Cold and lithium delay forgetting of olfactory memories in Caenorhabditis elegans [0.03%]
冷和锂通过抑制Caenorhabditis elegans的蛋白质翻译而延缓其嗅觉记忆的丢失
Dana Landschaft-Berliner,Kesem Goldstein,Guy Teichman et al.
Dana Landschaft-Berliner et al.
The persistence of memory reflects not only how it is formed but also how forgetting is delayed. The mechanisms controlling forgetting remain obscure, and in particular it is unclear to what degree this process is actively regulated. We dis...
Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons [0.03%]
磷酸化的tau蛋白具有抗菌活性能够中和单纯疱疹病毒1型感染人类神经元的能力
William A Eimer,Alex S Rodriguez,Michael T DeFao et al.
William A Eimer et al.
Tau is a microtubule-associated cytoskeletal protein, which, when hyperphosphorylated and aggregated, can result in a myriad of different tauopathies, including Alzheimer's disease (AD). We previously showed that the principal component of ...
BOLD signal changes can oppose oxygen metabolism across the human cortex [0.03%]
_BOLD信号改变可以对抗人类皮层中的氧代谢_
Samira M Epp,Gabriel Castrillón,Beijia Yuan et al.
Samira M Epp et al.
Functional magnetic resonance imaging measures brain activity indirectly by monitoring changes in blood oxygenation levels, known as the blood-oxygenation-level-dependent (BOLD) signal, rather than directly measuring neuronal activity. This...
The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling [0.03%]
Foxf2卒中风险基因通过Tie2信号维持脑内皮细胞功能
Katalin Todorov-Völgyi,Judit González-Gallego,Stephan A Müller et al.
Katalin Todorov-Völgyi et al.
Cerebral small vessel disease (SVD) is a common chronic cerebrovascular disorder with poorly understood pathomechanisms. Genetic studies have identified FOXF2 as a major risk gene for both SVD and stroke. FOXF2 encodes a transcription facto...
A fully iPS-cell-derived 3D model of the human blood-brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions [0.03%]
一种用于探索神经血管疾病机制和治疗干预措施的人类血脑屏障的全iPSc来源的三维模型
Judit González-Gallego,Katalin Todorov-Völgyi,Stephan A Müller et al.
Judit González-Gallego et al.
Blood-brain barrier (BBB) integrity is critical for brain homeostasis, with malfunctions contributing to neurovascular and neurodegenerative disorders. Mechanistic studies on BBB function have been mostly conducted in rodent and in vitro mo...
Alex James Major,Ahmed Abdaltawab,Jessica M Phillips et al.
Alex James Major et al.
Is there a ubiquitous spectrolaminar motif of local field potential power across primate neocortex? [0.03%]
灵长类新皮层局灶场电位功率的普遍存在规则吗？
Chase A Mackey,Katharina Duecker,Samuel Neymotin et al.
Chase A Mackey et al.
Bright light exposure suppresses feeding and weight gain via a visual circuit linked to the lateral hypothalamus [0.03%]
亮光通过与下丘脑外侧区相连的视觉通路抑制摄食和体重增加
Wen Li,Xiaodan Huang,Xiaohuai Xu et al.
Wen Li et al.
Environmental light regulates nonimage-forming functions like feeding, and bright light therapy shows anti-obesity potential, yet its neural basis remains unclear. Here we show that bright light treatment effectively reduces food intake and...
Single-cell spatiotemporal transcriptomic and chromatin accessibility profiling in developing postnatal human and macaque prefrontal cortex [0.03%]
发育后人类和恒河猴额皮层的单细胞时空转录组和染色质可及性分析
Jiyao Zhang,Mayuqing Li,Mengdi Wang et al.
Jiyao Zhang et al.
Unraveling the cellular and molecular characteristics of human prefrontal cortex (PFC) development is crucial for understanding human cognitive abilities and vulnerability to neurological and neuropsychiatric disorders. Here, in this study,...
A hippocampal 'sharp-wave sleep' state that is dissociable from cortical sleep [0.03%]
一种与皮层睡眠分离的海马“锐波睡眠”状态
Graham Findlay,Matias Lorenzo Cavelli,Tom Bugnon et al.
Graham Findlay et al.
Cortical slow waves reflect the need for sleep, and their presence indicates a state of disconnection and homeostatic regulation. However, little is known about the neural signatures of sleep need beyond the cortex. Here we performed chroni...