A brainstem pathway underlying vagal modulation of somatic pain and affective states [0.03%]
脑干通路影响膈神经调节躯体疼痛和情感状态
Yuan Tang,Ruixinzhu Shao,Liuxinyu Luo et al.
Yuan Tang et al.
Vagus nerve stimulation (VNS) alleviates pain, yet the underlying neural mechanisms remain elusive. Furthermore, the caudal nucleus of the solitary tract (cNTS) receives vagal and somatic inputs, but how it transforms pain signals into beha...
Single-cell multi-omic atlas and morphogen screening informs midbrain and hindbrain organoid engineering [0.03%]
单细胞多组学图谱和形态发生素筛选可指导中脑和后脑类器官工程
Nadezhda Azbukina,Zhisong He,Hsiu-Chuan Lin et al.
Nadezhda Azbukina et al.
Patterning of the neural tube establishes midbrain and hindbrain structures that coordinate motor movement, process sensory input and integrate cognitive functions. Cellular impairment within these structures underlies diverse neurological ...
Microbial reactivation of host androgens directs enteric neuronal regulation of gut motility [0.03%]
肠道神经元对肠动力调节的宿主雄激素微生物再活化作用
Valentina N Lagomarsino,Ariel Robinson,Perry E Mitchell et al.
Valentina N Lagomarsino et al.
The coordinated transit of intestinal contents is crucial for digestion and host defense, and is regulated by cross-talk between neural circuits, the muscular gut wall and luminal factors. Here we show that androgen signaling to Nos1+ enter...
Jan Vollert,Esther Pogatzki-Zahn,Joletta Belton et al.
Jan Vollert et al.
Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks [0.03%]
深部脑刺激诱导白质重塑和全脑功能网络变化
Satoka H Fujimoto,Atsushi Fujimoto,Catherine Elorette et al.
Satoka H Fujimoto et al.
Deep brain stimulation (DBS) is an emerging therapy for treatment-resistant neurological and psychiatric disorders. Despite this, little is known about the anatomical and functional mechanisms that underlie this therapy. We targeted DBS to ...
Choong-Wan Woo
Choong-Wan Woo
Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner [0.03%]
载脂蛋白E基因型和年龄依赖性神经蛋白酶体调节内源性tau双螺旋细丝形成
Victoria Paradise,Kalin D Konrad-Vicario,Chi Nguyen et al.
Victoria Paradise et al.
In Alzheimer's disease (AD), endogenous tau undergoes a pathogenic transition to form paired helical filaments (PHFs), but the cellular mechanisms driving this process have been elusive. Here, we identify the neuron-specific plasma membrane...
João Filipe Oliveira,Amit Agarwal,Ruth Beckervordersandforth et al.
João Filipe Oliveira et al.
Astrocytes modulate brain processes such as neurotransmitter signaling, ion homeostasis, vascular tone, metabolism and synaptic transmission, and serve a critical role in complex brain functions. However, it remains unclear on which spatial...
Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice [0.03%]
小胶质细胞线粒体通过富GPNMB胞外囊泡转导给星形胶质细胞以缓解tau病小鼠的认知缺陷
Chensi Liang,Yulan Zhou,Kai Zhuang et al.
Chensi Liang et al.
Alzheimer's disease (AD) is an irreversible neurodegenerative disease characterized by cognitive decline. The precise molecular mechanisms that underlie the pathogenesis of AD remain elusive. Here we show that glycoprotein nonmetastatic mel...