.
Christopher R Kirman et al.
1,3-Butadiene (BD) is an important industrial chemical used in the production of plastics, rubbers, and polymers. This evaluation synthesizes mode of action (MOA) information to support interspecies extrapolations for key noncancer effects ...
The effect of antioxidants on antineoplastic-induced male reproductive system damage: a systematic review of experimental studies [0.03%]
抗氧化剂对化疗所致男性生殖系统损伤的影响：实验性研究的系统评价
Hale Bayram,Yaprak Dönmez Çakıl,Mustafa Erinç Sitar
Hale Bayram
Antineoplastic agents exacerbate oxidative stress and trigger inflammatory responses in the testis. Numerous studies have proposed antioxidants as a therapeutic approach to ameliorate chemotherapy-induced damage and improve reproductive out...
Weight-of-evidence assessment of the endocrine-disrupting properties of propylene oxide [0.03%]
丙烯氧化物具有内分泌干扰特性证据权重评估
Quan Shi,Erin Maloney,Satinder S Sarang et al.
Quan Shi et al.
Propylene oxide (PO) is a high-production-volume chemical widely used as an industrial intermediate and classified as carcinogen and mutagen in humans. Despite its regulatory significance, a comprehensive evaluation of its endocrine-disrupt...
The formaldehyde dispute - Part A: acute and chronic inhalation toxicity and the evolution of scientific knowledge [0.03%]
甲醛争议——急性吸入毒性和慢性吸入毒性以及科学认识的演变
Jacob Siracusa,Quincy Perry,Michael Stevens et al.
Jacob Siracusa et al.
Formaldehyde is a simple, highly reactive aldehyde whose inhalation toxicity has been characterized through more than five decades of human, animal, and mechanistic research. Across this literature, inhalation was illustrated to follow a co...
The formaldehyde dispute - Part B: scientific critique of EPA's formaldehyde occupational exposure values (OEVs) and proposed alternative occupational exposure limits (OELs) [0.03%]
甲醛之争——第二部分：美国环保署职业接触限值（OEV）的科学评论及建议替代职业接触限值（OEL）
Quincy Perry,Jacob Siracusa,Michael Stevens et al.
Quincy Perry et al.
In 2024, the U.S. Environmental Protection Agency (EPA) finalized its Integrated Risk Information System (IRIS) Toxicological Review and Toxic Substances Control Act (TSCA) Risk Evaluation for formaldehyde. After analyzing all the data that...
A framework for assessing the safety of degraded pharmaceuticals for long-duration space missions - Part 2: framework application in four case studies [0.03%]
长期太空任务中评估降解药物安全性的框架（第二部分）：四个案例研究的应用
Andrey Massarsky,Veneese J B Evans,Ernest S Fung et al.
Andrey Massarsky et al.
Spaceflight environmental conditions can alter the rate of degradation for some drug products; however, only a limited number of drugs have been tested after prolonged exposure to spaceflight. Existing ground-based drug stability studies do...
Response to Mr. DiNardo's "Letter to the Editor: Comprehensive review of octocrylene toxicology data and human exposure assessment for personal care products" [0.03%]
迪纳多先生《关于八异氰酸酯毒理学数据及个人护理产品中的人类接触评估的全面评论》来信答复
Kimberly G Norman,Lewis E Kaufman,Peter Griem et al.
Kimberly G Norman et al.
A framework for assessing the safety of degraded pharmaceuticals for long-duration space missions - Part 1: framework development [0.03%]
长期空间任务降解药物安全性评估框架——第一部分：开发评估框架
Andrey Massarsky,Veneese J B Evans,Ernest S Fung et al.
Andrey Massarsky et al.
The National Aeronautics and Space Administration (NASA) is planning exploration space missions to Mars, which will require plans for a wide array of medical contingencies, most of which require treatment with medications. A major challenge...