Electrophysiological classification of human layer 2-3 pyramidal neurons reveals subtype-specific synaptic interactions [0.03%]
人脑皮层2/3层锥体神经元的电生理分类揭示亚型特异性突触交互作用
Henrike Planert,Franz Xaver Mittermaier,Sabine Grosser et al.
Henrike Planert et al.
Understanding the functional principles of the human brain requires deep insight into its neuronal and network physiology. In superficial layers of temporal cortex, molecular and morphological subtypes of glutamatergic excitatory pyramidal ...
Multi-region m6A epitranscriptome profiling of the human brain reveals spatial and temporal variation and enrichment of disease-associated loci [0.03%]
人脑多区域m6A表转录组测序揭示了时空差异及疾病相关位点的富集现象
Andrew M Shafik,Yong Peng,Zijie Zhang et al.
Andrew M Shafik et al.
N6-methyladenosine (m6A) is a major RNA modification in the brain, regulating neural processes and contributing to disease mechanisms. Despite its importance, regional, age-specific and sex-specific m6A patterns in the human brain are still...
Convergent information flows explain recurring firing patterns in cerebral cortex [0.03%]
汇聚的信息流解释了大脑皮层中重复的放电模式
Domenico Guarino,Anton Filipchuk,Alain Destexhe
Domenico Guarino
Cortical population events, short-lived patterns of neuronal activity that recur with consistency, are central to sensorimotor coordination. These reproducible firing patterns are often attributed to attractor dynamics, supported by strong ...
Patterned wireless transcranial optogenetics generates artificial perception [0.03%]
基于无线的经颅光遗传学产生人工感知
Mingzheng Wu,Yiyuan Yang,Jinglan Zhang et al.
Mingzheng Wu et al.
Synthesizing perceivable artificial neural inputs independent of typical sensory channels remains a fundamental challenge in developing next-generation brain-machine interfaces. Establishing a minimally invasive, wirelessly effective and mi...
Matthew A Geramita,Susanne E Ahmari,Eric A Yttri
Matthew A Geramita
Hesitation-that is, pausing an action in the face of uncertainty-is ubiquitous in daily life, yet little is known about its underlying neural circuitry. We present a new experimental paradigm that reliably evokes hesitation in mice and find...
Rapid motor skill adjustment is associated with population-level modulation of cerebellar error signals [0.03%]
与小脑误差信号的群体水平调节相关的快速运动技能调整
Vinh Nguyen,Capucine Gros,Brandon M Stell
Vinh Nguyen
A core principle of cerebellar learning theories is that climbing fibers from the inferior olive convey error signals about movement execution to Purkinje cells in the cerebellar cortex. These inputs trigger synaptic changes, which are purp...
In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation [0.03%]
在体CRISPR筛选揭示了神经炎症中巨噬细胞状态的调控
Clara de la Rosa,Arek Kendirli,Seren Baygün et al.
Clara de la Rosa et al.
Here we established an in vivo CRISPR screening pipeline using genetically editable progenitor cells to dissect macrophage regulation in mouse models of multiple sclerosis (MS). Screening over 100 cytokine receptors and signaling molecules ...
Ana Uzquiano
Ana Uzquiano
When protein turns toxic [0.03%]
当蛋白质变成有毒物质时
Ioana A Marin
Ioana A Marin