Ferric carboxymaltose for anemia in late pregnancy: a randomized controlled trial [0.03%]
富铁卡马藤治疗妊娠晚期贫血的随机对照试验
Sant-Rayn Pasricha,Ernest Moya,Ricardo Ataíde et al.
Sant-Rayn Pasricha et al.
Over 46% of African pregnant women are anemic. Oral iron is recommended but often suboptimal, particularly late in pregnancy. Intravenous ferric carboxymaltose (FCM) could treat anemia in women in the third trimester in sub-Saharan Africa. ...
Glecirasib in KRASG12C-mutated nonsmall-cell lung cancer: a phase 2b trial [0.03%]
KRAS G12C抑制剂glecirasib治疗非小细胞肺癌的IIb期临床试验
Yuankai Shi,Jian Fang,Ligang Xing et al.
Yuankai Shi et al.
Glecirasib (JAB-21822) is a new covalent oral KRAS-G12C inhibitor. This multicenter, single-arm phase 2b study assessed the efficacy and safety of glecirasib administered orally at 800 mg daily in patients with locally advanced or metastati...
Neoadjuvant chemoradiation with or without PD-1 blockade in locally advanced rectal cancer: a randomized phase 2 trial [0.03%]
局部晚期直肠癌新辅助化放疗联合或不联合PD-1阻断的一项随机II期临床试验
Yingchi Yang,Kai Pang,Guole Lin et al.
Yingchi Yang et al.
Radiotherapy displays unique antitumor synergism with immune checkpoint inhibitors, which is indicated by high pathological complete response (pCR) rates from single-arm trials of locally advanced rectal cancer (LARC). Here we test the effi...
Debashree Goswami,Stefan H I Kappe
Debashree Goswami
Resurgence of malaria and artemisinin resistance in Africa requires a concerted response [0.03%]
非洲疟疾死灰复燃和青蒿素抗药性亟需采取联合应对措施
Nebiyu Dereje,Mosoka Papa Fallah,Tamrat Shaweno et al.
Nebiyu Dereje et al.
Singing for health: a participatory process to design a song-based intervention for hypertension [0.03%]
歌唱促健康：高血压歌曲干预措施的参与式设计过程
Ifedola I Olojo,Chidi Okafor,Ihediwa F Chimchetaram et al.
Ifedola I Olojo et al.
Personalized, autologous neoantigen-specific T cell therapy in metastatic melanoma: a phase 1 trial [0.03%]
黑色素瘤自体新生抗原特异性T细胞治疗一期临床试验
Jessica S W Borgers,Divya Lenkala,Victoria Kohler et al.
Jessica S W Borgers et al.
New treatment approaches are warranted for patients with advanced melanoma refractory to immune checkpoint blockade (ICB) or BRAF-targeted therapy. We designed BNT221, a personalized, neoantigen-specific autologous T cell product derived fr...
Effects of conditional cash transfers on tuberculosis incidence and mortality according to race, ethnicity and socioeconomic factors in the 100 Million Brazilian Cohort [0.03%]
巴西1亿人口队列中针对种族、民族和经济社会因素的条件性现金转移对结核病发病率和死亡率的影响
Gabriela S Jesus,Priscila F P S Gestal,Andrea F Silva et al.
Gabriela S Jesus et al.
Conditional cash transfer (CCT) programs have been implemented globally to alleviate poverty. Although tuberculosis (TB) is closely linked to poverty, the effects of CCT on TB outcomes among populations facing social and economic vulnerabil...
Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survival [0.03%]
胰腺导管腺癌的临床基因组特征确定KRAS点突变的剂量是影响总体存活率的因素
Anna M Varghese,Maria A Perry,Joanne F Chou et al.
Anna M Varghese et al.
Nearly all pancreatic adenocarcinomas (PDAC) are genomically characterized by KRAS exon 2 mutations. Most patients with PDAC present with advanced disease and are treated with cytotoxic therapy. Genomic biomarkers prognostic of disease outc...
Evaluating generalizability of oncology trial results to real-world patients using machine learning-based trial emulations [0.03%]
利用基于机器学习的试验仿真评估肿瘤试验结果对现实世界患者群体的适用性
Xavier Orcutt,Kan Chen,Ronac Mamtani et al.
Xavier Orcutt et al.
Randomized controlled trials (RCTs) evaluating anti-cancer agents often lack generalizability to real-world oncology patients. Although restrictive eligibility criteria contribute to this issue, the role of selection bias related to prognos...