Jiajie Zou,David Poeppel,Nai Ding
Jiajie Zou
Next-word prediction has been hypothesized as the central computational objective of the human language system, akin to that of current large language models. Here we put this conjecture to the test, investigating whether the brain predicts...
Spatial and single-cell characterization of human glioblastoma tumor microenvironment reveals malignant cellular communities [0.03%]
空间和单细胞解析人类胶质母细胞瘤肿瘤微环境揭示恶性细胞社群
Jun Lin,Chunpeng Chen,Shouzhen Li et al.
Jun Lin et al.
Understanding the complex cellular and spatial organization of glioblastoma (GBM) and its microenvironment is crucial for improving diagnosis and treatment. Here we integrated 121 spatial transcriptomics, single-cell RNA sequencing, single-...
Spatial, temporal and Notch determination of terminal selector expression controls neuronal cell fate in the Drosophila optic lobe [0.03%]
空间、时间和Notch决定终末选择因子的表达控制果蝇光学小叶神经元细胞命运
Félix Simon,Isabel Holguera,Yen-Chung Chen et al.
Félix Simon et al.
In the medulla of the Drosophila optic lobe, the identity of each neuronal type is specified in progenitors and newborn neurons via the integration of temporal, spatial and Notch-driven patterning mechanisms. This identity is maintained in ...
Amyloid-β-driven glymphatic dysfunction in Alzheimer's disease model mice is driven by Ca2+-mediated increases in astrocytic cholesterol [0.03%]
阿尔茨海默病小鼠模型中由Ca²⁺介导的星形胶质细胞胆固醇增加驱动的淀粉样蛋白-β引起的glymphatic功能障碍
Zhan Zhang,Shaojian Li,Liang Xu et al.
Zhan Zhang et al.
Disruptions in the glymphatic system and its downstream meningeal lymphatic drainage pathway, crucial for brain waste clearance, are linked to the pathogenesis of Alzheimer's disease (AD), yet the underlying mechanisms remain unclear. Abnor...
Rapid temporal processing in the olfactory bulb underlies concentration-invariant odor identification and signal decorrelation [0.03%]
嗅球中的快速时间处理构成了浓度不变的气味识别和信号解相关功能的基础
Mursel Karadas,Jonathan V Gill,Sebastian Ceballo et al.
Mursel Karadas et al.
In a dynamic environment, sensory systems must filter out irrelevant information to construct a stable percept. Animals who rely on smell need to identify and discriminate odors despite fluctuations in concentration, yet odor receptor activ...
White matter pathways mediating dorsolateral prefrontal TMS therapy for depression [0.03%]
背外侧前额叶经颅磁刺激治疗抑郁症的白质通路机制
Caio Seguin,Sina Mansour L,Richard F Betzel et al.
Caio Seguin et al.
We use connectome modeling to map polysynaptic fiber pathways underlying transcranial magnetic stimulation (TMS) therapy for depression. We propose putative cortical and subcortical routes that connect stimulation sites in the dorsolateral ...
HSV-1 strain H129 co-opts neuronal synaptic transmission machinery for its transsynaptic spread [0.03%]
单纯疱疹病毒I型菌株H129利用神经元突触传递机器实现其跨突触传播
Hai-Bin Qin,Yue-Peng Zhou,Yang Wu et al.
Hai-Bin Qin et al.
The H129 strain (H129) of neurotropic herpes simplex virus-1 (HSV-1) is the only known HSV-1 strain that spreads transneuronally in a predominantly anterograde direction, leading to wide use for anterograde tracing in neural circuit mapping...
Talya S Kramer,Flossie K Wan,Sarah M Pugliese et al.
Talya S Kramer et al.
Complex behaviors, such as navigation, rely on sequenced motor outputs that combine to generate effective movement. The brain-wide organization of the circuits that integrate sensory signals to select appropriate motor sequences remains poo...
Henrietta Howells
Henrietta Howells
Comparing primate cerebellums [0.03%]
比较灵长类小脑
Ana Uzquiano
Ana Uzquiano