Critical review and implications of the results of the National Toxicology Program's carcinogenicity study of tris(chloropropyl)phosphate [0.03%]
美国国家毒理项目三(氯代丙基)磷酸酯致癌性研究结果的批判性评价及意义
Tracy Greene,Robinan Gentry
Tracy Greene
The National Toxicology Program (NTP) conducted a 2-year carcinogenicity study on male and female Harlan Sprague-Dawley rats and B6C3F1 mice, which were given tris(2-chloroisopropyl)phosphate (TCPP) in their diet at concentrations up to 10,...
Role of constitutive androstane receptor in developmental toxicology: linking chemical exposure, nutrition, and disease susceptibility [0.03%]
构成性安雄酮受体在发育毒理学中的作用：化学暴露、营养和疾病易感性的关联
Ryota Shizu,Kouichi Yoshinari
Ryota Shizu
The constitutive androstane receptor (CAR) is a xenobiotic-sensing nuclear receptor that regulates gene transcription involved in drug metabolism, especially in the liver. CAR activation influences detoxification pathways and disrupts endoc...
Genotoxic and epigenetic signatures of early-life pesticide exposure: a systematic review and meta-analysis [0.03%]
农药暴露的基因毒性和表观遗传特征：系统评价和Meta分析
Moustafa Sherif,Aya Darwish,Aya Samy et al.
Moustafa Sherif et al.
Prenatal and early childhood exposure to pesticides is a global concern, yet the genotoxic mechanisms potentially linking these exposures to adverse health outcomes remain incompletely characterized. We conducted a systematic review and ran...
Risk assessment of trace hydrazine in a 2020 bottled water-associated nonviral hepatitis outbreak [0.03%]
2020年瓶装水污染所致联胺 tracing 急性肝炎的风险评估
Blake M Deckard,Kylie M McCauley,Michael E Stevens et al.
Blake M Deckard et al.
Between August 1 and December 3, 2020, a 124-day outbreak of nonviral hepatitis occurred in geographically limited regions of Nevada and California, resulting in 21 hospitalized cases (18 in Nevada, 3 in California), including 18 intensive ...
Wildfires in the Pan-Amazon: what is known about health impacts on affected populations? [0.03%]
巴西亚马孙雨林大火对健康的影响研究进展及其知识空白
Elizeu Chiodi Pereira,Dayane da Fonseca Barbosa,Fernando Viana Rodovalho et al.
Elizeu Chiodi Pereira et al.
According to the World Health Organization, climate change is associated with detrimental health effects through air pollution, increased risk of infectious diseases, as well as extreme heat and drought. The rise in wildfires, exacerbated b...
Response to the Letter from Professor C. R. Wolf and colleagues concerning CRT, 55: 549-586, 2025: The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome-proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation [0.03%]
关于C.R. Wolf教授等人关于活化构成性安雄酮受体(CAR)和过氧化物酶增殖激活受体α(PPARα)的啮齿动物肝肿瘤形成的机制与人类致癌风险无关的评论的回复：最新评价
Tomoya Yamada,Samuel M Cohen,Brian G Lake
Tomoya Yamada
Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55( [0.03%]
致编辑的信：关于 Yamada T, Cohen SM, Lake BG. 的评论文章——构成性安雄酮受体(CAR)和过氧化物酶增殖激活受体α(PPARα)活化剂诱导啮齿类动物肝肿瘤形成的机制与人类致癌风险无关：更新的关键评估批判毒理学评论文章的回复
C Roland Wolf,Colin J Henderson,Michael Schwarz et al.
C Roland Wolf et al.
Comprehensive review of octocrylene toxicology data and human exposure assessment for personal care products [0.03%]
八氢松香醇毒理学数据及人体接触评估的全面回顾用于个人护理产品
Kimberly G Norman,Lewis E Kaufman,Peter Griem et al.
Kimberly G Norman et al.
A comprehensive review was conducted of existing toxicity and consumer exposure data for the ultraviolet (UV) filter octocrylene (2-ethylhexyl-2-cyano-3,3-diphenylacrylate) as currently used in over-the-counter sunscreen formulations. Octoc...
Response to letter to the editor on: "the use of canonical dose-response models for benchmark dose analysis of continuous toxicological data" [0.03%]
来信：“连续毒理学数据基准剂量分析的规范剂量反应模型应用”的答复
Wout Slob,Guangchao Chen,Martine I Bakker et al.
Wout Slob et al.
Letter to the Editor: Critical analysis of "The use of canonical dose-response models for benchmark dose analysis of continuous toxicological data" by Slob et al. (2025) [0.03%]
致编辑的信：对Slob等（2025）的“连续毒理学数据基准剂量分析中规范剂量反应模型的应用”的批判性分析
José Cortiñas Abrahantes,Efisio Solazzo,Marc Aerts et al.
José Cortiñas Abrahantes et al.