Editorial Expression of Concern: CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis [0.03%]
编辑部关注函：CDK4与Ras共表达导致恶性人类表皮肿瘤发生
Mirella Lazarov,Yoshiaki Kubo,Ti Cai et al.
Mirella Lazarov et al.
Global access to different classes of diabetes medicines: a framework for targeted policy actions [0.03%]
糖尿病药物的全球可及性：针对不同药物类别的政策行动框架
Felix Teufel,Nomathemba Chandiwana,Roopa Shivashankar et al.
Felix Teufel et al.
Nigam H Shah,Niraj Sehgal,Euan A Ashley et al.
Nigam H Shah et al.
Luca Paruzzo,Emeline R Chong,Elise A Chong et al.
Luca Paruzzo et al.
Chimeric antigen receptor (CAR) T cell therapy induces durable remissions in lymphoid malignancies, yet the extent and biology of long-term CAR T cell persistence in B cell lymphoma remain unclear. Here we report the persistence and charact...
Obinutuzumab β for aquaporin-4-positive neuromyelitis optica spectrum disorder: a phase 3 randomized controlled trial [0.03%]
奥比妥珠单抗β治疗AQP4阳性神经脊髓炎谱系障碍III期随机对照试验
Lei Wu,Liangliang Gu,Weihao Fan et al.
Lei Wu et al.
Although CD20-directed B cell depletion has long been used in neuromyelitis optica spectrum disorder (NMOSD), high-quality, large-scale, randomized controlled trials remain limited. In this multicenter, randomized, double-blind phase 3 tria...
Yiying Wang,Jennifer L Sargent,Chantal Mathieu et al.
Yiying Wang et al.
Type 2 diabetes (T2D) prevention efforts have largely focused on intervening when dysglycemia is already established. We propose that T2D prevention be reframed around prediabetes remission, with preservation and restoration of normoglycemi...
Large-scale whole-genome sequencing reveals the landscape and health implications of de novo mutations [0.03%]
大规模从头测序揭示新生突变的图谱及其对健康的潜在影响
Na Qin,Juncheng Dai,Yue Jiang et al.
Na Qin et al.
De novo mutations (DNMs) are an important source of congenital diseases. With delayed parenthood and assisted reproductive technology (ART) use increasing, it is essential to elucidate how these reproductive factors influence DNMs and wheth...
A clinically validated framework for auditing AI chatbot behavior in mental health interactions [0.03%]
一种经过临床验证的框架，用于审计AI聊天机器人在心理健康互动中的行为
Veith Weilnhammer,Kevin Yc Hou,Lennart Luettgau et al.
Veith Weilnhammer et al.
Millions of users turn to consumer artificial intelligence chatbots to discuss emotional, behavioral and mental-health concerns, creating an urgent need for rigorous and scalable safety evaluations. Here we introduce simulated (SIM) vulnera...
Intracranial delivery of B7-H3-targeting CAR-T cells for recurrent glioblastoma: a phase 1 trial [0.03%]
针对复发性胶质母细胞瘤的B7-H3靶向CAR-T细胞颅内给药一期临床试验
Yang Zhang,Xiaohan Chi,Rui Feng et al.
Yang Zhang et al.
Recurrent glioblastoma (rGBM) is a leading brain malignancy with few therapeutic options. Here we present the complete results of a phase 1 trial investigating the safety and efficacy of autologous B7-H3-targeting chimeric antigen receptor ...
Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial [0.03%]
氯胺酮联合心理治疗对难治性抑郁症的疗效研究：一项在公共医疗体系开展的随机对照试验
James J Rucker,Tim Mantingh,Jess Kerr-Gaffney et al.
James J Rucker et al.
Psilocybin-assisted therapy may be a promising new treatment for treatment-resistant depression. We examined the feasibility of administering a single 25-mg dose of psilocybin or placebo with psychological support in a randomized controlled...