Microplastics-PFAS interactions in environmental matrices: quantitative evidence for antagonistic and synergistic toxicity [0.03%]
环境中微塑料与PFAS的相互作用：对抗和协同毒性的定量证据
Niyati Kuriyal,Abhishek Nandan
Niyati Kuriyal
Microplastics (MPs) and per- and polyfluoroalkyl substances (PFAS) increasingly co-occur across aquatic, terrestrial, and biological systems, yet their combined toxicological behavior remains poorly resolved. To address this gap, we conduct...
Setting occupational exposure limits (OELs) for carcinogens: a focus on benzene [0.03%]
致癌物职业接触限值的设定——以苯为例
Maria de Fatima M Pedrozo,Monica M B Paoliello
Maria de Fatima M Pedrozo
Since the 1950s, regulation of occupational carcinogen exposure has progressed from hazard identification to quantitative evaluation, driven by advances in cancer biology. This narrative review compares two approaches for setting Occupation...
Microplastic trafficking in maternal-fetal system: a systematic review and quantitative profiling linking particle characteristics to developmental biology [0.03%]
微塑料在母胎系统中的传输：结合颗粒特性与发育生物学的系统性回顾和量化分析
Syed Shabi Ul Hassan Kazmi,Syeda Mutyyeba Batool,Paolo Pastorino et al.
Syed Shabi Ul Hassan Kazmi et al.
Microplastics (MPs) have been detected across multiple maternal and neonatal biological matrices, suggesting widespread exposure during critical developmental stages. However, the mechanisms shaping their distribution and accumulation withi...
Inhalation exposure and health effects of copper particles in the context of occupational exposure limit derivation [0.03%]
职业接触限值制定过程中铜颗粒的吸入暴露及其健康效应研究
Craig A Poland,Adriana Oller,Len Levy et al.
Craig A Poland et al.
Copper is a naturally occurring element found in the Earth's crust, soil, water, and air. However, human activities such as smelting, refining, and producing copper-containing products pose a likelihood of occupational inhalation exposure. ...
Screening for the ovarian toxicity of industrial chemicals - ovarian follicles and corpora lutea counts in rats, an inter- and intra-laboratory comparison [0.03%]
工业化学品卵巢毒性的筛选-大鼠卵巢卵泡和黄体计数的实验室间和实验室内的对比研究
Olena Kucheryavenko,Karine Angeli,Vincent Bonnomet et al.
Olena Kucheryavenko et al.
The aim of this study was to identify the methodologies currently used by contract research organizations (CROs) for counting ovarian follicles and corpora lutea (CL) in the OECD Test Guideline (TG) 443 (Extended One-Generation Reproductive...
Evaluation of the modes of action for key noncancer effects of 1,3-Butadiene: input from an independent expert panel to support derivation of data-derived extrapolation factors [0.03%]
1,3-丁二烯关键非致癌效应作用模式的评估：为制定基于数据的推算因子提供独立专家小组的意见
Christopher R Kirman,John C Lipscomb,John Rogers et al.
Christopher R Kirman et al.
1,3-Butadiene (BD) is an important industrial chemical used in the production of plastics, rubbers, and polymers. This evaluation synthesizes mode of action (MOA) information to support interspecies extrapolations for key noncancer effects ...
The effect of antioxidants on antineoplastic-induced male reproductive system damage: a systematic review of experimental studies [0.03%]
抗氧化剂对化疗所致男性生殖系统损伤的影响：实验性研究的系统评价
Hale Bayram,Yaprak Dönmez Çakıl,Mustafa Erinç Sitar
Hale Bayram
Antineoplastic agents exacerbate oxidative stress and trigger inflammatory responses in the testis. Numerous studies have proposed antioxidants as a therapeutic approach to ameliorate chemotherapy-induced damage and improve reproductive out...
Weight-of-evidence assessment of the endocrine-disrupting properties of propylene oxide [0.03%]
丙烯氧化物具有内分泌干扰特性证据权重评估
Quan Shi,Erin Maloney,Satinder S Sarang et al.
Quan Shi et al.
Propylene oxide (PO) is a high-production-volume chemical widely used as an industrial intermediate and classified as carcinogen and mutagen in humans. Despite its regulatory significance, a comprehensive evaluation of its endocrine-disrupt...
The formaldehyde dispute - Part A: acute and chronic inhalation toxicity and the evolution of scientific knowledge [0.03%]
甲醛争议——急性吸入毒性和慢性吸入毒性以及科学认识的演变
Jacob Siracusa,Quincy Perry,Michael Stevens et al.
Jacob Siracusa et al.
Formaldehyde is a simple, highly reactive aldehyde whose inhalation toxicity has been characterized through more than five decades of human, animal, and mechanistic research. Across this literature, inhalation was illustrated to follow a co...