David E Lozano,Jiso Hong,Xi Jin et al.
David E Lozano et al.
Rapid-eye-movement (REM) sleep is generated in the brainstem, but the brainstem population dynamics that drive transitions to REM sleep remain largely unknown. Here, combining mouse Neuropixels recordings and dimensionality reduction, we fo...
Fixation duration on natural scenes is explained by memory encoding not processing demand [0.03%]
自然场景的固定时间是由记忆编码而不是处理需求解释的
Philip Sulewski,Carmen Amme,Martin N Hebart et al.
Philip Sulewski et al.
Before each of around 200,000 eye movements we make each day, the brain decides how long to fixate before shifting gaze to new information. Here we investigate this process using a large-scale scene-viewing experiment (4,080 natural scenes,...
Foamy microglia link oxylipins to disease progression in multiple sclerosis [0.03%]
泡沫型小胶质细胞将多发性硬化中氧化脂质代谢产物与疾病进展相联系
Daan van der Vliet,Xinyu Di,Tatiana M Shamorkina et al.
Daan van der Vliet et al.
Multiple sclerosis (MS) is a chronic neuroinflammatory disease in which demyelinating white matter lesions accumulate and expand, driving irreversible disability. Here we identify a distinct population of foamy GPNMB+ microglia/macrophages ...
Tau aggregates cause reactivation of transposable DNA elements, leading to Z-RNA-ZBP1-mediated neuronal death [0.03%]
tau聚集物引起转座DNA元件活化导致Z-RNA-ZBP1介导的神经元死亡
Wei Liu,Song-Ang Wu,Bo-Xin Zhang et al.
Wei Liu et al.
Once tau aggregates are formed, their neurotoxicity significantly contributes to neuronal death and cognitive decline in tauopathies, with Alzheimer's disease being the most well-known example. Despite its central pathogenic role, however, ...
Lorenzo Pini,Alessandro Salvalaggio,Maurizio Corbetta
Lorenzo Pini
Spatial proteomic analysis in human Alzheimer's disease brains enables identification of microenvironment-dependent microglial cell states [0.03%]
空间蛋白质组学分析人类阿尔茨海默病大脑可识别与微环境依赖的的小胶质细胞状态
Paula Sanchez-Molina,Dennis-Dominik Rosmus,Dillon Brownell et al.
Paula Sanchez-Molina et al.
Disease-associated microglial states are thought to contribute to Alzheimer's disease (AD) progression, but characterizing them and their relationships to pathology remains challenging. Here we introduce CODEX-CNS-a multiplexed protein imag...
Tatiana A Shnitko,Shih-Che Alex Lin,Yen-Yu Ian Shih
Tatiana A Shnitko
Autism subtypes identified using cross-species functional connectivity analyses [0.03%]
利用跨物种功能连接分析确定自闭症亚型
Marco Pagani,Valerio Zerbi,Silvia Gini et al.
Marco Pagani et al.
It is often assumed that phenotypic heterogeneity in autism reflects underlying pathobiological variation. However, direct evidence supporting this link is lacking. Leveraging cross-species functional neuroimaging, we show that brain dyscon...
Excitatory synapses onto axonic spines jump-start action potentials and route information flow [0.03%]
兴奋性突触通过轴突棘启动动作电位并调节信息流方向
Hongkun Yang,Kun Wang,Yijie Chen et al.
Hongkun Yang et al.
Synaptic inputs onto the dendrites and cell body integrate and trigger action potentials (APs) at the axon initial segment (AIS). The AIS receives GABAergic synaptic inputs; however, the structure and function of glutamatergic synapses at t...
Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming [0.03%]
整合单细胞和空间转录组分析揭示ALS中免疫浸润及重编程现象
Ziyang Zhang,Lynn van Olst,Francesco Alessandrini et al.
Ziyang Zhang et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder marked by progressive motor neuron (MN) degeneration in the brain and spinal cord. Although neuroinflammation is increasingly recognized as a hallmark of ALS, the pre...