Extracellular matrix proteolysis maintains synapse plasticity during brain development [0.03%]
细胞外基质蛋白酶解在脑发育期间维持突触可塑性
Haruna Nakajo,Ran Cao,Supriya A Mula et al.
Haruna Nakajo et al.
The extracellular matrix (ECM) regulates synaptic plasticity via mechanisms that are still being defined and have been studied predominantly in adulthood. Here, using live imaging of excitatory synapses in zebrafish hindbrain, we observed a...
Axonal Eif5a hypusination controls local translation and mitigates defects in FUS-ALS [0.03%]
轴突Eif5a去甲基化控制局部翻译并减轻FUS-ALS缺陷
Diana Piol,Bilal Khalil,Tessa Robberechts et al.
Diana Piol et al.
Local protein synthesis is vital for neuronal function, but its dysregulation in neurodegenerative diseases remains poorly defined. Here we applied spatial transcriptomics to adult mouse motor nerve axons and cell bodies to enable subcellul...
Genetic mapping identifies Homer1 as a developmental modifier of attention [0.03%]
基因图谱鉴定出Homer1为注意的发育调节因子
Zachary Gershon,Alessandra Bonito-Oliva,Matt Kanke et al.
Zachary Gershon et al.
The genetic factors and resulting neural circuit physiology driving variation in attention are poorly understood. Here we took an unbiased forward genetics approach to identify genes of large effect on attention. We studied 200 genetically ...
Behavioral adaptation to warm conditions via Lim1-mediated acceleration of neuronal clocks [0.03%]
Lim1介导的神经节律时钟加速促进适应温暖环境的行为反应
Zhihua Liu,Dapeng Xie,Stephen X Zhang et al.
Zhihua Liu et al.
Temperature compensation stabilizes the speed of circadian clocks. Uncompensated molecular clock cycles would accelerate severalfold with each 10 °C increase, precluding reliable timekeeping. Despite such thermal buffering, some clock-cont...
CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer's disease [0.03%]
利用人源星形胶质细胞CRISPRi筛选发现阿尔茨海默病相关远端增强子
Nicole F O Green,Gavin J Sutton,Javier Pérez-Burillo et al.
Nicole F O Green et al.
Genetic variants associated with complex traits often lie in distal enhancers. While candidate enhancers have been mapped genome wide, their functional state and gene targets in specific cell types remain unclear. Here we present AstroREG, ...
Cold and lithium delay forgetting of olfactory memories in Caenorhabditis elegans [0.03%]
冷和锂通过抑制Caenorhabditis elegans的蛋白质翻译而延缓其嗅觉记忆的丢失
Dana Landschaft-Berliner,Kesem Goldstein,Guy Teichman et al.
Dana Landschaft-Berliner et al.
The persistence of memory reflects not only how it is formed but also how forgetting is delayed. The mechanisms controlling forgetting remain obscure, and in particular it is unclear to what degree this process is actively regulated. We dis...
Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons [0.03%]
磷酸化的tau蛋白具有抗菌活性能够中和单纯疱疹病毒1型感染人类神经元的能力
William A Eimer,Alex S Rodriguez,Michael T DeFao et al.
William A Eimer et al.
Tau is a microtubule-associated cytoskeletal protein, which, when hyperphosphorylated and aggregated, can result in a myriad of different tauopathies, including Alzheimer's disease (AD). We previously showed that the principal component of ...
BOLD signal changes can oppose oxygen metabolism across the human cortex [0.03%]
_BOLD信号改变可以对抗人类皮层中的氧代谢_
Samira M Epp,Gabriel Castrillón,Beijia Yuan et al.
Samira M Epp et al.
Functional magnetic resonance imaging measures brain activity indirectly by monitoring changes in blood oxygenation levels, known as the blood-oxygenation-level-dependent (BOLD) signal, rather than directly measuring neuronal activity. This...
The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling [0.03%]
Foxf2卒中风险基因通过Tie2信号维持脑内皮细胞功能
Katalin Todorov-Völgyi,Judit González-Gallego,Stephan A Müller et al.
Katalin Todorov-Völgyi et al.
Cerebral small vessel disease (SVD) is a common chronic cerebrovascular disorder with poorly understood pathomechanisms. Genetic studies have identified FOXF2 as a major risk gene for both SVD and stroke. FOXF2 encodes a transcription facto...