Prediction of neural activity in connectome-constrained recurrent networks [0.03%]
基于连接组约束的递归神经网络中的神经活动预测
Manuel Beiran,Ashok Litwin-Kumar
Manuel Beiran
Recent technological advances have enabled measurement of the synaptic wiring diagram, or 'connectome', of large neural circuits or entire brains. However, the extent to which such data constrain models of neural dynamics and function is de...
Neeraj J Gandhi,Stephen J Heinen,Jay A Edelman et al.
Neeraj J Gandhi et al.
Cortical and subcortical mapping of the human allostatic-interoceptive system using 7 Tesla fMRI [0.03%]
利用7特斯拉fMRI映射人类适应性内感受系统的皮层和皮层下区域
Jiahe Zhang,Danlei Chen,Philip Deming et al.
Jiahe Zhang et al.
The brain continuously anticipates the body's energetic needs and prepares to meet them before they arise-a process called allostasis. To support allostasis, the brain continually models the body's sensory state, a process known as interoce...
A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging [0.03%]
小胶质细胞和星形胶质细胞昼夜基因表达图谱揭示了对淀粉样病变或衰老的反应中的细胞类型和疾病特异性重编程
Patrick W Sheehan,Stuart B Fass,Darshan Sapkota et al.
Patrick W Sheehan et al.
While circadian rhythm disruption may promote neurodegenerative disease, the impact of aging and neurodegenerative pathology on circadian gene expression patterns in different brain cell types remains unknown. Here we used a translating rib...
Sam Bryce-Smith,Anna-Leigh Brown,Max Z Y J Chien et al.
Sam Bryce-Smith et al.
Nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 are cellular hallmarks of amyotrophic lateral sclerosis (ALS). TDP-43 nuclear loss causes de-repression of cryptic exons, yet cryptic alternative polyadenylatio...
TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes [0.03%]
TDP-43核丢失引起的FTD/ALS的广泛转录变化
Yi Zeng,Anastasiia Lovchykova,Tetsuya Akiyama et al.
Yi Zeng et al.
In frontotemporal dementia and amyotrophic lateral sclerosis, the RNA-binding protein TDP-43 is depleted from the nucleus of neurons in the brain and spinal cord. A key function of TDP-43 has emerged as a repressor of cryptic exon inclusion...
Suzhou Yang,Zhen Lei,Junjie U Guo
Suzhou Yang
Oxytocin modulates respiratory heart rate variability through a hypothalamus-brainstem-heart neuronal pathway [0.03%]
催产素通过下丘脑-脑干-心脏神经途径调节呼吸性心率变异性
Julie Buron,Ambre Linossier,Christian Gestreau et al.
Julie Buron et al.
The variation in heart rate in phase with breathing is called respiratory heart rate variability (RespHRV). Relaxation and positive socio-emotional states can amplify RespHRV, yet the underlying mechanism remains largely unknown. Here we id...
A lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses [0.03%]
表达瘦素受体的下丘脑外侧部神经元群体通过对抗焦虑来促进适应性行为反应
Rebecca Figge-Schlensok,Anne Petzold,Nele Hugger et al.
Rebecca Figge-Schlensok et al.
Neuronal mechanisms that facilitate adaptive strategies to enable an animal to overcome anxiety in threatening situations remain unknown. Using single-cell calcium imaging and cell-type-specific activity manipulations in behaving mice, we i...
Differential synaptic depression mediates the therapeutic effect of deep brain stimulation [0.03%]
不同的突触抑制作用介导了深部脑刺激的治疗效果
Jicheng Li,Jingheng Zhou,Bo He et al.
Jicheng Li et al.
Deep brain stimulation (DBS) effectively treats drug-resistant neurological and psychiatric disorders, yet its mechanisms remain unclear. Here we show that high-frequency DBS of the subthalamic nucleus (STN), a common target for Parkinson's...