Representations of the intrinsic value of information in mouse orbitofrontal cortex [0.03%]
小鼠眶额皮层内在价值信息的神经元表征
Jennifer J Bussell,Ryan P Badman,David Márton et al.
Jennifer J Bussell et al.
Animals are motivated to seek information that does not influence reward outcomes, suggesting that information has intrinsic value. Here we have developed an odor-based information seeking task that reveals that mice choose to receive infor...
Shai Israel,Moshe Parnas
Shai Israel
Creating true and false memories from forgotten information in Drosophila [0.03%]
用果蝇制造真实的和虚假的遗忘信息记忆
Wenbin Yang,Benedetta Zattera,Miguel Pavão-Delgado et al.
Wenbin Yang et al.
Recovering forgotten memories is a double-edged sword. While regaining access to forgotten information can be advantageous, targeted memory recovery carries the risk of generating false memories. The neuronal processes governing true memory...
The cross-site reproducibility of MRI morphometric phenotypes in psychiatric disorders [0.03%]
精神疾病磁共振图像形态表型的跨站点重现性研究
Trang Cao,James C Pang,Mehul Gajwani et al.
Trang Cao et al.
Decades of structural magnetic resonance imaging (MRI) studies have documented alterations of gray matter morphometry in psychiatric disorders, but the field has failed to identify any consensus disease phenotypes. Here we examine whether c...
Aaron Alexander-Bloch,Armin Raznahan
Aaron Alexander-Bloch
Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease [0.03%]
线粒体堆积和溶酶体功能障碍导致阿尔茨海默病中形成线粒体斑点现象
Xiuli Dan,Deborah L Croteau,Wenlong Liu et al.
Xiuli Dan et al.
Dysfunctional mitophagy is proposed as a key component of Alzheimer's disease (AD) pathology, yet direct in vivo evidence and mechanistic insights are still lacking. Here we show that AD model mice expressing a mitophagy reporter (APP/PSEN1...
cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy [0.03%]
cGAS介导的I型干扰素信号通路参与难治性癫痫发病进展
Yige Huang,Li Fan,Man Ying Wong et al.
Yige Huang et al.
Epilepsy is a prevalent neurological disease, with one-third of individuals becoming nonresponsive to antiepileptic drugs and developing drug-refractory epilepsy (DRE). Here we identify activation of cyclic GMP-AMP synthase (cGAS), a double...
Saman Abbaspoor,Ayman Aljishi,Kari L Hoffman
Saman Abbaspoor
Memory formation relies on the reorganization of neural activity patterns during experience that persist in subsequent sleep. How these processes promote learning while preserving established memories remains unclear. Here we recorded neura...
Emmett J Thompson,Lars B Rollik,Benjamin Waked et al.
Emmett J Thompson et al.
Sleep is crucial for consolidating all forms of memory and a core mechanism underlying this process is offline replay. Current models propose that replay originates in the hippocampus and triggers reactivation across cortical and subcortica...
Focal astrocyte loss reveals nuclear translocation during lesion repopulation [0.03%]
焦性胶质细胞丢失揭示了病变再殖民期间的核定位转移现象
Marina Herwerth,Matthias T Wyss,Nicola B Schmid et al.
Marina Herwerth et al.
Astrocyte loss occurs in various neurological conditions and can disrupt local tissue homeostasis. While astrocytes surrounding border-forming lesions adopt reactive states without restoring astrocyte networks, how astrocytes respond to spa...