Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery [0.03%]
跨祖先的东亚和欧洲人群双相情感障碍全基因组分析提高了遗传发现率
Chu-Yi Zhang,Miao Li,Ping Sun et al.
Chu-Yi Zhang et al.
Genome-wide association studies (GWASs) of bipolar disorder (BD) have predominantly included individuals of European (EUR) ancestry, underrepresenting non-EUR populations and limiting insight into disease mechanisms. Here we performed a GWA...
A myeloid trisomy 21-associated gene variant is protective from Alzheimer's disease [0.03%]
与阿尔茨海默病作斗争：一项与先天性三体综合症相关的基因变异能起到保护作用
Mengmeng Jin,Ziyuan Ma,Rui Dang et al.
Mengmeng Jin et al.
Alzheimer's disease causes progressive cognitive decline, yet some individuals remain resilient despite developing hallmark pathology. A subset of people with Down syndrome (DS), the most common genetic cause of Alzheimer's disease, demonst...
Munc18 modulates syntaxin phase separation to promote exocytosis [0.03%]
Munc18通过调节syntaxin相分离来促进胞外转运过程
Qing Pei,Qixin Chen,Zhiqi Tian et al.
Qing Pei et al.
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein syntaxin mediates neuronal exocytosis and self-assembles into large clusters in the plasma membrane. The formation and function of these clusters, and...
Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy [0.03%]
基于来自散发性ALS患者的诱导多能干细胞衍生的运动神经元的大规模药物筛选确定了潜在的联合疗法
Christopher R Bye,Elizabeth Qian,Katherine Lim et al.
Christopher R Bye et al.
Heterogeneous and predominantly sporadic neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), remain highly challenging to model. Patient-derived induced pluripotent stem cell (iPSC) technologies offer great promise for ...
Yufeng Liu,Sujun Zhao,Zhixi Yun et al.
Yufeng Liu et al.
Brain atlases map the spatial organization of neural tissue and serve as anatomical references. Current mouse brain atlases define regions based primarily on cell density patterns but overlook how neurons extend their branches (dendrites) t...
The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia [0.03%]
莱卡内马治疗阿尔茨海默病的机制：通过诱导小胶质细胞清除淀粉样蛋白的作用削弱Aβ病理症状
Giulia Albertini,Magdalena Zielonka,Marie-Lynn Cuypers et al.
Giulia Albertini et al.
Controversies over anti-amyloid immunotherapies underscore the need to elucidate their mechanisms of action. Here we demonstrate that Lecanemab, a leading anti-β-amyloid (Aβ) antibody, mediates amyloid clearance by activating microglial e...
Tjitse van der Molen,Alex Spaeth,Mattia Chini et al.
Tjitse van der Molen et al.
Neuronal firing sequences are thought to be the building blocks of information and broadcasting within the brain. Yet, it remains unclear when these sequences emerge during neurodevelopment. Here we demonstrate that structured firing sequen...
Astrocytic Sox9 overexpression in Alzheimer's disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function [0.03%]
在阿尔茨海默病小鼠模型中星形胶质细胞Sox9过度表达促进Aβ斑块吞噬并保持认知功能
Dong-Joo Choi,Sanjana Murali,Wookbong Kwon et al.
Dong-Joo Choi et al.
Astrocytes play essential roles in the brain, and their dysfunction is associated with nearly every form of neurological disease. Despite their ubiquity, knowledge of how astrocytes contribute to disease pathogenesis is incomplete; accordin...