Robert F Lemanske Jr
Robert F Lemanske Jr
Asthma is a heterogenous disorder related to numerous biologic, immunologic, and physiologic components that generate multiple clinical phenotypes. Further, genetic and environmental factors interact in ways that produce variability in both...
Physiologic dysfunction of the asthmatic lung: what's going on down there, anyway? [0.03%]
哮喘患者的肺生理功能障碍：到底出了什么问题？
Charles G Irvin,Jason H T Bates
Charles G Irvin
Asthma is a syndrome of lung dysfunction characterized by airflow obstruction, reversibility to bronchodilators, and airways hyperresponsiveness (AHR). There is a growing body of evidence that suggests that the principle defect in asthma is...
Remodeling in asthma [0.03%]
哮喘的重塑
Céline Bergeron,Wisam Al-Ramli,Qutayba Hamid
Céline Bergeron
Airway remodeling refers to the structural changes that occur in both the large and the small airways of miscellaneous diseases, including asthma. In asthma, airway structural changes include subepithelial fibrosis, increased smooth muscle ...
Disrupting actin-myosin-actin connectivity in airway smooth muscle as a treatment for asthma? [0.03%]
干扰气道平滑肌中的肌动蛋白-肌球蛋白-肌动蛋白连接作为治疗哮喘的方法？
Tera L Lavoie,Maria L Dowell,Oren J Lakser et al.
Tera L Lavoie et al.
Breathing is known to functionally antagonize bronchoconstriction caused by airway muscle contraction. During breathing, tidal lung inflation generates force fluctuations that are transmitted to the contracted airway muscle. In vitro, exper...
Epithelium, inflammation, and immunity in the upper airways of humans: studies in chronic rhinosinusitis [0.03%]
人上呼吸道的上皮、炎症和免疫：慢性鼻窦炎的研究
Robert P Schleimer,Atsushi Kato,Anju Peters et al.
Robert P Schleimer et al.
The purpose of this review is to discuss recent findings made during studies of the upper airways and sinuses of people with chronic rhinosinusitis (CRS) in the context of the literature. CRS is a chronic inflammatory disorder affecting nea...
Dirkje S Postma,Gerard H Koppelman
Dirkje S Postma
Since the recognition that asthma is genetically determined, enormous progress has been made to understand which genes determine disease development in interaction with each other and/or with different environmental factors. This is the res...
Erwin W Gelfand
Erwin W Gelfand
Asthma currently affects the lives of more than 30 million Americans from infancy to the elderly. In many ways, pediatric asthma differs from adult asthma, including childhood-onset adult asthma. Despite many advances in our understanding o...
The origins of asthma and chronic obstructive pulmonary disease in early life [0.03%]
生命早期哮喘和慢性阻塞性肺病的发病原因
Fernando D Martinez
Fernando D Martinez
Results from birth cohort and cross-sectional studies of young children with wheezing have uncovered strong associations between both lung function and immune responses in early life and the subsequent development of persistent wheezing and...