The TREM2 agonistic antibody AL002 in early Alzheimer's disease: a phase 2 randomized trial [0.03%]
阿尔茨海默病早期患者中 Trem2 激动抗体 AL002 的 2 期随机试验
Catherine J Mummery,Arthur J Mayorga,Adam Simmons et al.
Catherine J Mummery et al.
Triggering receptor expressed on myeloid cells 2 (TREM2) regulates microglial function and is implicated in Alzheimer's disease (AD) pathogenesis. Here we conducted a phase 2, randomized, double-blind, placebo-controlled trial of a humanize...
Hamad Ali,Barrak Alahmad,Abdullah Alibrahim et al.
Hamad Ali et al.
Tiantian Li,Runmei Ma,Qing Wang et al.
Tiantian Li et al.
Long-term efficacy and safety of the single-dose tetravalent Butantan dengue vaccine [0.03%]
Butantan四价登革热单剂疫苗的长期疗效和安全性
Esper G Kallás,José A Moreira,Elizabeth G Patiño et al.
Esper G Kallás et al.
In individuals with prior dengue virus (DENV) exposure, subsequent heterotypic infection can increase the risk of severe disease. A single-dose dengue vaccine that protects against the four DENV serotypes across a wide age range and regardl...
Evaluation of antimicrobial resistance governance across 193 countries to inform the 2026 Global Action Plan update [0.03%]
评估全球193个国家的抗菌素耐药性管理情况以更新2026年全球行动计划
Weiye Chen,Yige Zeng,Jinxin Zheng et al.
Weiye Chen et al.
Antimicrobial resistance (AMR) poses a major global health threat, yet the effectiveness of national action plans (NAPs) remains uncertain. Here we developed a multidimensional One Health governance index through a structured Delphi expert ...
LLM-assisted systematic review of large language models in clinical medicine [0.03%]
基于LLM的临床医学中大型语言模型系统性回顾
Sully F Chen,Anton Alyakin,Andreas Seas et al.
Sully F Chen et al.
Clinical evaluations of large language models (LLMs) have rapidly expanded since 2022, yet their evidence base remains opaque. The overwhelming volume of studies creates challenges for manual curation and review. However, LLMs themselves of...
Dylan P Reichert,Aaron D Levine
Dylan P Reichert
In vivo base editing gene therapy for heterozygous familial hypercholesterolemia: a phase 1 trial [0.03%]
杂合子家族性高胆固醇血症体内碱基编辑基因治疗的I期临床试验
Ping Wan,Siyuan Tang,Dongni Lin et al.
Ping Wan et al.
Heterozygous familial hypercholesterolemia is a common genetic disorder characterized by lifelong elevation of serum low-density lipoprotein cholesterol (LDL-C) and premature atherosclerotic cardiovascular disease. YOLT-101 is an investigat...
Robert S Rosenson,Sascha N Goonewardena
Robert S Rosenson