Strong and localized recurrence controls the dimensionality of neural activity across brain areas [0.03%]
强而集中的再现控制着整个大脑区域的神经活动维度
David Dahmen,Stefano Recanatesi,Xiaoxuan Jia et al.
David Dahmen et al.
The brain contains an astronomical number of neurons, but it is their collective activity that underlies brain function. The number of degrees of freedom that this activity explores (its dimensionality) is therefore a fundamental signature ...
Cortical thickness changes precede high levels of amyloid by at least 7 years [0.03%]
皮层厚度的改变至少早七年出现高于正常的淀粉样蛋白水平
James M Roe,William J Jagust,Susan M Landau et al.
James M Roe et al.
Alzheimer's disease is now defined by underlying pathology, with elevated amyloid-beta (Aβ) sufficient for diagnosis in the absence of cognitive symptoms. We combined longitudinal magnetic resonance imaging and Aβ positron emission tomogr...
Reusable modular architecture enables flexible cognitive operations in the mouse brain and artificial recurrent networks [0.03%]
可重复使用的模块化体系结构使小鼠大脑和人工递归网络中的认知操作更加灵活
Yuma Osako,Greggory R Heller,Sofie Ährlund-Richter et al.
Yuma Osako et al.
Complex behaviors are built by combining simpler cognitive components. Computational modeling has shown that artificial neural networks can perform a variety of tasks by flexibly combining functional modules, each specialized for a specific...
Charlotte Piette,Arnaud Hubert,Sylvie Perez et al.
Charlotte Piette et al.
One-shot learning-the ability to form memories after a single, brief salient event-is essential for behavioral flexibility in a dynamic world. However, how one-shot learning unfolds in the brain and whether it relies on distinct plasticity ...
Pyramidal cell types and circuit organization of the mouse insular cortex reveal functional specializations [0.03%]
小鼠岛叶皮层的锥体细胞类型和回路组织揭示了其功能特化点
Bart C Jongbloets,Yang Chen,Michael A Muniak et al.
Bart C Jongbloets et al.
The insular cortex integrates interoceptive and exteroceptive information to mediate bodily homeostasis, emotion and learning. However, the cellular and circuit substrates governing insular functions are poorly understood compared to primar...
Neuroligin-3-CSPG4 interaction maintains oligodendrocyte precursor cell progenitor state and promotes glioma proliferation through mechanotransduction [0.03%]
神经细胞粘附分子相互作用维持少突胶质前体细胞的干细胞性并促进glioma增殖的作用及机制研究
Yoon Seok Kim,Shawn M Gillespie,Anna C Geraghty et al.
Yoon Seok Kim et al.
Glioma pathophysiology is robustly regulated by interactions with neurons. Key to these interactions is the role of neuroligin-3 (NLGN3), a synaptic adhesion molecule shed in response to neuronal activity that functions as a paracrine facto...
Yi-Ting Chiu,Ariel Y Deutch,Wei Wang et al.
Yi-Ting Chiu et al.
Psychedelic drugs, such as lysergic acid diethylamide and psilocybin, have emerged as potentially transformative therapeutics for various neuropsychiatric conditions, including depression, anxiety, post-traumatic stress disorder, migraine a...
Joey A Charbonneau,Sarah B Carp,Jeffrey L Bennett et al.
Joey A Charbonneau et al.
The insular cortex has become an increasingly important focus of neuroscientific research because of its broad involvement in psychological and behavioral processes and its dysfunction in neuropsychiatric, developmental, degenerative and me...
Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells [0.03%]
海马CA3连接组学揭示了苔藓纤维输入和选择性前向抑制在锥体细胞中的梯度分布规律
Zhihao Zheng,Changjoo Park,Eric W Hammerschmith et al.
Zhihao Zheng et al.
The mossy fiber (MF) connections to pyramidal cells in hippocampal CA3 are thought to participate in pattern separation, pattern completion and memory encoding, yet no large-scale neuronal wiring diagram exists for these connections. We ass...
Norepinephrine and dopamine sensor crosstalk depends on local innervation density [0.03%]
去甲肾上腺素和多巴胺传感器交叉对话取决于局部神经支配密度
Ricardo C López,Natalie Noble,Özge D Özçete et al.
Ricardo C López et al.
G-protein-coupled receptor-based fluorescent sensors are widely used to correlate neuromodulatory signaling with brain function. Although experiments in transfected cells often reveal selectivity for individual neurotransmitters, sensor spe...