Luis B Barreiro,Musa M Mhlanga
Luis B Barreiro
Genetics and environment distinctively shape the human immune cell epigenome [0.03%]
遗传和环境独特地塑造人类免疫细胞表观基因组
Wenliang Wang,Manoj Hariharan,Wubin Ding et al.
Wenliang Wang et al.
The epigenome of human immune cells is shaped by both genetics and environmental factors, yet the relative contributions of these influences remain incompletely characterized. Here we use single-nucleus methylation sequencing and assay for ...
Reply to: a quantitative trait locus for reduced microglial APOE expression associates with reduced cerebral amyloid angiopathy [0.03%]
关于APOE小胶质细胞定量性状位点与脑淀粉样血管病减少相关性的回复
Lincoln M P Shade,Qi Qiao,Yuriko Katsumata et al.
Lincoln M P Shade et al.
A quantitative trait locus for reduced microglial APOE expression associates with reduced cerebral amyloid angiopathy [0.03%]
与脑淀粉样血管病降低相关的载脂蛋白E小胶质细胞表达减少的定量性状位点
Michael E Belloy,Jonathan Graff-Radford,Michael D Greicius
Michael E Belloy
Single-cell atlas of the transcriptome and chromatin accessibility in the human retina [0.03%]
人类视网膜转录组和染色质可及性单细胞图谱
Jin Li,Jun Wang,Ignacio L Ibarra et al.
Jin Li et al.
Single-cell sequencing has revolutionized the scale and resolution of molecular profiling of tissues and organs. Here we present an integrated dual-modal reference atlas of the most accessible portion of the mammalian central nervous system...
Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病的异质性中潜在的异常细胞群落
Yuening Zhang,Huanhuan Wei,Jessica Nouws et al.
Yuening Zhang et al.
Chronic obstructive pulmonary disease (COPD) is clinically and molecularly heterogeneous. To investigate COPD heterogeneity, we profiled lung tissue by single-nucleus RNA sequencing from 141 study participants (1,516,727 nuclei) and identif...
Haochen Zhang,Palash Sashittal,Elias-Ramzey Karnoub et al.
Haochen Zhang et al.
Most evolutionary studies on pancreatic cancer rely on bulk sequencing, yet clonal evolution happens at the single-cell level. We used single-nucleus DNA sequencing to study 137,491 single nuclei from 24 pancreatic neoplasms reflecting vari...
Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants [0.03%]
糖基化过程的人类遗传易感性在SARS-CoV-2感染（特别是奥密克戎变异株）中的中心作用
Frank Geller,Xiaoping Wu,Vilma Lammi et al.
Frank Geller et al.
The host genetics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have previously been studied based on cases from the earlier waves of the pandemic in 2020 and 2021, identifying 51 genomic loci associated with infection and...
Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction [0.03%]
多性状和多祖先的遗传分析改善了共病肺疾病和特征的基因组发现和多基因风险预测能力
Yixuan He,Wenhan Lu,Yon Ho Jee et al.
Yixuan He et al.
While respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma share many risk factors, most studies investigate them in isolation and in predominantly European-ancestry populations. Here, we conducted the most p...
Jonathan Mitchel,Teng Gao,Viktor Petukhov et al.
Jonathan Mitchel et al.
Spatial transcriptomics aims to elucidate how cells coordinate within tissues by connecting cellular states to their native microenvironments. Imaging-based assays are especially promising, capturing molecular and cellular features at subce...