Human hippocampal ripples coordinate planning sequences and compositional representations in neocortex [0.03%]
人脑海马区尖波涟漪协调新皮层规划序列及组成式表征
Li He,Xiongfei Wang,Jinbo Zhang et al.
Li He et al.
The human brain excels at solving novel problems by flexibly recombining a limited set of familiar elements, often through the internal planning of sequences that assemble these elements into new configurations. Although the hippocampus and...
Daan Verhaege,Jonathan Kipnis
Daan Verhaege
Molecular mechanism of calcium permeability and magnesium block in NMDA receptors [0.03%]
NMDA受体钙离子通透性及镁离子阻滞的分子机制研究
Ruben Steigerwald,Max Epstein,Tsung-Han Chou et al.
Ruben Steigerwald et al.
Hebbian neuroplasticity, which is thought to be a cellular substrate of learning and memory, can occur by means of coincidental detection of presynaptic neurotransmitter release and Ca2+ influx upon postsynaptic depolarization. This is medi...
Phasing out animal research prematurely will maintain gender inequities in medicine [0.03%]
过早取消动物研究将会在医学上维持性别不公
Irina Kovlyagina,Ivana Jaric
Irina Kovlyagina
Yunlong Liu,Jiaoyang Wo,Emily E Kramer et al.
Yunlong Liu et al.
Traumatic events produce enduring memories that may be attenuated through extinction learning. Previous work has identified neuronal mechanisms underlying extinction learning that involve the remodeling or inhibition of neuronal ensembles (...
Stochastic growth and ligand-receptor interaction-mediated stabilization generate stereotyped dendritic arbors [0.03%]
随机生长和配体-受体相互作用介导的稳定化生成 stereotype 树突 Arbor
Rebecca Shi,Xue Yan Ho,Li Tao et al.
Rebecca Shi et al.
Stereotyped dendritic arbors are shaped by dynamic and stochastic growth during neuronal development. It remains unclear how guidance receptors and ligands coordinate branch dynamic growth, retraction and stabilization to specify dendritic ...
A communication subspace relays context-dependent actions from human prefrontal to motor cortex [0.03%]
一个通信子空间从人类前额叶皮层向运动皮层传递上下文依赖性动作
Neha Binish,Jonas Terlau,Jan Martini et al.
Neha Binish et al.
Adaptive behavior relies on the ability to translate abstract rules and goals into actions suited to the current context. Neural population activity in the prefrontal cortex (PFC) has been proposed to support such flexible computations thro...
Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation [0.03%]
依赖葡萄糖的ACLY调节组蛋白乙酰化调控少突胶质前体细胞增殖的时空变化规律
Sami Sauma,Stephanie Stransky,Ipek Selcen et al.
Sami Sauma et al.
How it is determined whether postnatal oligodendrocyte progenitor cells (OPCs) will survive, proliferate or differentiate remains unclear. Here we suggest that temporal and brain regional fluctuations of glucose, concomitant with changes in...
Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges [0.03%]
调控人类癫痫样放电的人类皮层微环路的层状结构组织
Alexander B Silva,Siddharth A Marathe,Quinn R Greicius et al.
Alexander B Silva et al.
Interictal epileptiform discharges (IEDs) are pathological bursts of brain activity between seizures in people with epilepsy. Despite their importance in diagnosis, cognitive comorbidities and therapeutic implications as biomarkers for neur...
A septo-entorhinal GABAergic pathway that enables switching between episodic memories [0.03%]
介导情景记忆之间转换的隔区-内侧内嗅皮层GABA能环路
Mujun Kim,Boin Suh,Sunhoi So et al.
Mujun Kim et al.
New experiences are integrated with existing knowledge to update memory, which is essential for survival in a dynamic environment. Despite this updating, the brain can still access previous memories to guide appropriate behavior. How the br...