Petter Brodin
Petter Brodin
Laura Jiménez-Gracia,Davide Maspero,Sergio Aguilar-Fernández et al.
Laura Jiménez-Gracia et al.
Inflammation is a biological phenomenon beneficial for homeostasis, but it is unfavorable if dysregulated. Although major progress has been made in characterizing inflammation in specific diseases, a global, holistic understanding is still ...
Angela L Rasmussen
Angela L Rasmussen
BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial [0.03%]
针对肌萎缩侧索硬化症的BCMA导向型mRNA CAR-T细胞疗法：一项安慰剂对照II期试验的探索性生物标志物分析
Renee R Fedak,Rachel N Ruggerie,Yufei Shan et al.
Renee R Fedak et al.
Chimeric antigen receptor (CAR)-T cell therapies have the potential to transform treatment of autoimmune disease by resetting the immune system. However, adoption of cell therapies in the autoimmune space is limited by hurdles such as inpat...
BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial [0.03%]
针对肌无力的靶向B细胞成熟抗原的CAR-T疗法IIb期随机双盲安慰剂对照临床试验
Tuan Vu,Hacer Durmus,Michael Rivner et al.
Tuan Vu et al.
Myasthenia gravis (MG) is driven by the secretion of autoantibodies from pathogenic B cell maturation antigen (BCMA)-expressing plasma cells. In this phase 2b randomized, controlled, double-blind trial, we evaluated Descartes-08, an autolog...
The NOTCH3 extracellular domain is a serum biomarker for pulmonary arterial hypertension [0.03%]
NOTCH3细胞外区域是肺动脉高压的血清生物标志物
Moises Hernandez,Nolan M Winicki,Cristian D Puerta et al.
Moises Hernandez et al.
New biomarkers are needed to detect and follow individuals with World Health Organization group 1.1 pulmonary hypertension (idiopathic pulmonary arterial hypertension (IPAH)). As NOTCH3 cleavage occurs constitutively in the lungs of individ...
Immune profiling in a living human recipient of a gene-edited pig kidney [0.03%]
活体人类受者移植基因编辑猪肾脏的免疫特征分析
Guilherme T Ribas,André F Cunha,Jonathan P Avila et al.
Guilherme T Ribas et al.
Xenotransplantation of gene-edited pig kidneys offers a promising solution to the shortage of kidneys for organ transplantation. We recently performed a gene-edited pig kidney transplantation into a living human recipient with end-stage kid...
China's evidence-based re-evaluation of traditional Chinese medicine injections [0.03%]
我国中药注射剂的有效性与安全性再评价工作的思考与实践
Chen Chen,Ziwei Hou
Chen Chen
Anti-inflammatory therapy with low-dose IL-2 in acute coronary syndromes: a randomized phase 2 trial [0.03%]
低剂量IL-2抗炎疗法在急性冠脉综合征中的疗效研究：一项随机Ⅱ期临床试验
Rouchelle S Sriranjan-Rothwell,Tian X Zhao,Stephen P Hoole et al.
Rouchelle S Sriranjan-Rothwell et al.
Regulatory T (Treg) cells are powerful endogenous modulators of the immune response and their levels are reduced in patients with acute coronary syndromes (ACSs). Low-dose interleukin-2 (IL-2) has been shown to increase Treg cell levels, po...